| Full name: iroquois homeobox 5 | Alias Symbol: IRX-2a | ||
| Type: protein-coding gene | Cytoband: 16q12.2 | ||
| Entrez ID: 10265 | HGNC ID: HGNC:14361 | Ensembl Gene: ENSG00000176842 | OMIM ID: 606195 |
| Drug and gene relationship at DGIdb | |||
Expression of IRX5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRX5 | 10265 | 210239_at | -0.0992 | 0.9479 | |
| GSE20347 | IRX5 | 10265 | 210239_at | -0.8006 | 0.0013 | |
| GSE23400 | IRX5 | 10265 | 210239_at | -0.2524 | 0.0001 | |
| GSE26886 | IRX5 | 10265 | 210239_at | -0.9573 | 0.0016 | |
| GSE29001 | IRX5 | 10265 | 210239_at | -0.6400 | 0.0448 | |
| GSE38129 | IRX5 | 10265 | 210239_at | -0.3311 | 0.2451 | |
| GSE45670 | IRX5 | 10265 | 210239_at | -0.1222 | 0.6360 | |
| GSE53622 | IRX5 | 10265 | 57981 | -0.4835 | 0.0426 | |
| GSE53624 | IRX5 | 10265 | 57981 | -0.8207 | 0.0000 | |
| GSE63941 | IRX5 | 10265 | 210239_at | 1.3786 | 0.0205 | |
| GSE77861 | IRX5 | 10265 | 210239_at | -0.4558 | 0.3702 | |
| GSE97050 | IRX5 | 10265 | A_24_P48057 | -0.0204 | 0.9690 | |
| SRP007169 | IRX5 | 10265 | RNAseq | -2.6375 | 0.0000 | |
| SRP008496 | IRX5 | 10265 | RNAseq | -2.2735 | 0.0000 | |
| SRP064894 | IRX5 | 10265 | RNAseq | -0.9991 | 0.0049 | |
| SRP133303 | IRX5 | 10265 | RNAseq | -1.0673 | 0.0019 | |
| SRP159526 | IRX5 | 10265 | RNAseq | -0.9013 | 0.0706 | |
| SRP193095 | IRX5 | 10265 | RNAseq | -1.0359 | 0.0000 | |
| SRP219564 | IRX5 | 10265 | RNAseq | -0.4855 | 0.6643 | |
| TCGA | IRX5 | 10265 | RNAseq | 0.1761 | 0.3057 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by IRX5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IRX5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRX5 | 10265 | 3 | 1 | 26 | |
| GSE20123 | IRX5 | 10265 | 3 | 0 | 27 | |
| GSE43470 | IRX5 | 10265 | 2 | 7 | 34 | |
| GSE46452 | IRX5 | 10265 | 38 | 1 | 20 | |
| GSE47630 | IRX5 | 10265 | 10 | 8 | 22 | |
| GSE54993 | IRX5 | 10265 | 2 | 4 | 64 | |
| GSE54994 | IRX5 | 10265 | 7 | 10 | 36 | |
| GSE60625 | IRX5 | 10265 | 4 | 0 | 7 | |
| GSE74703 | IRX5 | 10265 | 2 | 4 | 30 | |
| GSE74704 | IRX5 | 10265 | 3 | 0 | 17 | |
| TCGA | IRX5 | 10265 | 26 | 12 | 58 |
Total number of gains: 100; Total number of losses: 47; Total Number of normals: 341.
Somatic mutations of IRX5:
Generating mutation plots.
Highly correlated genes for IRX5:
Showing top 20/319 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRX5 | MARVELD2 | 0.746755 | 3 | 0 | 3 |
| IRX5 | MIR205HG | 0.68199 | 4 | 0 | 3 |
| IRX5 | NSDHL | 0.658781 | 5 | 0 | 5 |
| IRX5 | SYTL1 | 0.657877 | 6 | 0 | 5 |
| IRX5 | RNPEP | 0.656048 | 5 | 0 | 4 |
| IRX5 | CAPNS2 | 0.653334 | 5 | 0 | 4 |
| IRX5 | ARAP2 | 0.641253 | 3 | 0 | 3 |
| IRX5 | RDH12 | 0.637261 | 6 | 0 | 5 |
| IRX5 | E2F2 | 0.626273 | 5 | 0 | 4 |
| IRX5 | RAPGEFL1 | 0.62075 | 9 | 0 | 7 |
| IRX5 | CXCL17 | 0.619997 | 8 | 0 | 6 |
| IRX5 | IRX3 | 0.613698 | 9 | 0 | 5 |
| IRX5 | CGN | 0.612959 | 4 | 0 | 3 |
| IRX5 | NDUFA3 | 0.609885 | 3 | 0 | 3 |
| IRX5 | MARS2 | 0.609851 | 3 | 0 | 3 |
| IRX5 | KIAA1522 | 0.60513 | 5 | 0 | 4 |
| IRX5 | POLR3B | 0.601529 | 9 | 0 | 7 |
| IRX5 | MACC1 | 0.599735 | 5 | 0 | 3 |
| IRX5 | GRAMD1C | 0.59915 | 8 | 0 | 6 |
| IRX5 | FXYD3 | 0.598893 | 5 | 0 | 4 |
For details and further investigation, click here
