| Full name: heparan sulfate-glucosamine 3-sulfotransferase 1 | Alias Symbol: 3OST1 | ||
| Type: protein-coding gene | Cytoband: 4p15.33 | ||
| Entrez ID: 9957 | HGNC ID: HGNC:5194 | Ensembl Gene: ENSG00000002587 | OMIM ID: 603244 |
| Drug and gene relationship at DGIdb | |||
Expression of HS3ST1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HS3ST1 | 9957 | 205466_s_at | -1.5170 | 0.1355 | |
| GSE20347 | HS3ST1 | 9957 | 205466_s_at | -2.5522 | 0.0000 | |
| GSE23400 | HS3ST1 | 9957 | 213991_s_at | -0.0763 | 0.0322 | |
| GSE26886 | HS3ST1 | 9957 | 205466_s_at | -3.5113 | 0.0000 | |
| GSE29001 | HS3ST1 | 9957 | 205466_s_at | -2.0002 | 0.0017 | |
| GSE38129 | HS3ST1 | 9957 | 205466_s_at | -1.6978 | 0.0001 | |
| GSE45670 | HS3ST1 | 9957 | 205466_s_at | 0.3621 | 0.4302 | |
| GSE53622 | HS3ST1 | 9957 | 106152 | -1.5896 | 0.0000 | |
| GSE53624 | HS3ST1 | 9957 | 106152 | -2.3174 | 0.0000 | |
| GSE63941 | HS3ST1 | 9957 | 205466_s_at | -0.2405 | 0.8757 | |
| GSE77861 | HS3ST1 | 9957 | 205466_s_at | -1.2150 | 0.0182 | |
| GSE97050 | HS3ST1 | 9957 | A_23_P121657 | 0.3234 | 0.5957 | |
| SRP007169 | HS3ST1 | 9957 | RNAseq | -2.1616 | 0.0079 | |
| SRP008496 | HS3ST1 | 9957 | RNAseq | -3.3389 | 0.0000 | |
| SRP064894 | HS3ST1 | 9957 | RNAseq | -2.0299 | 0.0000 | |
| SRP133303 | HS3ST1 | 9957 | RNAseq | -0.6919 | 0.0298 | |
| SRP159526 | HS3ST1 | 9957 | RNAseq | -1.8824 | 0.0000 | |
| SRP193095 | HS3ST1 | 9957 | RNAseq | -0.9024 | 0.0001 | |
| SRP219564 | HS3ST1 | 9957 | RNAseq | -1.7202 | 0.0097 | |
| TCGA | HS3ST1 | 9957 | RNAseq | -0.0950 | 0.5588 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by HS3ST1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HS3ST1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HS3ST1 | 9957 | 0 | 18 | 12 | |
| GSE20123 | HS3ST1 | 9957 | 0 | 18 | 12 | |
| GSE43470 | HS3ST1 | 9957 | 1 | 15 | 27 | |
| GSE46452 | HS3ST1 | 9957 | 1 | 36 | 22 | |
| GSE47630 | HS3ST1 | 9957 | 1 | 19 | 20 | |
| GSE54993 | HS3ST1 | 9957 | 10 | 0 | 60 | |
| GSE54994 | HS3ST1 | 9957 | 4 | 12 | 37 | |
| GSE60625 | HS3ST1 | 9957 | 0 | 0 | 11 | |
| GSE74703 | HS3ST1 | 9957 | 1 | 13 | 22 | |
| GSE74704 | HS3ST1 | 9957 | 0 | 11 | 9 | |
| TCGA | HS3ST1 | 9957 | 10 | 46 | 40 |
Total number of gains: 28; Total number of losses: 188; Total Number of normals: 272.
Somatic mutations of HS3ST1:
Generating mutation plots.
Highly correlated genes for HS3ST1:
Showing top 20/1403 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HS3ST1 | CXCR2 | 0.750149 | 9 | 0 | 9 |
| HS3ST1 | CAPN14 | 0.742259 | 7 | 0 | 7 |
| HS3ST1 | NMU | 0.740392 | 9 | 0 | 9 |
| HS3ST1 | GMDS | 0.737978 | 8 | 0 | 8 |
| HS3ST1 | RBM47 | 0.737707 | 10 | 0 | 10 |
| HS3ST1 | EPGN | 0.735647 | 3 | 0 | 3 |
| HS3ST1 | DENND2D | 0.730959 | 9 | 0 | 9 |
| HS3ST1 | LTA4H | 0.730091 | 3 | 0 | 3 |
| HS3ST1 | PLIN3 | 0.729782 | 9 | 0 | 9 |
| HS3ST1 | PRSS27 | 0.728851 | 7 | 0 | 7 |
| HS3ST1 | CEACAM1 | 0.728845 | 10 | 0 | 8 |
| HS3ST1 | PPP1R3C | 0.726691 | 10 | 0 | 9 |
| HS3ST1 | SGMS2 | 0.726156 | 4 | 0 | 4 |
| HS3ST1 | SLC16A6 | 0.725103 | 9 | 0 | 9 |
| HS3ST1 | CLCA4 | 0.722237 | 11 | 0 | 10 |
| HS3ST1 | EPHA2 | 0.713637 | 11 | 0 | 10 |
| HS3ST1 | MGLL | 0.712846 | 8 | 0 | 8 |
| HS3ST1 | CWH43 | 0.712732 | 9 | 0 | 8 |
| HS3ST1 | SPINK5 | 0.712533 | 10 | 0 | 8 |
| HS3ST1 | NIPAL1 | 0.712304 | 3 | 0 | 3 |
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