| Full name: immediate early response 2 | Alias Symbol: ETR101 | ||
| Type: protein-coding gene | Cytoband: 19p13.13 | ||
| Entrez ID: 9592 | HGNC ID: HGNC:28871 | Ensembl Gene: ENSG00000160888 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of IER2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IER2 | 9592 | 202081_at | -0.7874 | 0.3318 | |
| GSE20347 | IER2 | 9592 | 202081_at | -0.2780 | 0.1805 | |
| GSE23400 | IER2 | 9592 | 202081_at | -0.2435 | 0.0138 | |
| GSE26886 | IER2 | 9592 | 202081_at | -0.4396 | 0.0395 | |
| GSE29001 | IER2 | 9592 | 202081_at | -0.2312 | 0.5839 | |
| GSE38129 | IER2 | 9592 | 202081_at | -0.3490 | 0.0632 | |
| GSE45670 | IER2 | 9592 | 202081_at | 0.0214 | 0.9321 | |
| GSE63941 | IER2 | 9592 | 202081_at | 0.9324 | 0.2006 | |
| GSE77861 | IER2 | 9592 | 202081_at | 0.2778 | 0.3601 | |
| GSE97050 | IER2 | 9592 | A_32_P36235 | -0.4609 | 0.4587 | |
| SRP007169 | IER2 | 9592 | RNAseq | -0.6886 | 0.1013 | |
| SRP008496 | IER2 | 9592 | RNAseq | -0.5754 | 0.0205 | |
| SRP064894 | IER2 | 9592 | RNAseq | 0.3226 | 0.3881 | |
| SRP133303 | IER2 | 9592 | RNAseq | -0.4223 | 0.1274 | |
| SRP159526 | IER2 | 9592 | RNAseq | 0.0973 | 0.7526 | |
| SRP193095 | IER2 | 9592 | RNAseq | 0.0050 | 0.9797 | |
| SRP219564 | IER2 | 9592 | RNAseq | -0.2619 | 0.5495 | |
| TCGA | IER2 | 9592 | RNAseq | 0.0445 | 0.5161 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IER2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of IER2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IER2 | 9592 | 4 | 2 | 24 | |
| GSE20123 | IER2 | 9592 | 3 | 1 | 26 | |
| GSE43470 | IER2 | 9592 | 2 | 6 | 35 | |
| GSE46452 | IER2 | 9592 | 47 | 1 | 11 | |
| GSE47630 | IER2 | 9592 | 4 | 7 | 29 | |
| GSE54993 | IER2 | 9592 | 16 | 3 | 51 | |
| GSE54994 | IER2 | 9592 | 6 | 13 | 34 | |
| GSE60625 | IER2 | 9592 | 9 | 0 | 2 | |
| GSE74703 | IER2 | 9592 | 2 | 4 | 30 | |
| GSE74704 | IER2 | 9592 | 0 | 1 | 19 | |
| TCGA | IER2 | 9592 | 18 | 13 | 65 |
Total number of gains: 111; Total number of losses: 51; Total Number of normals: 326.
Somatic mutations of IER2:
Generating mutation plots.
Highly correlated genes for IER2:
Showing top 20/85 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IER2 | JUNB | 0.745859 | 11 | 0 | 10 |
| IER2 | PLP1 | 0.727632 | 3 | 0 | 3 |
| IER2 | SLC25A25 | 0.713564 | 4 | 0 | 3 |
| IER2 | C3orf18 | 0.71043 | 3 | 0 | 3 |
| IER2 | HSPB7 | 0.692096 | 3 | 0 | 3 |
| IER2 | HAND2 | 0.688197 | 3 | 0 | 3 |
| IER2 | SGCA | 0.687156 | 3 | 0 | 3 |
| IER2 | NR4A2 | 0.674884 | 7 | 0 | 6 |
| IER2 | SIK1 | 0.666913 | 4 | 0 | 3 |
| IER2 | DGKB | 0.660784 | 3 | 0 | 3 |
| IER2 | RAB6B | 0.660237 | 3 | 0 | 3 |
| IER2 | CADM3 | 0.656619 | 3 | 0 | 3 |
| IER2 | ZNF385D | 0.649016 | 4 | 0 | 3 |
| IER2 | MCL1 | 0.648794 | 7 | 0 | 7 |
| IER2 | GPR135 | 0.639584 | 3 | 0 | 3 |
| IER2 | CASQ2 | 0.638827 | 3 | 0 | 3 |
| IER2 | MAP3K8 | 0.636807 | 3 | 0 | 3 |
| IER2 | HAS1 | 0.634156 | 4 | 0 | 3 |
| IER2 | KLF1 | 0.633311 | 3 | 0 | 3 |
| IER2 | EPHA6 | 0.632989 | 5 | 0 | 4 |
For details and further investigation, click here
