| Full name: immediate early response 3 | Alias Symbol: IEX-1|DIF-2|PRG1|IEX-1L | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 8870 | HGNC ID: HGNC:5392 | Ensembl Gene: ENSG00000137331 | OMIM ID: 602996 |
| Drug and gene relationship at DGIdb | |||
Expression of IER3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IER3 | 8870 | 201631_s_at | -0.8380 | 0.5726 | |
| GSE20347 | IER3 | 8870 | 201631_s_at | -0.6501 | 0.0242 | |
| GSE23400 | IER3 | 8870 | 201631_s_at | -0.6199 | 0.0001 | |
| GSE26886 | IER3 | 8870 | 201631_s_at | -0.7531 | 0.1739 | |
| GSE29001 | IER3 | 8870 | 201631_s_at | -0.9423 | 0.0459 | |
| GSE38129 | IER3 | 8870 | 201631_s_at | -0.2692 | 0.4116 | |
| GSE45670 | IER3 | 8870 | 201631_s_at | 0.0042 | 0.9928 | |
| GSE53622 | IER3 | 8870 | 71363 | -0.3285 | 0.0538 | |
| GSE53624 | IER3 | 8870 | 71363 | -0.6889 | 0.0000 | |
| GSE63941 | IER3 | 8870 | 201631_s_at | 0.5714 | 0.5142 | |
| GSE77861 | IER3 | 8870 | 201631_s_at | 0.5132 | 0.1956 | |
| GSE97050 | IER3 | 8870 | A_33_P3423551 | 0.7033 | 0.0885 | |
| SRP007169 | IER3 | 8870 | RNAseq | -3.2946 | 0.0000 | |
| SRP008496 | IER3 | 8870 | RNAseq | -1.9876 | 0.0000 | |
| SRP064894 | IER3 | 8870 | RNAseq | -0.5712 | 0.0806 | |
| SRP133303 | IER3 | 8870 | RNAseq | -0.0918 | 0.7808 | |
| SRP159526 | IER3 | 8870 | RNAseq | 0.1089 | 0.8012 | |
| SRP193095 | IER3 | 8870 | RNAseq | 0.5349 | 0.0504 | |
| SRP219564 | IER3 | 8870 | RNAseq | 0.0241 | 0.9584 | |
| TCGA | IER3 | 8870 | RNAseq | 0.0468 | 0.6050 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by IER3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IER3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IER3 | 8870 | 5 | 1 | 24 | |
| GSE20123 | IER3 | 8870 | 5 | 1 | 24 | |
| GSE43470 | IER3 | 8870 | 5 | 1 | 37 | |
| GSE46452 | IER3 | 8870 | 1 | 10 | 48 | |
| GSE47630 | IER3 | 8870 | 7 | 3 | 30 | |
| GSE54993 | IER3 | 8870 | 2 | 1 | 67 | |
| GSE54994 | IER3 | 8870 | 11 | 4 | 38 | |
| GSE60625 | IER3 | 8870 | 0 | 1 | 10 | |
| GSE74703 | IER3 | 8870 | 5 | 0 | 31 | |
| GSE74704 | IER3 | 8870 | 2 | 0 | 18 | |
| TCGA | IER3 | 8870 | 18 | 16 | 62 |
Total number of gains: 61; Total number of losses: 38; Total Number of normals: 389.
Somatic mutations of IER3:
Generating mutation plots.
Highly correlated genes for IER3:
Showing top 20/120 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IER3 | CALY | 0.701278 | 3 | 0 | 3 |
| IER3 | APOBEC2 | 0.67642 | 3 | 0 | 3 |
| IER3 | ADAM11 | 0.670357 | 3 | 0 | 3 |
| IER3 | TRIM3 | 0.667191 | 3 | 0 | 3 |
| IER3 | RBKS | 0.65437 | 3 | 0 | 3 |
| IER3 | TAS2R38 | 0.645178 | 3 | 0 | 3 |
| IER3 | TNFAIP3 | 0.638821 | 5 | 0 | 4 |
| IER3 | FAM114A2 | 0.627192 | 4 | 0 | 3 |
| IER3 | DUSP6 | 0.626397 | 4 | 0 | 3 |
| IER3 | HBEGF | 0.61969 | 13 | 0 | 12 |
| IER3 | TNFRSF10C | 0.61136 | 3 | 0 | 3 |
| IER3 | TIPARP | 0.610574 | 8 | 0 | 7 |
| IER3 | ETF1 | 0.603592 | 4 | 0 | 3 |
| IER3 | F2RL1 | 0.602472 | 4 | 0 | 3 |
| IER3 | RYBP | 0.600924 | 3 | 0 | 3 |
| IER3 | SPRY1 | 0.600722 | 4 | 0 | 3 |
| IER3 | JUNB | 0.597126 | 13 | 0 | 11 |
| IER3 | BDKRB1 | 0.594555 | 10 | 0 | 7 |
| IER3 | CDKN1A | 0.594101 | 9 | 0 | 8 |
| IER3 | ZFP36 | 0.591539 | 8 | 0 | 4 |
For details and further investigation, click here
