| Full name: RAB5C, member RAS oncogene family | Alias Symbol: RAB5CL | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 5878 | HGNC ID: HGNC:9785 | Ensembl Gene: ENSG00000108774 | OMIM ID: 604037 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RAB5C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa05152 | Tuberculosis |
Expression of RAB5C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAB5C | 5878 | 201140_s_at | 0.2413 | 0.3950 | |
| GSE20347 | RAB5C | 5878 | 201140_s_at | 0.0210 | 0.8765 | |
| GSE23400 | RAB5C | 5878 | 201140_s_at | 0.0722 | 0.2523 | |
| GSE26886 | RAB5C | 5878 | 201140_s_at | -0.2793 | 0.0675 | |
| GSE29001 | RAB5C | 5878 | 201156_s_at | -0.0735 | 0.6318 | |
| GSE38129 | RAB5C | 5878 | 201140_s_at | 0.0655 | 0.6828 | |
| GSE45670 | RAB5C | 5878 | 201156_s_at | 0.2398 | 0.0849 | |
| GSE53622 | RAB5C | 5878 | 142083 | 0.2460 | 0.0000 | |
| GSE53624 | RAB5C | 5878 | 142083 | 0.3169 | 0.0000 | |
| GSE63941 | RAB5C | 5878 | 201156_s_at | 1.3040 | 0.0005 | |
| GSE77861 | RAB5C | 5878 | 201140_s_at | 0.1748 | 0.2276 | |
| GSE97050 | RAB5C | 5878 | A_23_P107211 | 0.7536 | 0.0620 | |
| SRP007169 | RAB5C | 5878 | RNAseq | -0.3583 | 0.3677 | |
| SRP008496 | RAB5C | 5878 | RNAseq | -0.4482 | 0.0439 | |
| SRP064894 | RAB5C | 5878 | RNAseq | 0.2777 | 0.0123 | |
| SRP133303 | RAB5C | 5878 | RNAseq | 0.2976 | 0.0116 | |
| SRP159526 | RAB5C | 5878 | RNAseq | -0.0212 | 0.9375 | |
| SRP193095 | RAB5C | 5878 | RNAseq | -0.0215 | 0.8791 | |
| SRP219564 | RAB5C | 5878 | RNAseq | 0.0954 | 0.7986 | |
| TCGA | RAB5C | 5878 | RNAseq | -0.0239 | 0.5665 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by RAB5C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAB5C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAB5C | 5878 | 6 | 2 | 22 | |
| GSE20123 | RAB5C | 5878 | 6 | 2 | 22 | |
| GSE43470 | RAB5C | 5878 | 1 | 2 | 40 | |
| GSE46452 | RAB5C | 5878 | 34 | 0 | 25 | |
| GSE47630 | RAB5C | 5878 | 8 | 1 | 31 | |
| GSE54993 | RAB5C | 5878 | 3 | 4 | 63 | |
| GSE54994 | RAB5C | 5878 | 8 | 5 | 40 | |
| GSE60625 | RAB5C | 5878 | 4 | 0 | 7 | |
| GSE74703 | RAB5C | 5878 | 1 | 1 | 34 | |
| GSE74704 | RAB5C | 5878 | 4 | 1 | 15 | |
| TCGA | RAB5C | 5878 | 23 | 6 | 67 |
Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.
Somatic mutations of RAB5C:
Generating mutation plots.
Highly correlated genes for RAB5C:
Showing top 20/152 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAB5C | CDC6 | 0.684989 | 3 | 0 | 3 |
| RAB5C | MRPL38 | 0.677441 | 3 | 0 | 3 |
| RAB5C | HNRNPC | 0.656621 | 3 | 0 | 3 |
| RAB5C | GHDC | 0.651229 | 3 | 0 | 3 |
| RAB5C | GTF2I | 0.638979 | 3 | 0 | 3 |
| RAB5C | SLC25A39 | 0.634969 | 4 | 0 | 3 |
| RAB5C | LGALS3BP | 0.626576 | 5 | 0 | 5 |
| RAB5C | PTGES2 | 0.618654 | 5 | 0 | 4 |
| RAB5C | HMGA2 | 0.611088 | 3 | 0 | 3 |
| RAB5C | GAPDH | 0.606431 | 5 | 0 | 3 |
| RAB5C | ASCC1 | 0.605288 | 6 | 0 | 5 |
| RAB5C | TUBA1C | 0.602786 | 5 | 0 | 4 |
| RAB5C | PPP4C | 0.601469 | 5 | 0 | 4 |
| RAB5C | SEZ6L2 | 0.600084 | 3 | 0 | 3 |
| RAB5C | NOMO1 | 0.599262 | 3 | 0 | 3 |
| RAB5C | PRELID1 | 0.595997 | 4 | 0 | 3 |
| RAB5C | NDUFB2 | 0.590078 | 3 | 0 | 3 |
| RAB5C | M6PR | 0.588432 | 6 | 0 | 4 |
| RAB5C | LSM12 | 0.588431 | 9 | 0 | 7 |
| RAB5C | EXOC3L2 | 0.588072 | 3 | 0 | 3 |
For details and further investigation, click here
