| Full name: marginal zone B and B1 cell specific protein | Alias Symbol: PACAP|MGC29506|HSPC190|pERp1|MEDA-7 | ||
| Type: protein-coding gene | Cytoband: 5q31.2 | ||
| Entrez ID: 51237 | HGNC ID: HGNC:30125 | Ensembl Gene: ENSG00000170476 | OMIM ID: 609447 |
| Drug and gene relationship at DGIdb | |||
Expression of MZB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MZB1 | 51237 | 221286_s_at | 0.0444 | 0.9765 | |
| GSE20347 | MZB1 | 51237 | 221286_s_at | 0.3136 | 0.0377 | |
| GSE23400 | MZB1 | 51237 | 221286_s_at | 0.0702 | 0.3502 | |
| GSE26886 | MZB1 | 51237 | 221286_s_at | 0.2138 | 0.1050 | |
| GSE29001 | MZB1 | 51237 | 221286_s_at | -0.0701 | 0.7071 | |
| GSE38129 | MZB1 | 51237 | 221286_s_at | 0.4133 | 0.0745 | |
| GSE45670 | MZB1 | 51237 | 221286_s_at | 0.2828 | 0.4703 | |
| GSE53622 | MZB1 | 51237 | 40736 | 0.6746 | 0.0297 | |
| GSE53624 | MZB1 | 51237 | 40736 | -0.1521 | 0.6015 | |
| GSE63941 | MZB1 | 51237 | 221286_s_at | 0.3424 | 0.0126 | |
| GSE77861 | MZB1 | 51237 | 221286_s_at | 0.4087 | 0.0139 | |
| GSE97050 | MZB1 | 51237 | A_23_P84596 | 1.7389 | 0.1660 | |
| SRP064894 | MZB1 | 51237 | RNAseq | 0.1739 | 0.7660 | |
| SRP133303 | MZB1 | 51237 | RNAseq | 0.3757 | 0.5051 | |
| SRP159526 | MZB1 | 51237 | RNAseq | 1.2951 | 0.3928 | |
| SRP219564 | MZB1 | 51237 | RNAseq | 2.0898 | 0.0018 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MZB1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of MZB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MZB1 | 51237 | 3 | 11 | 16 | |
| GSE20123 | MZB1 | 51237 | 4 | 11 | 15 | |
| GSE43470 | MZB1 | 51237 | 4 | 7 | 32 | |
| GSE46452 | MZB1 | 51237 | 0 | 27 | 32 | |
| GSE47630 | MZB1 | 51237 | 0 | 21 | 19 | |
| GSE54993 | MZB1 | 51237 | 9 | 1 | 60 | |
| GSE54994 | MZB1 | 51237 | 2 | 14 | 37 | |
| GSE60625 | MZB1 | 51237 | 0 | 0 | 11 | |
| GSE74703 | MZB1 | 51237 | 3 | 5 | 28 | |
| GSE74704 | MZB1 | 51237 | 3 | 5 | 12 | |
| TCGA | MZB1 | 51237 | 5 | 36 | 55 |
Total number of gains: 33; Total number of losses: 138; Total Number of normals: 317.
Somatic mutations of MZB1:
Generating mutation plots.
Highly correlated genes for MZB1:
Showing top 20/298 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MZB1 | MEI1 | 0.829654 | 5 | 0 | 5 |
| MZB1 | FCRL5 | 0.829357 | 5 | 0 | 5 |
| MZB1 | SLAMF6 | 0.759284 | 3 | 0 | 3 |
| MZB1 | LAX1 | 0.750171 | 8 | 0 | 8 |
| MZB1 | TNFRSF17 | 0.743645 | 10 | 0 | 9 |
| MZB1 | IGK | 0.743455 | 8 | 0 | 8 |
| MZB1 | MCM2 | 0.739835 | 3 | 0 | 3 |
| MZB1 | TBXAS1 | 0.721145 | 5 | 0 | 5 |
| MZB1 | SNX20 | 0.711546 | 4 | 0 | 4 |
| MZB1 | CD79A | 0.710664 | 10 | 0 | 8 |
| MZB1 | CD27 | 0.708847 | 8 | 0 | 7 |
| MZB1 | TSPO2 | 0.707715 | 3 | 0 | 3 |
| MZB1 | MYBBP1A | 0.688157 | 3 | 0 | 3 |
| MZB1 | ABI3 | 0.683178 | 4 | 0 | 3 |
| MZB1 | BTLA | 0.682875 | 4 | 0 | 4 |
| MZB1 | FCRL1 | 0.678108 | 5 | 0 | 5 |
| MZB1 | UBE2S | 0.673615 | 3 | 0 | 3 |
| MZB1 | VAC14 | 0.671423 | 3 | 0 | 3 |
| MZB1 | S1PR4 | 0.66828 | 5 | 0 | 4 |
| MZB1 | AKNA | 0.667349 | 4 | 0 | 3 |
For details and further investigation, click here
