| Full name: kinesin light chain 2 | Alias Symbol: FLJ12387 | ||
| Type: protein-coding gene | Cytoband: 11q13.2 | ||
| Entrez ID: 64837 | HGNC ID: HGNC:20716 | Ensembl Gene: ENSG00000174996 | OMIM ID: 611729 |
| Drug and gene relationship at DGIdb | |||
KLC2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05132 | Salmonella infection |
Expression of KLC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLC2 | 64837 | 218906_x_at | 0.4681 | 0.2654 | |
| GSE20347 | KLC2 | 64837 | 218906_x_at | 0.5234 | 0.0074 | |
| GSE23400 | KLC2 | 64837 | 218906_x_at | 0.2799 | 0.0000 | |
| GSE26886 | KLC2 | 64837 | 218906_x_at | 0.9774 | 0.0000 | |
| GSE29001 | KLC2 | 64837 | 218906_x_at | 0.1787 | 0.6367 | |
| GSE38129 | KLC2 | 64837 | 218906_x_at | 0.4351 | 0.0053 | |
| GSE45670 | KLC2 | 64837 | 218906_x_at | 0.3786 | 0.0019 | |
| GSE53622 | KLC2 | 64837 | 39756 | 0.6921 | 0.0000 | |
| GSE53624 | KLC2 | 64837 | 39756 | 0.6505 | 0.0000 | |
| GSE63941 | KLC2 | 64837 | 218906_x_at | 0.5097 | 0.3005 | |
| GSE77861 | KLC2 | 64837 | 218906_x_at | 0.5524 | 0.0064 | |
| GSE97050 | KLC2 | 64837 | A_33_P3219895 | -0.2219 | 0.2636 | |
| SRP007169 | KLC2 | 64837 | RNAseq | 1.3965 | 0.0319 | |
| SRP008496 | KLC2 | 64837 | RNAseq | 1.4084 | 0.0019 | |
| SRP064894 | KLC2 | 64837 | RNAseq | 0.4718 | 0.0028 | |
| SRP133303 | KLC2 | 64837 | RNAseq | 0.9040 | 0.0013 | |
| SRP159526 | KLC2 | 64837 | RNAseq | 0.9947 | 0.0000 | |
| SRP193095 | KLC2 | 64837 | RNAseq | 0.9475 | 0.0000 | |
| SRP219564 | KLC2 | 64837 | RNAseq | 0.3159 | 0.4449 | |
| TCGA | KLC2 | 64837 | RNAseq | 0.2368 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by KLC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLC2 | 64837 | 9 | 4 | 17 | |
| GSE20123 | KLC2 | 64837 | 9 | 4 | 17 | |
| GSE43470 | KLC2 | 64837 | 6 | 1 | 36 | |
| GSE46452 | KLC2 | 64837 | 11 | 3 | 45 | |
| GSE47630 | KLC2 | 64837 | 8 | 5 | 27 | |
| GSE54993 | KLC2 | 64837 | 3 | 0 | 67 | |
| GSE54994 | KLC2 | 64837 | 8 | 5 | 40 | |
| GSE60625 | KLC2 | 64837 | 0 | 3 | 8 | |
| GSE74703 | KLC2 | 64837 | 4 | 0 | 32 | |
| GSE74704 | KLC2 | 64837 | 7 | 2 | 11 | |
| TCGA | KLC2 | 64837 | 25 | 6 | 65 |
Total number of gains: 90; Total number of losses: 33; Total Number of normals: 365.
Somatic mutations of KLC2:
Generating mutation plots.
Highly correlated genes for KLC2:
Showing top 20/527 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLC2 | MNT | 0.754713 | 3 | 0 | 3 |
| KLC2 | KHSRP | 0.707941 | 8 | 0 | 8 |
| KLC2 | ZBTB2 | 0.698402 | 3 | 0 | 3 |
| KLC2 | COL12A1 | 0.687533 | 3 | 0 | 3 |
| KLC2 | ZFP92 | 0.679805 | 4 | 0 | 4 |
| KLC2 | NSMF | 0.679724 | 3 | 0 | 3 |
| KLC2 | STRADA | 0.67909 | 4 | 0 | 3 |
| KLC2 | TPPP3 | 0.676401 | 3 | 0 | 3 |
| KLC2 | NAA60 | 0.676114 | 3 | 0 | 3 |
| KLC2 | YWHAG | 0.675794 | 4 | 0 | 4 |
| KLC2 | GRAMD1A | 0.67523 | 3 | 0 | 3 |
| KLC2 | FBLIM1 | 0.675219 | 6 | 0 | 5 |
| KLC2 | CD276 | 0.666718 | 4 | 0 | 4 |
| KLC2 | TNPO1 | 0.663651 | 5 | 0 | 5 |
| KLC2 | TAF1 | 0.662691 | 3 | 0 | 3 |
| KLC2 | HOXC9 | 0.659409 | 4 | 0 | 3 |
| KLC2 | NTMT1 | 0.657119 | 4 | 0 | 4 |
| KLC2 | PCIF1 | 0.656176 | 3 | 0 | 3 |
| KLC2 | FOXD2-AS1 | 0.653541 | 3 | 0 | 3 |
| KLC2 | GADD45GIP1 | 0.650879 | 7 | 0 | 4 |
For details and further investigation, click here
