| Full name: heat shock protein family A (Hsp70) member 8 | Alias Symbol: HSC71|HSC70|HSP73 | ||
| Type: protein-coding gene | Cytoband: 11q24.1 | ||
| Entrez ID: 3312 | HGNC ID: HGNC:5241 | Ensembl Gene: ENSG00000109971 | OMIM ID: 600816 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
HSPA8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04213 | Longevity regulating pathway - multiple species | |
| hsa05134 | Legionellosis | |
| hsa05145 | Toxoplasmosis | |
| hsa05164 | Influenza A |
Expression of HSPA8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | HSPA8 | 3312 | 48284 | 0.3833 | 0.0000 | |
| GSE53624 | HSPA8 | 3312 | 48284 | 0.4982 | 0.0000 | |
| GSE97050 | HSPA8 | 3312 | A_33_P3390758 | 0.7265 | 0.0870 | |
| SRP007169 | HSPA8 | 3312 | RNAseq | -0.3752 | 0.3260 | |
| SRP008496 | HSPA8 | 3312 | RNAseq | -0.2194 | 0.3684 | |
| SRP064894 | HSPA8 | 3312 | RNAseq | 0.3579 | 0.0682 | |
| SRP133303 | HSPA8 | 3312 | RNAseq | 0.5569 | 0.0000 | |
| SRP159526 | HSPA8 | 3312 | RNAseq | 0.1255 | 0.7893 | |
| SRP193095 | HSPA8 | 3312 | RNAseq | -0.1291 | 0.3696 | |
| SRP219564 | HSPA8 | 3312 | RNAseq | -0.5991 | 0.3577 | |
| TCGA | HSPA8 | 3312 | RNAseq | -0.0975 | 0.0129 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSPA8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSPA8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSPA8 | 3312 | 0 | 13 | 17 | |
| GSE20123 | HSPA8 | 3312 | 0 | 13 | 17 | |
| GSE43470 | HSPA8 | 3312 | 2 | 7 | 34 | |
| GSE46452 | HSPA8 | 3312 | 3 | 26 | 30 | |
| GSE47630 | HSPA8 | 3312 | 2 | 19 | 19 | |
| GSE54993 | HSPA8 | 3312 | 10 | 0 | 60 | |
| GSE54994 | HSPA8 | 3312 | 5 | 19 | 29 | |
| GSE60625 | HSPA8 | 3312 | 0 | 3 | 8 | |
| GSE74703 | HSPA8 | 3312 | 1 | 5 | 30 | |
| GSE74704 | HSPA8 | 3312 | 0 | 9 | 11 | |
| TCGA | HSPA8 | 3312 | 5 | 50 | 41 |
Total number of gains: 28; Total number of losses: 164; Total Number of normals: 296.
Somatic mutations of HSPA8:
Generating mutation plots.
Highly correlated genes for HSPA8:
Showing top 20/121 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSPA8 | IMP4 | 0.727046 | 3 | 0 | 3 |
| HSPA8 | RPN1 | 0.719603 | 3 | 0 | 3 |
| HSPA8 | NOL11 | 0.714872 | 3 | 0 | 3 |
| HSPA8 | PHB | 0.710615 | 3 | 0 | 3 |
| HSPA8 | LLPH | 0.701564 | 3 | 0 | 3 |
| HSPA8 | YIF1A | 0.700201 | 3 | 0 | 3 |
| HSPA8 | SAAL1 | 0.700075 | 3 | 0 | 3 |
| HSPA8 | HSPH1 | 0.696912 | 3 | 0 | 3 |
| HSPA8 | DNAJA1 | 0.696901 | 3 | 0 | 3 |
| HSPA8 | NAA10 | 0.696515 | 3 | 0 | 3 |
| HSPA8 | DCAF13 | 0.685894 | 3 | 0 | 3 |
| HSPA8 | CCT2 | 0.679153 | 4 | 0 | 4 |
| HSPA8 | CNIH4 | 0.678342 | 3 | 0 | 3 |
| HSPA8 | SRM | 0.674398 | 3 | 0 | 3 |
| HSPA8 | KDM1A | 0.673249 | 3 | 0 | 3 |
| HSPA8 | CSE1L | 0.672451 | 3 | 0 | 3 |
| HSPA8 | XPOT | 0.66866 | 3 | 0 | 3 |
| HSPA8 | STIP1 | 0.666136 | 3 | 0 | 3 |
| HSPA8 | PTRH2 | 0.66389 | 3 | 0 | 3 |
| HSPA8 | TMEM138 | 0.66131 | 3 | 0 | 3 |
For details and further investigation, click here
