| Full name: kinase insert domain receptor | Alias Symbol: FLK1|VEGFR|VEGFR2|CD309 | ||
| Type: protein-coding gene | Cytoband: 4q12 | ||
| Entrez ID: 3791 | HGNC ID: HGNC:6307 | Ensembl Gene: ENSG00000128052 | OMIM ID: 191306 |
| Drug and gene relationship at DGIdb | |||
KDR involved pathways:
Expression of KDR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KDR | 3791 | 203934_at | 0.2288 | 0.7749 | |
| GSE20347 | KDR | 3791 | 203934_at | -0.0819 | 0.4191 | |
| GSE23400 | KDR | 3791 | 203934_at | 0.0644 | 0.0909 | |
| GSE26886 | KDR | 3791 | 203934_at | -0.6182 | 0.0631 | |
| GSE29001 | KDR | 3791 | 203934_at | -0.3326 | 0.2234 | |
| GSE38129 | KDR | 3791 | 203934_at | -0.1330 | 0.3893 | |
| GSE45670 | KDR | 3791 | 203934_at | -0.1947 | 0.4507 | |
| GSE53622 | KDR | 3791 | 40284 | -0.1131 | 0.2244 | |
| GSE53624 | KDR | 3791 | 40284 | 0.0624 | 0.5694 | |
| GSE63941 | KDR | 3791 | 203934_at | -0.2410 | 0.6708 | |
| GSE77861 | KDR | 3791 | 203934_at | 0.1387 | 0.4193 | |
| GSE97050 | KDR | 3791 | A_24_P71973 | 0.2725 | 0.4428 | |
| SRP007169 | KDR | 3791 | RNAseq | 1.2293 | 0.0088 | |
| SRP008496 | KDR | 3791 | RNAseq | 1.1377 | 0.0028 | |
| SRP064894 | KDR | 3791 | RNAseq | 0.3521 | 0.2922 | |
| SRP133303 | KDR | 3791 | RNAseq | 0.0949 | 0.5020 | |
| SRP159526 | KDR | 3791 | RNAseq | 0.0266 | 0.9563 | |
| SRP193095 | KDR | 3791 | RNAseq | 0.3719 | 0.0348 | |
| SRP219564 | KDR | 3791 | RNAseq | -0.0248 | 0.9690 | |
| TCGA | KDR | 3791 | RNAseq | -0.4272 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by KDR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KDR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KDR | 3791 | 3 | 11 | 16 | |
| GSE20123 | KDR | 3791 | 2 | 11 | 17 | |
| GSE43470 | KDR | 3791 | 0 | 14 | 29 | |
| GSE46452 | KDR | 3791 | 1 | 36 | 22 | |
| GSE47630 | KDR | 3791 | 1 | 18 | 21 | |
| GSE54993 | KDR | 3791 | 7 | 0 | 63 | |
| GSE54994 | KDR | 3791 | 2 | 10 | 41 | |
| GSE60625 | KDR | 3791 | 0 | 0 | 11 | |
| GSE74703 | KDR | 3791 | 0 | 12 | 24 | |
| GSE74704 | KDR | 3791 | 1 | 6 | 13 | |
| TCGA | KDR | 3791 | 20 | 26 | 50 |
Total number of gains: 37; Total number of losses: 144; Total Number of normals: 307.
Somatic mutations of KDR:
Generating mutation plots.
Highly correlated genes for KDR:
Showing top 20/287 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KDR | ROBO4 | 0.710145 | 4 | 0 | 4 |
| KDR | TM4SF18 | 0.696242 | 6 | 0 | 5 |
| KDR | RASGRF2 | 0.686877 | 3 | 0 | 3 |
| KDR | RASGRP3 | 0.679025 | 6 | 0 | 5 |
| KDR | PLEK | 0.669237 | 4 | 0 | 4 |
| KDR | PLVAP | 0.66263 | 10 | 0 | 9 |
| KDR | FLI1 | 0.662188 | 5 | 0 | 5 |
| KDR | CCDC102B | 0.645138 | 5 | 0 | 4 |
| KDR | SLC39A7 | 0.642319 | 3 | 0 | 3 |
| KDR | TEK | 0.64026 | 6 | 0 | 5 |
| KDR | TUBB2B | 0.633947 | 3 | 0 | 3 |
| KDR | ENPP2 | 0.632386 | 7 | 0 | 6 |
| KDR | CD93 | 0.631245 | 10 | 0 | 7 |
| KDR | CLEC14A | 0.623602 | 5 | 0 | 5 |
| KDR | RAMP2 | 0.622358 | 6 | 0 | 5 |
| KDR | ACVRL1 | 0.621838 | 6 | 0 | 5 |
| KDR | STAB1 | 0.621778 | 6 | 0 | 5 |
| KDR | BCL6B | 0.619144 | 3 | 0 | 3 |
| KDR | TIE1 | 0.618931 | 11 | 0 | 7 |
| KDR | PECAM1 | 0.61777 | 9 | 0 | 8 |
For details and further investigation, click here
