| Full name: G protein subunit alpha transducin 3 | Alias Symbol: gustducin|GDCA | ||
| Type: protein-coding gene | Cytoband: 7q21.11 | ||
| Entrez ID: 346562 | HGNC ID: HGNC:22800 | Ensembl Gene: ENSG00000214415 | OMIM ID: 139395 |
| Drug and gene relationship at DGIdb | |||
GNAT3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04742 | Taste transduction | |
| hsa04973 | Carbohydrate digestion and absorption |
Expression of GNAT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GNAT3 | 346562 | 216590_at | -0.0846 | 0.7652 | |
| GSE20347 | GNAT3 | 346562 | 216590_at | -0.0012 | 0.9885 | |
| GSE23400 | GNAT3 | 346562 | 216590_at | -0.0527 | 0.1034 | |
| GSE26886 | GNAT3 | 346562 | 216590_at | 0.0101 | 0.9222 | |
| GSE29001 | GNAT3 | 346562 | 216590_at | -0.1315 | 0.3159 | |
| GSE38129 | GNAT3 | 346562 | 216590_at | 0.0000 | 0.9994 | |
| GSE45670 | GNAT3 | 346562 | 216590_at | 0.0323 | 0.6664 | |
| GSE53622 | GNAT3 | 346562 | 30089 | -0.0882 | 0.6469 | |
| GSE53624 | GNAT3 | 346562 | 30089 | 0.0827 | 0.4278 | |
| GSE63941 | GNAT3 | 346562 | 216590_at | -0.1012 | 0.3336 | |
| GSE77861 | GNAT3 | 346562 | 216590_at | -0.0541 | 0.6220 | |
| TCGA | GNAT3 | 346562 | RNAseq | 0.3991 | 0.8494 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GNAT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GNAT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GNAT3 | 346562 | 13 | 1 | 16 | |
| GSE20123 | GNAT3 | 346562 | 12 | 1 | 17 | |
| GSE43470 | GNAT3 | 346562 | 4 | 1 | 38 | |
| GSE46452 | GNAT3 | 346562 | 11 | 0 | 48 | |
| GSE47630 | GNAT3 | 346562 | 7 | 3 | 30 | |
| GSE54993 | GNAT3 | 346562 | 1 | 7 | 62 | |
| GSE54994 | GNAT3 | 346562 | 16 | 3 | 34 | |
| GSE60625 | GNAT3 | 346562 | 0 | 0 | 11 | |
| GSE74703 | GNAT3 | 346562 | 3 | 1 | 32 | |
| GSE74704 | GNAT3 | 346562 | 8 | 1 | 11 | |
| TCGA | GNAT3 | 346562 | 46 | 5 | 45 |
Total number of gains: 121; Total number of losses: 23; Total Number of normals: 344.
Somatic mutations of GNAT3:
Generating mutation plots.
Highly correlated genes for GNAT3:
Showing top 20/317 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GNAT3 | CTNNA2 | 0.671789 | 3 | 0 | 3 |
| GNAT3 | RUNX1T1 | 0.661881 | 3 | 0 | 3 |
| GNAT3 | SLC13A3 | 0.649011 | 4 | 0 | 3 |
| GNAT3 | KRTAP5-8 | 0.636342 | 5 | 0 | 5 |
| GNAT3 | NEUROD1 | 0.63547 | 3 | 0 | 3 |
| GNAT3 | NR0B2 | 0.634674 | 3 | 0 | 3 |
| GNAT3 | RUNX2 | 0.627887 | 5 | 0 | 4 |
| GNAT3 | CGA | 0.626213 | 3 | 0 | 3 |
| GNAT3 | OR6A2 | 0.621915 | 4 | 0 | 4 |
| GNAT3 | SGK2 | 0.620576 | 5 | 0 | 5 |
| GNAT3 | KCNC3 | 0.62005 | 5 | 0 | 4 |
| GNAT3 | FOXN3-AS2 | 0.61957 | 4 | 0 | 3 |
| GNAT3 | WDR63 | 0.612962 | 3 | 0 | 3 |
| GNAT3 | SV2C | 0.612087 | 4 | 0 | 3 |
| GNAT3 | FGF4 | 0.608176 | 3 | 0 | 3 |
| GNAT3 | KLK14 | 0.607735 | 4 | 0 | 4 |
| GNAT3 | FAM110D | 0.606787 | 3 | 0 | 3 |
| GNAT3 | GNRHR | 0.604945 | 5 | 0 | 5 |
| GNAT3 | NPHS2 | 0.602876 | 5 | 0 | 5 |
| GNAT3 | MS4A1 | 0.600107 | 3 | 0 | 3 |
For details and further investigation, click here
