| Full name: dysferlin | Alias Symbol: FER1L1 | ||
| Type: protein-coding gene | Cytoband: 2p13.2 | ||
| Entrez ID: 8291 | HGNC ID: HGNC:3097 | Ensembl Gene: ENSG00000135636 | OMIM ID: 603009 |
| Drug and gene relationship at DGIdb | |||
Expression of DYSF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DYSF | 8291 | 218660_at | -0.2026 | 0.7262 | |
| GSE20347 | DYSF | 8291 | 218660_at | 0.0182 | 0.8962 | |
| GSE23400 | DYSF | 8291 | 218660_at | -0.1578 | 0.0130 | |
| GSE26886 | DYSF | 8291 | 218660_at | 0.3050 | 0.1683 | |
| GSE29001 | DYSF | 8291 | 218660_at | 0.0048 | 0.9836 | |
| GSE38129 | DYSF | 8291 | 218660_at | -0.3794 | 0.0387 | |
| GSE45670 | DYSF | 8291 | 218660_at | -0.0101 | 0.9639 | |
| GSE53622 | DYSF | 8291 | 57760 | -0.0641 | 0.7093 | |
| GSE53624 | DYSF | 8291 | 57760 | 0.0416 | 0.7492 | |
| GSE63941 | DYSF | 8291 | 218660_at | 0.1824 | 0.4025 | |
| GSE77861 | DYSF | 8291 | 218660_at | 0.0503 | 0.7953 | |
| GSE97050 | DYSF | 8291 | A_23_P39931 | -0.4784 | 0.1453 | |
| SRP007169 | DYSF | 8291 | RNAseq | 3.1224 | 0.0000 | |
| SRP008496 | DYSF | 8291 | RNAseq | 3.3714 | 0.0000 | |
| SRP064894 | DYSF | 8291 | RNAseq | 0.7217 | 0.0211 | |
| SRP133303 | DYSF | 8291 | RNAseq | 0.0851 | 0.7855 | |
| SRP159526 | DYSF | 8291 | RNAseq | 0.0518 | 0.8833 | |
| SRP193095 | DYSF | 8291 | RNAseq | 1.7114 | 0.0000 | |
| SRP219564 | DYSF | 8291 | RNAseq | -0.2803 | 0.7040 | |
| TCGA | DYSF | 8291 | RNAseq | -0.2021 | 0.0863 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DYSF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DYSF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DYSF | 8291 | 11 | 1 | 18 | |
| GSE20123 | DYSF | 8291 | 11 | 1 | 18 | |
| GSE43470 | DYSF | 8291 | 3 | 0 | 40 | |
| GSE46452 | DYSF | 8291 | 2 | 3 | 54 | |
| GSE47630 | DYSF | 8291 | 7 | 0 | 33 | |
| GSE54993 | DYSF | 8291 | 0 | 6 | 64 | |
| GSE54994 | DYSF | 8291 | 11 | 0 | 42 | |
| GSE60625 | DYSF | 8291 | 0 | 3 | 8 | |
| GSE74703 | DYSF | 8291 | 3 | 0 | 33 | |
| GSE74704 | DYSF | 8291 | 9 | 0 | 11 | |
| TCGA | DYSF | 8291 | 37 | 2 | 57 |
Total number of gains: 94; Total number of losses: 16; Total Number of normals: 378.
Somatic mutations of DYSF:
Generating mutation plots.
Highly correlated genes for DYSF:
Showing top 20/560 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DYSF | SMARCD3 | 0.717144 | 5 | 0 | 5 |
| DYSF | ACTC1 | 0.700629 | 4 | 0 | 4 |
| DYSF | LAMB2 | 0.691087 | 7 | 0 | 7 |
| DYSF | GIPC3 | 0.683363 | 4 | 0 | 4 |
| DYSF | PEG3 | 0.660644 | 3 | 0 | 3 |
| DYSF | RHOQ | 0.650285 | 5 | 0 | 4 |
| DYSF | ILK | 0.64495 | 10 | 0 | 8 |
| DYSF | DEXI | 0.644776 | 4 | 0 | 3 |
| DYSF | DENND2A | 0.644311 | 8 | 0 | 6 |
| DYSF | ROBO4 | 0.642843 | 5 | 0 | 4 |
| DYSF | PARVA | 0.642335 | 6 | 0 | 6 |
| DYSF | GNAZ | 0.63927 | 4 | 0 | 4 |
| DYSF | PLP1 | 0.635783 | 6 | 0 | 4 |
| DYSF | SSC5D | 0.634728 | 3 | 0 | 3 |
| DYSF | CCL23 | 0.634704 | 3 | 0 | 3 |
| DYSF | GLIPR2 | 0.634637 | 6 | 0 | 5 |
| DYSF | FOS | 0.634607 | 3 | 0 | 3 |
| DYSF | TGFB1I1 | 0.634405 | 10 | 0 | 9 |
| DYSF | PCDH9 | 0.633784 | 5 | 0 | 4 |
| DYSF | C1orf54 | 0.630372 | 6 | 0 | 6 |
For details and further investigation, click here
