| Full name: heparin binding EGF like growth factor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q31.3 | ||
| Entrez ID: 1839 | HGNC ID: HGNC:3059 | Ensembl Gene: ENSG00000113070 | OMIM ID: 126150 |
| Drug and gene relationship at DGIdb | |||
HBEGF involved pathways:
Expression of HBEGF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HBEGF | 1839 | 203821_at | -0.1002 | 0.9673 | |
| GSE20347 | HBEGF | 1839 | 38037_at | -0.6558 | 0.1088 | |
| GSE23400 | HBEGF | 1839 | 203821_at | -0.6707 | 0.0000 | |
| GSE26886 | HBEGF | 1839 | 38037_at | -0.4157 | 0.2427 | |
| GSE29001 | HBEGF | 1839 | 203821_at | -1.1227 | 0.0129 | |
| GSE38129 | HBEGF | 1839 | 203821_at | -0.5147 | 0.1424 | |
| GSE45670 | HBEGF | 1839 | 203821_at | 0.1954 | 0.6631 | |
| GSE53622 | HBEGF | 1839 | 7698 | -0.7074 | 0.0003 | |
| GSE53624 | HBEGF | 1839 | 7698 | -0.6909 | 0.0000 | |
| GSE63941 | HBEGF | 1839 | 203821_at | -0.1874 | 0.8950 | |
| GSE77861 | HBEGF | 1839 | 203821_at | 0.2623 | 0.5800 | |
| GSE97050 | HBEGF | 1839 | A_24_P140608 | 0.1613 | 0.5556 | |
| SRP007169 | HBEGF | 1839 | RNAseq | -0.4169 | 0.4840 | |
| SRP008496 | HBEGF | 1839 | RNAseq | -1.2519 | 0.0021 | |
| SRP064894 | HBEGF | 1839 | RNAseq | -0.4714 | 0.1992 | |
| SRP133303 | HBEGF | 1839 | RNAseq | 0.4088 | 0.2738 | |
| SRP159526 | HBEGF | 1839 | RNAseq | -0.2642 | 0.7539 | |
| SRP193095 | HBEGF | 1839 | RNAseq | 0.0866 | 0.8044 | |
| SRP219564 | HBEGF | 1839 | RNAseq | -0.2278 | 0.6822 | |
| TCGA | HBEGF | 1839 | RNAseq | -0.1248 | 0.3021 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by HBEGF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HBEGF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HBEGF | 1839 | 3 | 11 | 16 | |
| GSE20123 | HBEGF | 1839 | 4 | 11 | 15 | |
| GSE43470 | HBEGF | 1839 | 2 | 10 | 31 | |
| GSE46452 | HBEGF | 1839 | 0 | 27 | 32 | |
| GSE47630 | HBEGF | 1839 | 0 | 20 | 20 | |
| GSE54993 | HBEGF | 1839 | 9 | 1 | 60 | |
| GSE54994 | HBEGF | 1839 | 2 | 14 | 37 | |
| GSE60625 | HBEGF | 1839 | 0 | 0 | 11 | |
| GSE74703 | HBEGF | 1839 | 2 | 7 | 27 | |
| GSE74704 | HBEGF | 1839 | 3 | 5 | 12 | |
| TCGA | HBEGF | 1839 | 4 | 37 | 55 |
Total number of gains: 29; Total number of losses: 143; Total Number of normals: 316.
Somatic mutations of HBEGF:
Generating mutation plots.
Highly correlated genes for HBEGF:
Showing top 20/100 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HBEGF | TM4SF18 | 0.742487 | 3 | 0 | 3 |
| HBEGF | HUS1 | 0.701275 | 3 | 0 | 3 |
| HBEGF | STK17A | 0.691016 | 4 | 0 | 3 |
| HBEGF | CREB5 | 0.673675 | 3 | 0 | 3 |
| HBEGF | WSB1 | 0.663218 | 3 | 0 | 3 |
| HBEGF | PLK3 | 0.659987 | 8 | 0 | 7 |
| HBEGF | RBKS | 0.659268 | 3 | 0 | 3 |
| HBEGF | MCFD2 | 0.659209 | 4 | 0 | 3 |
| HBEGF | ROBO4 | 0.646583 | 4 | 0 | 3 |
| HBEGF | MPHOSPH6 | 0.641554 | 3 | 0 | 3 |
| HBEGF | PAPPA | 0.641101 | 3 | 0 | 3 |
| HBEGF | TNFRSF10D | 0.640159 | 3 | 0 | 3 |
| HBEGF | RELL2 | 0.632005 | 4 | 0 | 3 |
| HBEGF | PPRC1 | 0.626662 | 3 | 0 | 3 |
| HBEGF | IER3 | 0.61969 | 13 | 0 | 12 |
| HBEGF | NAA25 | 0.619579 | 3 | 0 | 3 |
| HBEGF | HAS3 | 0.619031 | 5 | 0 | 5 |
| HBEGF | C3orf62 | 0.614193 | 3 | 0 | 3 |
| HBEGF | AREG | 0.609837 | 10 | 0 | 8 |
| HBEGF | ABHD6 | 0.605053 | 5 | 0 | 4 |
For details and further investigation, click here
