| Full name: HR lysine demethylase and nuclear receptor corepressor | Alias Symbol: AU | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 55806 | HGNC ID: HGNC:5172 | Ensembl Gene: ENSG00000168453 | OMIM ID: 602302 |
| Drug and gene relationship at DGIdb | |||
Expression of HR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HR | 55806 | 241355_at | 1.1252 | 0.1253 | |
| GSE20347 | HR | 55806 | 210086_at | 0.4424 | 0.0078 | |
| GSE23400 | HR | 55806 | 210086_at | 0.3395 | 0.0060 | |
| GSE26886 | HR | 55806 | 241355_at | -0.0773 | 0.8544 | |
| GSE29001 | HR | 55806 | 210086_at | 0.1751 | 0.7512 | |
| GSE38129 | HR | 55806 | 210086_at | 0.2899 | 0.2145 | |
| GSE45670 | HR | 55806 | 241355_at | 0.7367 | 0.0208 | |
| GSE53622 | HR | 55806 | 66141 | 0.4403 | 0.0005 | |
| GSE53624 | HR | 55806 | 66141 | -0.0765 | 0.4730 | |
| GSE63941 | HR | 55806 | 241355_at | 0.6110 | 0.5287 | |
| GSE77861 | HR | 55806 | 241355_at | 0.5096 | 0.0635 | |
| GSE97050 | HR | 55806 | A_33_P3364060 | 0.9080 | 0.2372 | |
| SRP007169 | HR | 55806 | RNAseq | 1.3158 | 0.0454 | |
| SRP008496 | HR | 55806 | RNAseq | 0.9984 | 0.0294 | |
| SRP064894 | HR | 55806 | RNAseq | -0.0803 | 0.8236 | |
| SRP133303 | HR | 55806 | RNAseq | 0.3647 | 0.2525 | |
| SRP159526 | HR | 55806 | RNAseq | 0.8873 | 0.0694 | |
| SRP193095 | HR | 55806 | RNAseq | 0.2727 | 0.1279 | |
| SRP219564 | HR | 55806 | RNAseq | -0.8854 | 0.1663 | |
| TCGA | HR | 55806 | RNAseq | 0.3713 | 0.0019 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HR | 55806 | 4 | 10 | 16 | |
| GSE20123 | HR | 55806 | 4 | 10 | 16 | |
| GSE43470 | HR | 55806 | 4 | 9 | 30 | |
| GSE46452 | HR | 55806 | 13 | 13 | 33 | |
| GSE47630 | HR | 55806 | 10 | 8 | 22 | |
| GSE54993 | HR | 55806 | 2 | 14 | 54 | |
| GSE54994 | HR | 55806 | 8 | 18 | 27 | |
| GSE60625 | HR | 55806 | 3 | 0 | 8 | |
| GSE74703 | HR | 55806 | 4 | 7 | 25 | |
| GSE74704 | HR | 55806 | 3 | 7 | 10 | |
| TCGA | HR | 55806 | 13 | 43 | 40 |
Total number of gains: 68; Total number of losses: 139; Total Number of normals: 281.
Somatic mutations of HR:
Generating mutation plots.
Highly correlated genes for HR:
Showing top 20/341 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HR | CDCA2 | 0.775459 | 3 | 0 | 3 |
| HR | TMEM223 | 0.684555 | 5 | 0 | 5 |
| HR | C20orf27 | 0.68387 | 5 | 0 | 5 |
| HR | CDCA5 | 0.681836 | 4 | 0 | 4 |
| HR | DNTTIP1 | 0.681236 | 3 | 0 | 3 |
| HR | TSFM | 0.675474 | 3 | 0 | 3 |
| HR | TIMM22 | 0.669097 | 3 | 0 | 3 |
| HR | PSMG3 | 0.664688 | 4 | 0 | 3 |
| HR | CPSF3 | 0.652129 | 3 | 0 | 3 |
| HR | EME1 | 0.645934 | 4 | 0 | 3 |
| HR | GFM1 | 0.643711 | 3 | 0 | 3 |
| HR | CENPW | 0.641872 | 4 | 0 | 3 |
| HR | MKI67 | 0.64119 | 6 | 0 | 5 |
| HR | SART1 | 0.638172 | 3 | 0 | 3 |
| HR | BAZ2A | 0.637327 | 4 | 0 | 3 |
| HR | CCAR2 | 0.636782 | 4 | 0 | 3 |
| HR | RAI1 | 0.634641 | 4 | 0 | 4 |
| HR | SSTR5 | 0.63275 | 3 | 0 | 3 |
| HR | NIFK | 0.630158 | 3 | 0 | 3 |
| HR | CDT1 | 0.629976 | 6 | 0 | 5 |
For details and further investigation, click here
