| Full name: hydroxysteroid 17-beta dehydrogenase 8 | Alias Symbol: HKE6|D6S2245E|RING2|KE6|H2-KE6|SDR30C1 | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 7923 | HGNC ID: HGNC:3554 | Ensembl Gene: ENSG00000204228 | OMIM ID: 601417 |
| Drug and gene relationship at DGIdb | |||
Expression of HSD17B8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD17B8 | 7923 | 213540_at | -0.5227 | 0.1376 | |
| GSE20347 | HSD17B8 | 7923 | 213540_at | -0.4007 | 0.0155 | |
| GSE23400 | HSD17B8 | 7923 | 213540_at | 0.0112 | 0.8930 | |
| GSE26886 | HSD17B8 | 7923 | 213540_at | -0.2991 | 0.1440 | |
| GSE29001 | HSD17B8 | 7923 | 213540_at | -0.2268 | 0.3987 | |
| GSE38129 | HSD17B8 | 7923 | 213540_at | -0.1266 | 0.4440 | |
| GSE45670 | HSD17B8 | 7923 | 213540_at | -0.3783 | 0.0241 | |
| GSE53622 | HSD17B8 | 7923 | 46934 | -0.4621 | 0.0001 | |
| GSE53624 | HSD17B8 | 7923 | 46934 | -0.4932 | 0.0000 | |
| GSE63941 | HSD17B8 | 7923 | 213540_at | 2.2264 | 0.0017 | |
| GSE77861 | HSD17B8 | 7923 | 213540_at | -0.2433 | 0.4764 | |
| GSE97050 | HSD17B8 | 7923 | A_23_P81973 | -0.1876 | 0.4597 | |
| SRP007169 | HSD17B8 | 7923 | RNAseq | -1.1842 | 0.0014 | |
| SRP008496 | HSD17B8 | 7923 | RNAseq | -1.1153 | 0.0001 | |
| SRP064894 | HSD17B8 | 7923 | RNAseq | -0.4358 | 0.1146 | |
| SRP133303 | HSD17B8 | 7923 | RNAseq | -0.5013 | 0.0335 | |
| SRP159526 | HSD17B8 | 7923 | RNAseq | -0.5185 | 0.0320 | |
| SRP193095 | HSD17B8 | 7923 | RNAseq | -0.9139 | 0.0000 | |
| SRP219564 | HSD17B8 | 7923 | RNAseq | -0.3641 | 0.3022 | |
| TCGA | HSD17B8 | 7923 | RNAseq | -0.0479 | 0.6103 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by HSD17B8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD17B8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD17B8 | 7923 | 5 | 0 | 25 | |
| GSE20123 | HSD17B8 | 7923 | 5 | 0 | 25 | |
| GSE43470 | HSD17B8 | 7923 | 4 | 1 | 38 | |
| GSE46452 | HSD17B8 | 7923 | 2 | 9 | 48 | |
| GSE47630 | HSD17B8 | 7923 | 8 | 4 | 28 | |
| GSE54993 | HSD17B8 | 7923 | 3 | 1 | 66 | |
| GSE54994 | HSD17B8 | 7923 | 11 | 4 | 38 | |
| GSE60625 | HSD17B8 | 7923 | 1 | 0 | 10 | |
| GSE74703 | HSD17B8 | 7923 | 4 | 0 | 32 | |
| GSE74704 | HSD17B8 | 7923 | 2 | 0 | 18 | |
| TCGA | HSD17B8 | 7923 | 15 | 16 | 65 |
Total number of gains: 60; Total number of losses: 35; Total Number of normals: 393.
Somatic mutations of HSD17B8:
Generating mutation plots.
Highly correlated genes for HSD17B8:
Showing top 20/332 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD17B8 | RPUSD1 | 0.711077 | 3 | 0 | 3 |
| HSD17B8 | MVB12A | 0.686263 | 5 | 0 | 4 |
| HSD17B8 | RNF144B | 0.657074 | 3 | 0 | 3 |
| HSD17B8 | TSEN54 | 0.651933 | 3 | 0 | 3 |
| HSD17B8 | C19orf33 | 0.651503 | 4 | 0 | 3 |
| HSD17B8 | MVK | 0.635094 | 3 | 0 | 3 |
| HSD17B8 | MYO5B | 0.632615 | 5 | 0 | 4 |
| HSD17B8 | CRB3 | 0.623292 | 6 | 0 | 5 |
| HSD17B8 | CLVS1 | 0.62056 | 3 | 0 | 3 |
| HSD17B8 | PPP1R13B | 0.615842 | 4 | 0 | 3 |
| HSD17B8 | HMGCS1 | 0.615058 | 5 | 0 | 5 |
| HSD17B8 | LINC00557 | 0.610385 | 3 | 0 | 3 |
| HSD17B8 | SLC27A4 | 0.606556 | 4 | 0 | 3 |
| HSD17B8 | SLC25A39 | 0.604978 | 5 | 0 | 4 |
| HSD17B8 | TTC22 | 0.601933 | 7 | 0 | 6 |
| HSD17B8 | S100A16 | 0.60124 | 7 | 0 | 5 |
| HSD17B8 | PPIL2 | 0.600849 | 3 | 0 | 3 |
| HSD17B8 | GRHL1 | 0.599641 | 5 | 0 | 4 |
| HSD17B8 | GSTZ1 | 0.59904 | 10 | 0 | 8 |
| HSD17B8 | COL6A5 | 0.597562 | 4 | 0 | 4 |
For details and further investigation, click here
