| Full name: transient receptor potential cation channel subfamily V member 4 | Alias Symbol: OTRPC4|TRP12|VROAC|VRL-2|VR-OAC|CMT2C | ||
| Type: protein-coding gene | Cytoband: 12q24.11 | ||
| Entrez ID: 59341 | HGNC ID: HGNC:18083 | Ensembl Gene: ENSG00000111199 | OMIM ID: 605427 |
| Drug and gene relationship at DGIdb | |||
TRPV4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of TRPV4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPV4 | 59341 | 219516_at | 0.3385 | 0.3680 | |
| GSE20347 | TRPV4 | 59341 | 219516_at | 0.1270 | 0.2252 | |
| GSE23400 | TRPV4 | 59341 | 219516_at | -0.1196 | 0.0334 | |
| GSE26886 | TRPV4 | 59341 | 219516_at | -0.1692 | 0.2028 | |
| GSE29001 | TRPV4 | 59341 | 219516_at | -0.0297 | 0.8387 | |
| GSE38129 | TRPV4 | 59341 | 219516_at | 0.1434 | 0.3106 | |
| GSE45670 | TRPV4 | 59341 | 219516_at | 0.2047 | 0.0943 | |
| GSE53622 | TRPV4 | 59341 | 127058 | 0.7905 | 0.0000 | |
| GSE53624 | TRPV4 | 59341 | 127058 | 0.4636 | 0.0000 | |
| GSE63941 | TRPV4 | 59341 | 219516_at | 0.3455 | 0.4786 | |
| GSE77861 | TRPV4 | 59341 | 219516_at | 0.1583 | 0.4905 | |
| GSE97050 | TRPV4 | 59341 | A_24_P13381 | 0.4887 | 0.1298 | |
| SRP007169 | TRPV4 | 59341 | RNAseq | 0.9948 | 0.0764 | |
| SRP064894 | TRPV4 | 59341 | RNAseq | -0.0345 | 0.9184 | |
| SRP133303 | TRPV4 | 59341 | RNAseq | -0.0360 | 0.9313 | |
| SRP159526 | TRPV4 | 59341 | RNAseq | 0.4988 | 0.1804 | |
| SRP193095 | TRPV4 | 59341 | RNAseq | 0.1553 | 0.6544 | |
| SRP219564 | TRPV4 | 59341 | RNAseq | -0.1909 | 0.8103 | |
| TCGA | TRPV4 | 59341 | RNAseq | 1.0890 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TRPV4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRPV4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPV4 | 59341 | 5 | 3 | 22 | |
| GSE20123 | TRPV4 | 59341 | 5 | 3 | 22 | |
| GSE43470 | TRPV4 | 59341 | 2 | 1 | 40 | |
| GSE46452 | TRPV4 | 59341 | 9 | 1 | 49 | |
| GSE47630 | TRPV4 | 59341 | 9 | 1 | 30 | |
| GSE54993 | TRPV4 | 59341 | 0 | 5 | 65 | |
| GSE54994 | TRPV4 | 59341 | 4 | 3 | 46 | |
| GSE60625 | TRPV4 | 59341 | 0 | 0 | 11 | |
| GSE74703 | TRPV4 | 59341 | 2 | 0 | 34 | |
| GSE74704 | TRPV4 | 59341 | 2 | 2 | 16 | |
| TCGA | TRPV4 | 59341 | 22 | 10 | 64 |
Total number of gains: 60; Total number of losses: 29; Total Number of normals: 399.
Somatic mutations of TRPV4:
Generating mutation plots.
Highly correlated genes for TRPV4:
Showing top 20/130 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPV4 | BRIP1 | 0.764485 | 3 | 0 | 3 |
| TRPV4 | BLM | 0.662952 | 3 | 0 | 3 |
| TRPV4 | CDCA3 | 0.659943 | 3 | 0 | 3 |
| TRPV4 | CORO1B | 0.659909 | 3 | 0 | 3 |
| TRPV4 | MND1 | 0.646456 | 3 | 0 | 3 |
| TRPV4 | SPAG5 | 0.639632 | 3 | 0 | 3 |
| TRPV4 | SCD | 0.630298 | 3 | 0 | 3 |
| TRPV4 | GRHL2 | 0.625976 | 4 | 0 | 4 |
| TRPV4 | FKBP1A | 0.624691 | 3 | 0 | 3 |
| TRPV4 | GEN1 | 0.612576 | 3 | 0 | 3 |
| TRPV4 | PRR13 | 0.612245 | 3 | 0 | 3 |
| TRPV4 | PLK1 | 0.604672 | 4 | 0 | 3 |
| TRPV4 | BUB1 | 0.6043 | 4 | 0 | 3 |
| TRPV4 | WDR62 | 0.603295 | 4 | 0 | 3 |
| TRPV4 | DSC3 | 0.602261 | 5 | 0 | 4 |
| TRPV4 | SQLE | 0.601523 | 4 | 0 | 3 |
| TRPV4 | TLCD1 | 0.597534 | 4 | 0 | 3 |
| TRPV4 | ESCO2 | 0.597489 | 4 | 0 | 3 |
| TRPV4 | UHRF1 | 0.59324 | 3 | 0 | 3 |
| TRPV4 | PCNA | 0.591848 | 4 | 0 | 3 |
For details and further investigation, click here
