| Full name: grancalcin | Alias Symbol: GCL | ||
| Type: protein-coding gene | Cytoband: 2q24.2 | ||
| Entrez ID: 25801 | HGNC ID: HGNC:15990 | Ensembl Gene: ENSG00000115271 | OMIM ID: 607030 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GCA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GCA | 25801 | 203765_at | 1.2531 | 0.0248 | |
| GSE20347 | GCA | 25801 | 203765_at | -0.0719 | 0.7643 | |
| GSE23400 | GCA | 25801 | 203765_at | 0.2096 | 0.0245 | |
| GSE26886 | GCA | 25801 | 203765_at | -0.5067 | 0.2354 | |
| GSE29001 | GCA | 25801 | 203765_at | 0.2335 | 0.5768 | |
| GSE38129 | GCA | 25801 | 203765_at | 0.0076 | 0.9776 | |
| GSE45670 | GCA | 25801 | 203765_at | -0.0391 | 0.8996 | |
| GSE53622 | GCA | 25801 | 10279 | 0.0074 | 0.9422 | |
| GSE53624 | GCA | 25801 | 10279 | -0.0659 | 0.3763 | |
| GSE63941 | GCA | 25801 | 203765_at | 0.4045 | 0.7466 | |
| GSE77861 | GCA | 25801 | 203765_at | -0.4013 | 0.2314 | |
| GSE97050 | GCA | 25801 | A_23_P28485 | 0.1520 | 0.5123 | |
| SRP007169 | GCA | 25801 | RNAseq | 0.2412 | 0.5964 | |
| SRP008496 | GCA | 25801 | RNAseq | 0.1588 | 0.6183 | |
| SRP064894 | GCA | 25801 | RNAseq | 0.1841 | 0.3996 | |
| SRP133303 | GCA | 25801 | RNAseq | 0.4591 | 0.0612 | |
| SRP159526 | GCA | 25801 | RNAseq | -0.0965 | 0.7171 | |
| SRP193095 | GCA | 25801 | RNAseq | 0.0451 | 0.8052 | |
| SRP219564 | GCA | 25801 | RNAseq | 0.0672 | 0.8675 | |
| TCGA | GCA | 25801 | RNAseq | -0.2978 | 0.0027 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GCA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GCA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GCA | 25801 | 4 | 1 | 25 | |
| GSE20123 | GCA | 25801 | 4 | 1 | 25 | |
| GSE43470 | GCA | 25801 | 4 | 1 | 38 | |
| GSE46452 | GCA | 25801 | 1 | 4 | 54 | |
| GSE47630 | GCA | 25801 | 5 | 3 | 32 | |
| GSE54993 | GCA | 25801 | 0 | 5 | 65 | |
| GSE54994 | GCA | 25801 | 11 | 2 | 40 | |
| GSE60625 | GCA | 25801 | 0 | 3 | 8 | |
| GSE74703 | GCA | 25801 | 3 | 1 | 32 | |
| GSE74704 | GCA | 25801 | 3 | 0 | 17 | |
| TCGA | GCA | 25801 | 23 | 10 | 63 |
Total number of gains: 58; Total number of losses: 31; Total Number of normals: 399.
Somatic mutations of GCA:
Generating mutation plots.
Highly correlated genes for GCA:
Showing all 20 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GCA | POLQ | 0.685584 | 3 | 0 | 3 |
| GCA | DGAT2 | 0.66454 | 3 | 0 | 3 |
| GCA | APBA2 | 0.6585 | 3 | 0 | 3 |
| GCA | TIGD2 | 0.631317 | 3 | 0 | 3 |
| GCA | OGFR | 0.598156 | 3 | 0 | 3 |
| GCA | GNLY | 0.567375 | 4 | 0 | 3 |
| GCA | CEP135 | 0.567108 | 7 | 0 | 4 |
| GCA | RNF41 | 0.557364 | 3 | 0 | 3 |
| GCA | RANBP2 | 0.557127 | 5 | 0 | 4 |
| GCA | MOB1B | 0.553019 | 4 | 0 | 3 |
| GCA | ARID4B | 0.536605 | 4 | 0 | 3 |
| GCA | DCUN1D1 | 0.535622 | 6 | 0 | 4 |
| GCA | SUDS3 | 0.535492 | 4 | 0 | 3 |
| GCA | FCGR1B | 0.52816 | 5 | 0 | 3 |
| GCA | PLCL2 | 0.52099 | 7 | 0 | 4 |
| GCA | CYFIP2 | 0.519307 | 7 | 0 | 4 |
| GCA | CLDN23 | 0.511688 | 4 | 0 | 3 |
| GCA | CXorf38 | 0.508662 | 5 | 0 | 3 |
| GCA | PSMB9 | 0.507449 | 8 | 0 | 4 |
| GCA | ARFGEF1 | 0.507235 | 4 | 0 | 3 |
For details and further investigation, click here
