KANSL1

 

Full name: KAT8 regulatory NSL complex subunit 1 Alias Symbol: DKFZP727C091|MSL1v1|CENP-36|NSL1
Type: protein-coding gene Cytoband: 17q21.31
Entrez ID: 284058 HGNC ID: HGNC:24565 Ensembl Gene: ENSG00000120071 OMIM ID: 612452
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 161/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of KANSL1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KANSL1 284058 225117_at -0.1472 0.5988
GSE26886 KANSL1 284058 225117_at 0.0229 0.9294
GSE45670 KANSL1 284058 225117_at -0.2039 0.0369
GSE53622 KANSL1 284058 119519 -0.4024 0.0000
GSE53624 KANSL1 284058 119519 -0.2445 0.0000
GSE63941 KANSL1 284058 225117_at 0.0422 0.8957
GSE77861 KANSL1 284058 225117_at 0.2406 0.3408
SRP007169 KANSL1 284058 RNAseq -0.4446 0.1270
SRP008496 KANSL1 284058 RNAseq -0.5393 0.0035
SRP064894 KANSL1 284058 RNAseq -0.2965 0.0886
SRP133303 KANSL1 284058 RNAseq -0.1169 0.2746
SRP159526 KANSL1 284058 RNAseq -0.2624 0.2525
SRP193095 KANSL1 284058 RNAseq -0.1321 0.1613
SRP219564 KANSL1 284058 RNAseq -0.3323 0.2210

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by KANSL1 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of KANSL1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KANSL1 284058 6 2 22
GSE20123 KANSL1 284058 6 2 22
GSE43470 KANSL1 284058 1 2 40
GSE46452 KANSL1 284058 32 0 27
GSE47630 KANSL1 284058 9 0 31
GSE54993 KANSL1 284058 3 4 63
GSE54994 KANSL1 284058 9 6 38
GSE60625 KANSL1 284058 4 0 7
GSE74703 KANSL1 284058 1 1 34
GSE74704 KANSL1 284058 4 1 15
TCGA KANSL1 284058 26 7 63

Total number of gains: 101; Total number of losses: 25; Total Number of normals: 362.  

 

Somatic mutations of KANSL1:

 

Generating mutation plots.

 

Highly correlated genes for KANSL1:

 

Showing top 20/106 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KANSL1DDX420.750884303
KANSL1SELENBP10.706309303
KANSL1CCNI0.678188303
KANSL1PCMTD10.666923303
KANSL1FBXO90.663982303
KANSL1EZH10.663825505
KANSL1NR3C20.640483403
KANSL1NHLRC30.6329303
KANSL1RPS60.62942303
KANSL1APPL10.622955303
KANSL1CALCOCO10.622386303
KANSL1CCDC28A0.620387404
KANSL1HEIH0.61551404
KANSL1ZADH20.613312403
KANSL1SPOP0.607539404
KANSL1DYM0.606232303
KANSL1GGA30.606027403
KANSL1CBX70.605761403
KANSL1CHPT10.601714303
KANSL1ZMAT10.599989503

For details and further investigation, click here