| Full name: interleukin 11 | Alias Symbol: IL-11|AGIF | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 3589 | HGNC ID: HGNC:5966 | Ensembl Gene: ENSG00000095752 | OMIM ID: 147681 |
| Drug and gene relationship at DGIdb | |||
IL11 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of IL11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL11 | 3589 | 206926_s_at | 0.1066 | 0.7287 | |
| GSE20347 | IL11 | 3589 | 206926_s_at | 0.0690 | 0.5261 | |
| GSE23400 | IL11 | 3589 | 206926_s_at | -0.0245 | 0.3942 | |
| GSE26886 | IL11 | 3589 | 206926_s_at | 0.3949 | 0.0075 | |
| GSE29001 | IL11 | 3589 | 206926_s_at | -0.1079 | 0.6096 | |
| GSE38129 | IL11 | 3589 | 206926_s_at | -0.0987 | 0.4768 | |
| GSE45670 | IL11 | 3589 | 206926_s_at | 0.1434 | 0.1882 | |
| GSE53622 | IL11 | 3589 | 43289 | 2.5842 | 0.0000 | |
| GSE53624 | IL11 | 3589 | 43289 | 3.4642 | 0.0000 | |
| GSE63941 | IL11 | 3589 | 206926_s_at | -0.4569 | 0.0977 | |
| GSE77861 | IL11 | 3589 | 206926_s_at | 0.0994 | 0.5146 | |
| GSE97050 | IL11 | 3589 | A_33_P3243887 | 1.5112 | 0.1189 | |
| SRP007169 | IL11 | 3589 | RNAseq | 3.4688 | 0.0042 | |
| SRP133303 | IL11 | 3589 | RNAseq | 1.1369 | 0.0000 | |
| SRP159526 | IL11 | 3589 | RNAseq | 2.4571 | 0.0000 | |
| SRP193095 | IL11 | 3589 | RNAseq | 2.3934 | 0.0000 | |
| SRP219564 | IL11 | 3589 | RNAseq | 1.7601 | 0.0001 | |
| TCGA | IL11 | 3589 | RNAseq | 2.3372 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by IL11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL11 | 3589 | 3 | 4 | 23 | |
| GSE20123 | IL11 | 3589 | 3 | 3 | 24 | |
| GSE43470 | IL11 | 3589 | 3 | 11 | 29 | |
| GSE46452 | IL11 | 3589 | 45 | 1 | 13 | |
| GSE47630 | IL11 | 3589 | 8 | 6 | 26 | |
| GSE54993 | IL11 | 3589 | 17 | 4 | 49 | |
| GSE54994 | IL11 | 3589 | 4 | 13 | 36 | |
| GSE60625 | IL11 | 3589 | 9 | 0 | 2 | |
| GSE74703 | IL11 | 3589 | 3 | 7 | 26 | |
| GSE74704 | IL11 | 3589 | 3 | 1 | 16 | |
| TCGA | IL11 | 3589 | 20 | 14 | 62 |
Total number of gains: 118; Total number of losses: 64; Total Number of normals: 306.
Somatic mutations of IL11:
Generating mutation plots.
Highly correlated genes for IL11:
Showing top 20/692 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL11 | ZNF469 | 0.738604 | 5 | 0 | 5 |
| IL11 | IGF2BP2 | 0.734524 | 4 | 0 | 4 |
| IL11 | AMIGO2 | 0.730715 | 4 | 0 | 4 |
| IL11 | FAM89A | 0.71568 | 3 | 0 | 3 |
| IL11 | ZMIZ2 | 0.713807 | 3 | 0 | 3 |
| IL11 | CCDC9 | 0.699508 | 7 | 0 | 6 |
| IL11 | SNAP47 | 0.696061 | 3 | 0 | 3 |
| IL11 | RFX2 | 0.693247 | 4 | 0 | 3 |
| IL11 | ANLN | 0.685551 | 3 | 0 | 3 |
| IL11 | SPON2 | 0.684424 | 3 | 0 | 3 |
| IL11 | MMP3 | 0.683169 | 7 | 0 | 5 |
| IL11 | CORO1B | 0.681773 | 4 | 0 | 4 |
| IL11 | LAMC2 | 0.681375 | 5 | 0 | 4 |
| IL11 | CTHRC1 | 0.681223 | 5 | 0 | 4 |
| IL11 | PYCR2 | 0.680798 | 3 | 0 | 3 |
| IL11 | STC2 | 0.680702 | 5 | 0 | 5 |
| IL11 | GDF2 | 0.676045 | 6 | 0 | 6 |
| IL11 | CHST1 | 0.670032 | 4 | 0 | 3 |
| IL11 | MAPK15 | 0.669565 | 3 | 0 | 3 |
| IL11 | PNPT1 | 0.669236 | 3 | 0 | 3 |
For details and further investigation, click here
