| Full name: FKBP prolyl isomerase 5 | Alias Symbol: FKBP51|FKBP54|PPIase|P54|Ptg-10 | ||
| Type: protein-coding gene | Cytoband: 6p21.31 | ||
| Entrez ID: 2289 | HGNC ID: HGNC:3721 | Ensembl Gene: ENSG00000096060 | OMIM ID: 602623 |
| Drug and gene relationship at DGIdb | |||
Expression of FKBP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FKBP5 | 2289 | 224840_at | -0.5373 | 0.5497 | |
| GSE20347 | FKBP5 | 2289 | 204560_at | -0.1683 | 0.1088 | |
| GSE23400 | FKBP5 | 2289 | 204560_at | -0.0350 | 0.6999 | |
| GSE26886 | FKBP5 | 2289 | 224840_at | 0.9077 | 0.0162 | |
| GSE29001 | FKBP5 | 2289 | 204560_at | 0.1077 | 0.7471 | |
| GSE38129 | FKBP5 | 2289 | 204560_at | -0.3025 | 0.0786 | |
| GSE45670 | FKBP5 | 2289 | 224840_at | -1.1655 | 0.0011 | |
| GSE53622 | FKBP5 | 2289 | 10221 | -0.5367 | 0.0000 | |
| GSE53624 | FKBP5 | 2289 | 10221 | -0.2595 | 0.0415 | |
| GSE63941 | FKBP5 | 2289 | 224840_at | 0.8356 | 0.3591 | |
| GSE77861 | FKBP5 | 2289 | 224840_at | 0.1186 | 0.8285 | |
| GSE97050 | FKBP5 | 2289 | A_24_P38081 | -0.6287 | 0.2582 | |
| SRP007169 | FKBP5 | 2289 | RNAseq | 0.2532 | 0.5023 | |
| SRP008496 | FKBP5 | 2289 | RNAseq | 0.5403 | 0.0243 | |
| SRP064894 | FKBP5 | 2289 | RNAseq | -0.2301 | 0.6076 | |
| SRP133303 | FKBP5 | 2289 | RNAseq | -0.1816 | 0.7276 | |
| SRP159526 | FKBP5 | 2289 | RNAseq | -0.7489 | 0.2266 | |
| SRP193095 | FKBP5 | 2289 | RNAseq | -0.0614 | 0.7396 | |
| SRP219564 | FKBP5 | 2289 | RNAseq | -0.0388 | 0.9341 | |
| TCGA | FKBP5 | 2289 | RNAseq | -0.4749 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FKBP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FKBP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FKBP5 | 2289 | 5 | 0 | 25 | |
| GSE20123 | FKBP5 | 2289 | 5 | 0 | 25 | |
| GSE43470 | FKBP5 | 2289 | 5 | 1 | 37 | |
| GSE46452 | FKBP5 | 2289 | 2 | 9 | 48 | |
| GSE47630 | FKBP5 | 2289 | 8 | 4 | 28 | |
| GSE54993 | FKBP5 | 2289 | 3 | 1 | 66 | |
| GSE54994 | FKBP5 | 2289 | 11 | 4 | 38 | |
| GSE60625 | FKBP5 | 2289 | 1 | 0 | 10 | |
| GSE74703 | FKBP5 | 2289 | 5 | 0 | 31 | |
| GSE74704 | FKBP5 | 2289 | 2 | 0 | 18 | |
| TCGA | FKBP5 | 2289 | 15 | 15 | 66 |
Total number of gains: 62; Total number of losses: 34; Total Number of normals: 392.
Somatic mutations of FKBP5:
Generating mutation plots.
Highly correlated genes for FKBP5:
Showing top 20/322 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FKBP5 | RBPJ | 0.751155 | 3 | 0 | 3 |
| FKBP5 | MTPAP | 0.751111 | 3 | 0 | 3 |
| FKBP5 | GNG2 | 0.746366 | 3 | 0 | 3 |
| FKBP5 | DIAPH2 | 0.738785 | 3 | 0 | 3 |
| FKBP5 | KLHDC8B | 0.732922 | 3 | 0 | 3 |
| FKBP5 | SLC43A2 | 0.693129 | 3 | 0 | 3 |
| FKBP5 | GSK3A | 0.689183 | 3 | 0 | 3 |
| FKBP5 | GFRA1 | 0.685528 | 3 | 0 | 3 |
| FKBP5 | FIBIN | 0.681473 | 3 | 0 | 3 |
| FKBP5 | LRCH3 | 0.678651 | 3 | 0 | 3 |
| FKBP5 | RPL23A | 0.676109 | 3 | 0 | 3 |
| FKBP5 | CHN2 | 0.675263 | 3 | 0 | 3 |
| FKBP5 | BMPR2 | 0.674957 | 4 | 0 | 3 |
| FKBP5 | SVEP1 | 0.670703 | 4 | 0 | 3 |
| FKBP5 | RTN1 | 0.670312 | 4 | 0 | 3 |
| FKBP5 | HSD11B1 | 0.668231 | 4 | 0 | 4 |
| FKBP5 | GMPR | 0.662284 | 3 | 0 | 3 |
| FKBP5 | UBXN10 | 0.651617 | 3 | 0 | 3 |
| FKBP5 | DEXI | 0.650359 | 4 | 0 | 4 |
| FKBP5 | PTPN4 | 0.650149 | 3 | 0 | 3 |
For details and further investigation, click here
