| Full name: growth factor independent 1 transcriptional repressor | Alias Symbol: GFI1A|GFI-1 | ||
| Type: protein-coding gene | Cytoband: 1p22.1 | ||
| Entrez ID: 2672 | HGNC ID: HGNC:4237 | Ensembl Gene: ENSG00000162676 | OMIM ID: 600871 |
| Drug and gene relationship at DGIdb | |||
Expression of GFI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GFI1 | 2672 | 206589_at | 0.2670 | 0.3685 | |
| GSE20347 | GFI1 | 2672 | 206589_at | 0.1008 | 0.2297 | |
| GSE23400 | GFI1 | 2672 | 206589_at | 0.0358 | 0.4575 | |
| GSE26886 | GFI1 | 2672 | 206589_at | 0.2152 | 0.3788 | |
| GSE29001 | GFI1 | 2672 | 206589_at | 0.1413 | 0.5905 | |
| GSE38129 | GFI1 | 2672 | 206589_at | 0.1011 | 0.3101 | |
| GSE45670 | GFI1 | 2672 | 206589_at | 0.1730 | 0.2800 | |
| GSE63941 | GFI1 | 2672 | 206589_at | 0.4656 | 0.1988 | |
| GSE77861 | GFI1 | 2672 | 206589_at | 0.0093 | 0.9255 | |
| GSE97050 | GFI1 | 2672 | A_23_P257365 | 0.5699 | 0.2104 | |
| SRP064894 | GFI1 | 2672 | RNAseq | 0.5453 | 0.0534 | |
| SRP133303 | GFI1 | 2672 | RNAseq | 0.0441 | 0.9096 | |
| SRP159526 | GFI1 | 2672 | RNAseq | -0.2583 | 0.6984 | |
| SRP193095 | GFI1 | 2672 | RNAseq | 0.0596 | 0.8311 | |
| SRP219564 | GFI1 | 2672 | RNAseq | 1.0728 | 0.0143 | |
| TCGA | GFI1 | 2672 | RNAseq | 0.6801 | 0.0062 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GFI1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GFI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GFI1 | 2672 | 0 | 8 | 22 | |
| GSE20123 | GFI1 | 2672 | 0 | 8 | 22 | |
| GSE43470 | GFI1 | 2672 | 2 | 6 | 35 | |
| GSE46452 | GFI1 | 2672 | 1 | 1 | 57 | |
| GSE47630 | GFI1 | 2672 | 8 | 5 | 27 | |
| GSE54993 | GFI1 | 2672 | 0 | 1 | 69 | |
| GSE54994 | GFI1 | 2672 | 6 | 3 | 44 | |
| GSE60625 | GFI1 | 2672 | 0 | 0 | 11 | |
| GSE74703 | GFI1 | 2672 | 1 | 5 | 30 | |
| GSE74704 | GFI1 | 2672 | 0 | 5 | 15 | |
| TCGA | GFI1 | 2672 | 6 | 24 | 66 |
Total number of gains: 24; Total number of losses: 66; Total Number of normals: 398.
Somatic mutations of GFI1:
Generating mutation plots.
Highly correlated genes for GFI1:
Showing top 20/89 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GFI1 | TNIP2 | 0.689313 | 3 | 0 | 3 |
| GFI1 | TAF1D | 0.687003 | 3 | 0 | 3 |
| GFI1 | WDR66 | 0.683638 | 3 | 0 | 3 |
| GFI1 | ZNF713 | 0.650169 | 3 | 0 | 3 |
| GFI1 | IFNGR1 | 0.636982 | 3 | 0 | 3 |
| GFI1 | CENPE | 0.630798 | 3 | 0 | 3 |
| GFI1 | PDE7A | 0.625192 | 4 | 0 | 3 |
| GFI1 | SLBP | 0.623215 | 4 | 0 | 4 |
| GFI1 | HLA-F | 0.620981 | 4 | 0 | 3 |
| GFI1 | TSKU | 0.620969 | 3 | 0 | 3 |
| GFI1 | LYPD1 | 0.620106 | 4 | 0 | 3 |
| GFI1 | BRIX1 | 0.619625 | 3 | 0 | 3 |
| GFI1 | SIPA1L3 | 0.618861 | 4 | 0 | 3 |
| GFI1 | SH3BP2 | 0.616955 | 4 | 0 | 3 |
| GFI1 | GCNT1 | 0.612943 | 3 | 0 | 3 |
| GFI1 | AIM2 | 0.606885 | 6 | 0 | 4 |
| GFI1 | GEN1 | 0.603199 | 3 | 0 | 3 |
| GFI1 | CKAP2 | 0.602264 | 4 | 0 | 3 |
| GFI1 | CCNE2 | 0.597801 | 5 | 0 | 3 |
| GFI1 | LY96 | 0.597603 | 4 | 0 | 3 |
For details and further investigation, click here
