| Full name: insulin like growth factor 2 mRNA binding protein 3 | Alias Symbol: IMP-3|CT98|IMP3 | ||
| Type: protein-coding gene | Cytoband: 7p15.3 | ||
| Entrez ID: 10643 | HGNC ID: HGNC:28868 | Ensembl Gene: ENSG00000136231 | OMIM ID: 608259 |
| Drug and gene relationship at DGIdb | |||
Expression of IGF2BP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IGF2BP3 | 10643 | 203820_s_at | 0.5252 | 0.8090 | |
| GSE20347 | IGF2BP3 | 10643 | 203820_s_at | 2.2547 | 0.0001 | |
| GSE23400 | IGF2BP3 | 10643 | 203820_s_at | 1.3296 | 0.0000 | |
| GSE26886 | IGF2BP3 | 10643 | 203820_s_at | 1.1084 | 0.1009 | |
| GSE29001 | IGF2BP3 | 10643 | 203820_s_at | 0.9031 | 0.2755 | |
| GSE38129 | IGF2BP3 | 10643 | 203820_s_at | 2.5638 | 0.0000 | |
| GSE45670 | IGF2BP3 | 10643 | 203820_s_at | 2.4165 | 0.0014 | |
| GSE63941 | IGF2BP3 | 10643 | 203820_s_at | 1.1909 | 0.2388 | |
| GSE77861 | IGF2BP3 | 10643 | 203820_s_at | 2.2685 | 0.0068 | |
| GSE97050 | IGF2BP3 | 10643 | A_23_P19987 | -1.0366 | 0.4788 | |
| SRP007169 | IGF2BP3 | 10643 | RNAseq | 2.2523 | 0.0000 | |
| SRP008496 | IGF2BP3 | 10643 | RNAseq | 2.4088 | 0.0005 | |
| SRP133303 | IGF2BP3 | 10643 | RNAseq | 2.6055 | 0.0000 | |
| SRP159526 | IGF2BP3 | 10643 | RNAseq | 2.1408 | 0.0001 | |
| SRP193095 | IGF2BP3 | 10643 | RNAseq | 2.1772 | 0.0000 | |
| SRP219564 | IGF2BP3 | 10643 | RNAseq | 0.9582 | 0.2943 | |
| TCGA | IGF2BP3 | 10643 | RNAseq | 2.3866 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by IGF2BP3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of IGF2BP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IGF2BP3 | 10643 | 17 | 1 | 12 | |
| GSE20123 | IGF2BP3 | 10643 | 17 | 1 | 12 | |
| GSE43470 | IGF2BP3 | 10643 | 4 | 0 | 39 | |
| GSE46452 | IGF2BP3 | 10643 | 10 | 2 | 47 | |
| GSE47630 | IGF2BP3 | 10643 | 9 | 1 | 30 | |
| GSE54993 | IGF2BP3 | 10643 | 0 | 6 | 64 | |
| GSE54994 | IGF2BP3 | 10643 | 20 | 3 | 30 | |
| GSE60625 | IGF2BP3 | 10643 | 0 | 0 | 11 | |
| GSE74703 | IGF2BP3 | 10643 | 4 | 0 | 32 | |
| GSE74704 | IGF2BP3 | 10643 | 11 | 1 | 8 | |
| TCGA | IGF2BP3 | 10643 | 56 | 4 | 36 |
Total number of gains: 148; Total number of losses: 19; Total Number of normals: 321.
Somatic mutations of IGF2BP3:
Generating mutation plots.
Highly correlated genes for IGF2BP3:
Showing top 20/237 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IGF2BP3 | DDIAS | 0.733745 | 3 | 0 | 3 |
| IGF2BP3 | TRIM59 | 0.683921 | 3 | 0 | 3 |
| IGF2BP3 | MTFR2 | 0.678225 | 4 | 0 | 4 |
| IGF2BP3 | IGF2BP2 | 0.677421 | 7 | 0 | 7 |
| IGF2BP3 | NUF2 | 0.658228 | 3 | 0 | 3 |
| IGF2BP3 | GDA | 0.649272 | 4 | 0 | 4 |
| IGF2BP3 | SAMD12 | 0.648373 | 3 | 0 | 3 |
| IGF2BP3 | DIP2B | 0.641662 | 3 | 0 | 3 |
| IGF2BP3 | RNF168 | 0.634839 | 4 | 0 | 3 |
| IGF2BP3 | TP63 | 0.633725 | 6 | 0 | 6 |
| IGF2BP3 | FOXM1 | 0.628812 | 7 | 0 | 6 |
| IGF2BP3 | CEP55 | 0.622645 | 7 | 0 | 6 |
| IGF2BP3 | IGSF9 | 0.619402 | 4 | 0 | 3 |
| IGF2BP3 | XPOT | 0.619151 | 6 | 0 | 5 |
| IGF2BP3 | LDHB | 0.615942 | 5 | 0 | 4 |
| IGF2BP3 | BUB1B | 0.613269 | 8 | 0 | 7 |
| IGF2BP3 | TTK | 0.612861 | 7 | 0 | 6 |
| IGF2BP3 | ASPM | 0.609815 | 7 | 0 | 6 |
| IGF2BP3 | KIF14 | 0.60955 | 7 | 0 | 5 |
| IGF2BP3 | DDX39A | 0.609345 | 5 | 0 | 3 |
For details and further investigation, click here
