| Full name: 5-hydroxytryptamine receptor 5A | Alias Symbol: 5-HT5A | ||
| Type: protein-coding gene | Cytoband: 7q36.2 | ||
| Entrez ID: 3361 | HGNC ID: HGNC:5300 | Ensembl Gene: ENSG00000157219 | OMIM ID: 601305 |
| Drug and gene relationship at DGIdb | |||
HTR5A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04726 | Serotonergic synapse |
Expression of HTR5A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR5A | 3361 | 221362_at | -0.0547 | 0.8664 | |
| GSE20347 | HTR5A | 3361 | 221362_at | -0.0518 | 0.4842 | |
| GSE23400 | HTR5A | 3361 | 221362_at | -0.2220 | 0.0000 | |
| GSE26886 | HTR5A | 3361 | 221362_at | -0.1520 | 0.3069 | |
| GSE29001 | HTR5A | 3361 | 221362_at | -0.2041 | 0.1703 | |
| GSE38129 | HTR5A | 3361 | 221362_at | -0.1146 | 0.0546 | |
| GSE45670 | HTR5A | 3361 | 221362_at | 0.0285 | 0.8089 | |
| GSE53622 | HTR5A | 3361 | 23886 | 0.0972 | 0.2478 | |
| GSE53624 | HTR5A | 3361 | 23886 | 0.4102 | 0.0000 | |
| GSE63941 | HTR5A | 3361 | 221362_at | 0.1564 | 0.3067 | |
| GSE77861 | HTR5A | 3361 | 221362_at | -0.0918 | 0.2780 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HTR5A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTR5A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTR5A | 3361 | 3 | 3 | 24 | |
| GSE20123 | HTR5A | 3361 | 2 | 3 | 25 | |
| GSE43470 | HTR5A | 3361 | 2 | 5 | 36 | |
| GSE46452 | HTR5A | 3361 | 7 | 2 | 50 | |
| GSE47630 | HTR5A | 3361 | 6 | 9 | 25 | |
| GSE54993 | HTR5A | 3361 | 3 | 3 | 64 | |
| GSE54994 | HTR5A | 3361 | 6 | 8 | 39 | |
| GSE60625 | HTR5A | 3361 | 0 | 0 | 11 | |
| GSE74703 | HTR5A | 3361 | 2 | 4 | 30 | |
| GSE74704 | HTR5A | 3361 | 0 | 3 | 17 | |
| TCGA | HTR5A | 3361 | 27 | 26 | 43 |
Total number of gains: 58; Total number of losses: 66; Total Number of normals: 364.
Somatic mutations of HTR5A:
Generating mutation plots.
Highly correlated genes for HTR5A:
Showing top 20/585 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR5A | LIMD2 | 0.672334 | 3 | 0 | 3 |
| HTR5A | LAIR1 | 0.66894 | 3 | 0 | 3 |
| HTR5A | GALNT9 | 0.661758 | 3 | 0 | 3 |
| HTR5A | KRT3 | 0.660969 | 4 | 0 | 4 |
| HTR5A | WWP2 | 0.656181 | 3 | 0 | 3 |
| HTR5A | PHKG1 | 0.643823 | 4 | 0 | 3 |
| HTR5A | ZMAT4 | 0.640884 | 3 | 0 | 3 |
| HTR5A | LINC01169 | 0.637899 | 3 | 0 | 3 |
| HTR5A | VGF | 0.633722 | 3 | 0 | 3 |
| HTR5A | SHC3 | 0.627376 | 5 | 0 | 5 |
| HTR5A | TXNDC2 | 0.626842 | 5 | 0 | 4 |
| HTR5A | VWA5B2 | 0.621124 | 4 | 0 | 4 |
| HTR5A | P2RX1 | 0.613288 | 8 | 0 | 6 |
| HTR5A | UMOD | 0.613245 | 6 | 0 | 4 |
| HTR5A | POU2F2 | 0.613034 | 6 | 0 | 5 |
| HTR5A | STS | 0.612234 | 4 | 0 | 4 |
| HTR5A | RARA | 0.612179 | 4 | 0 | 3 |
| HTR5A | RABEP2 | 0.6112 | 4 | 0 | 4 |
| HTR5A | KCNK9 | 0.610555 | 3 | 0 | 3 |
| HTR5A | ADAM30 | 0.610159 | 5 | 0 | 5 |
For details and further investigation, click here
