| Full name: receptor activity modifying protein 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 10267 | HGNC ID: HGNC:9843 | Ensembl Gene: ENSG00000132329 | OMIM ID: 605153 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RAMP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04270 | Vascular smooth muscle contraction |
Expression of RAMP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAMP1 | 10267 | 204916_at | 0.2425 | 0.8838 | |
| GSE20347 | RAMP1 | 10267 | 204916_at | 0.2933 | 0.1271 | |
| GSE23400 | RAMP1 | 10267 | 204916_at | -0.0661 | 0.6147 | |
| GSE26886 | RAMP1 | 10267 | 204916_at | 0.5529 | 0.0062 | |
| GSE29001 | RAMP1 | 10267 | 204916_at | 0.3459 | 0.3626 | |
| GSE38129 | RAMP1 | 10267 | 204916_at | -0.0319 | 0.9477 | |
| GSE45670 | RAMP1 | 10267 | 204916_at | -0.3519 | 0.1424 | |
| GSE53622 | RAMP1 | 10267 | 131802 | -0.0690 | 0.8008 | |
| GSE53624 | RAMP1 | 10267 | 131802 | 0.3332 | 0.0485 | |
| GSE63941 | RAMP1 | 10267 | 204916_at | -1.2532 | 0.1006 | |
| GSE77861 | RAMP1 | 10267 | 204916_at | 0.1211 | 0.4379 | |
| GSE97050 | RAMP1 | 10267 | A_23_P50946 | -0.3270 | 0.4881 | |
| SRP007169 | RAMP1 | 10267 | RNAseq | 2.7225 | 0.0045 | |
| SRP064894 | RAMP1 | 10267 | RNAseq | 0.8311 | 0.0674 | |
| SRP133303 | RAMP1 | 10267 | RNAseq | -0.4782 | 0.1535 | |
| SRP159526 | RAMP1 | 10267 | RNAseq | 1.2760 | 0.0354 | |
| SRP219564 | RAMP1 | 10267 | RNAseq | -0.2146 | 0.8513 | |
| TCGA | RAMP1 | 10267 | RNAseq | -0.8244 | 0.0003 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by RAMP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAMP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAMP1 | 10267 | 1 | 12 | 17 | |
| GSE20123 | RAMP1 | 10267 | 1 | 12 | 17 | |
| GSE43470 | RAMP1 | 10267 | 1 | 9 | 33 | |
| GSE46452 | RAMP1 | 10267 | 0 | 5 | 54 | |
| GSE47630 | RAMP1 | 10267 | 4 | 5 | 31 | |
| GSE54993 | RAMP1 | 10267 | 3 | 2 | 65 | |
| GSE54994 | RAMP1 | 10267 | 8 | 10 | 35 | |
| GSE60625 | RAMP1 | 10267 | 0 | 3 | 8 | |
| GSE74703 | RAMP1 | 10267 | 1 | 7 | 28 | |
| GSE74704 | RAMP1 | 10267 | 1 | 5 | 14 | |
| TCGA | RAMP1 | 10267 | 12 | 27 | 57 |
Total number of gains: 32; Total number of losses: 97; Total Number of normals: 359.
Somatic mutations of RAMP1:
Generating mutation plots.
Highly correlated genes for RAMP1:
Showing top 20/763 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAMP1 | GAL | 0.755758 | 3 | 0 | 3 |
| RAMP1 | CNIH3 | 0.751272 | 3 | 0 | 3 |
| RAMP1 | NDUFAF4 | 0.738632 | 3 | 0 | 3 |
| RAMP1 | RILPL1 | 0.73019 | 3 | 0 | 3 |
| RAMP1 | HERC2 | 0.713717 | 3 | 0 | 3 |
| RAMP1 | HES6 | 0.709674 | 3 | 0 | 3 |
| RAMP1 | ACTN1 | 0.709371 | 5 | 0 | 4 |
| RAMP1 | GALM | 0.707961 | 3 | 0 | 3 |
| RAMP1 | CXCL5 | 0.701782 | 3 | 0 | 3 |
| RAMP1 | STK38L | 0.701118 | 3 | 0 | 3 |
| RAMP1 | DMPK | 0.701014 | 4 | 0 | 3 |
| RAMP1 | HAND2 | 0.698909 | 4 | 0 | 4 |
| RAMP1 | CCDC59 | 0.697137 | 3 | 0 | 3 |
| RAMP1 | PDLIM7 | 0.69124 | 6 | 0 | 5 |
| RAMP1 | IFT140 | 0.686724 | 3 | 0 | 3 |
| RAMP1 | SETD3 | 0.685822 | 4 | 0 | 4 |
| RAMP1 | PLEKHB1 | 0.674724 | 6 | 0 | 5 |
| RAMP1 | EIF5B | 0.673589 | 3 | 0 | 3 |
| RAMP1 | DAPK3 | 0.673109 | 3 | 0 | 3 |
| RAMP1 | RRAS2 | 0.668702 | 3 | 0 | 3 |
For details and further investigation, click here
