| Full name: interleukin 36 beta | Alias Symbol: FIL1|IL-1H2|IL-1F8|FILI-(ETA)|IL1-ETA|IL1H2|MGC126880|MGC126882 | ||
| Type: protein-coding gene | Cytoband: 2q14.1 | ||
| Entrez ID: 27177 | HGNC ID: HGNC:15564 | Ensembl Gene: ENSG00000136696 | OMIM ID: 605508 |
| Drug and gene relationship at DGIdb | |||
Expression of IL36B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL36B | 27177 | 231755_at | -0.5792 | 0.1461 | |
| GSE26886 | IL36B | 27177 | 231755_at | -0.4114 | 0.0492 | |
| GSE45670 | IL36B | 27177 | 231755_at | 0.0515 | 0.8733 | |
| GSE53622 | IL36B | 27177 | 28253 | -0.6969 | 0.0136 | |
| GSE53624 | IL36B | 27177 | 28253 | -1.7886 | 0.0000 | |
| GSE63941 | IL36B | 27177 | 231755_at | 0.0773 | 0.5436 | |
| GSE77861 | IL36B | 27177 | 231755_at | -0.4185 | 0.0181 | |
| SRP007169 | IL36B | 27177 | RNAseq | -4.1566 | 0.0000 | |
| SRP064894 | IL36B | 27177 | RNAseq | -2.2267 | 0.0003 | |
| SRP133303 | IL36B | 27177 | RNAseq | -0.6804 | 0.4383 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by IL36B expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of IL36B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL36B | 27177 | 7 | 2 | 21 | |
| GSE20123 | IL36B | 27177 | 7 | 2 | 21 | |
| GSE43470 | IL36B | 27177 | 3 | 1 | 39 | |
| GSE46452 | IL36B | 27177 | 1 | 4 | 54 | |
| GSE47630 | IL36B | 27177 | 7 | 0 | 33 | |
| GSE54993 | IL36B | 27177 | 0 | 6 | 64 | |
| GSE54994 | IL36B | 27177 | 10 | 0 | 43 | |
| GSE60625 | IL36B | 27177 | 0 | 3 | 8 | |
| GSE74703 | IL36B | 27177 | 3 | 1 | 32 | |
| GSE74704 | IL36B | 27177 | 3 | 2 | 15 | |
| TCGA | IL36B | 27177 | 31 | 6 | 59 |
Total number of gains: 72; Total number of losses: 27; Total Number of normals: 389.
Somatic mutations of IL36B:
Generating mutation plots.
Highly correlated genes for IL36B:
Showing top 20/477 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL36B | CLDN17 | 0.732888 | 6 | 0 | 6 |
| IL36B | KLK7 | 0.727927 | 4 | 0 | 4 |
| IL36B | CTNNBIP1 | 0.72142 | 3 | 0 | 3 |
| IL36B | PRSS2 | 0.714007 | 3 | 0 | 3 |
| IL36B | LRRC20 | 0.695115 | 3 | 0 | 3 |
| IL36B | IL22RA1 | 0.68418 | 3 | 0 | 3 |
| IL36B | CRCT1 | 0.682712 | 5 | 0 | 4 |
| IL36B | TMEM40 | 0.682455 | 5 | 0 | 4 |
| IL36B | SLC5A1 | 0.67993 | 4 | 0 | 4 |
| IL36B | CDA | 0.678106 | 5 | 0 | 5 |
| IL36B | IL36RN | 0.676098 | 5 | 0 | 5 |
| IL36B | SBSN | 0.673541 | 5 | 0 | 4 |
| IL36B | CNFN | 0.67172 | 5 | 0 | 3 |
| IL36B | DSC2 | 0.670533 | 4 | 0 | 3 |
| IL36B | SPTLC1 | 0.670428 | 4 | 0 | 4 |
| IL36B | HCG22 | 0.667572 | 5 | 0 | 4 |
| IL36B | DOCK9 | 0.66678 | 4 | 0 | 4 |
| IL36B | KLK6 | 0.657022 | 4 | 0 | 4 |
| IL36B | KRT80 | 0.655213 | 5 | 0 | 3 |
| IL36B | PNLIPRP3 | 0.654533 | 3 | 0 | 3 |
For details and further investigation, click here
