| Full name: L-2-hydroxyglutarate dehydrogenase | Alias Symbol: FLJ12618 | ||
| Type: protein-coding gene | Cytoband: 14q21.3 | ||
| Entrez ID: 79944 | HGNC ID: HGNC:20499 | Ensembl Gene: ENSG00000087299 | OMIM ID: 609584 |
| Drug and gene relationship at DGIdb | |||
Expression of L2HGDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | L2HGDH | 79944 | 224460_s_at | 0.1517 | 0.8618 | |
| GSE20347 | L2HGDH | 79944 | 220089_at | 0.1276 | 0.4492 | |
| GSE23400 | L2HGDH | 79944 | 220089_at | 0.0892 | 0.0062 | |
| GSE26886 | L2HGDH | 79944 | 224460_s_at | -0.7426 | 0.0001 | |
| GSE29001 | L2HGDH | 79944 | 220089_at | 0.1707 | 0.4899 | |
| GSE38129 | L2HGDH | 79944 | 220089_at | 0.0948 | 0.5287 | |
| GSE45670 | L2HGDH | 79944 | 220089_at | 0.2729 | 0.0516 | |
| GSE53622 | L2HGDH | 79944 | 97022 | 0.2537 | 0.0241 | |
| GSE53624 | L2HGDH | 79944 | 97022 | 0.3493 | 0.0000 | |
| GSE63941 | L2HGDH | 79944 | 224460_s_at | 3.5138 | 0.0001 | |
| GSE77861 | L2HGDH | 79944 | 224460_s_at | 0.1932 | 0.4942 | |
| GSE97050 | L2HGDH | 79944 | A_33_P3310232 | -0.1427 | 0.6539 | |
| SRP007169 | L2HGDH | 79944 | RNAseq | -0.2071 | 0.5403 | |
| SRP008496 | L2HGDH | 79944 | RNAseq | -0.1615 | 0.5543 | |
| SRP064894 | L2HGDH | 79944 | RNAseq | -1.1840 | 0.0000 | |
| SRP133303 | L2HGDH | 79944 | RNAseq | -0.1915 | 0.1185 | |
| SRP159526 | L2HGDH | 79944 | RNAseq | -0.7374 | 0.0044 | |
| SRP193095 | L2HGDH | 79944 | RNAseq | -0.6076 | 0.0000 | |
| SRP219564 | L2HGDH | 79944 | RNAseq | -0.4391 | 0.3247 | |
| TCGA | L2HGDH | 79944 | RNAseq | -0.0246 | 0.7091 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by L2HGDH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of L2HGDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | L2HGDH | 79944 | 9 | 2 | 19 | |
| GSE20123 | L2HGDH | 79944 | 9 | 3 | 18 | |
| GSE43470 | L2HGDH | 79944 | 8 | 1 | 34 | |
| GSE46452 | L2HGDH | 79944 | 16 | 3 | 40 | |
| GSE47630 | L2HGDH | 79944 | 11 | 10 | 19 | |
| GSE54993 | L2HGDH | 79944 | 3 | 9 | 58 | |
| GSE54994 | L2HGDH | 79944 | 19 | 4 | 30 | |
| GSE60625 | L2HGDH | 79944 | 0 | 2 | 9 | |
| GSE74703 | L2HGDH | 79944 | 7 | 1 | 28 | |
| GSE74704 | L2HGDH | 79944 | 4 | 2 | 14 | |
| TCGA | L2HGDH | 79944 | 34 | 13 | 49 |
Total number of gains: 120; Total number of losses: 50; Total Number of normals: 318.
Somatic mutations of L2HGDH:
Generating mutation plots.
Highly correlated genes for L2HGDH:
Showing top 20/44 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| L2HGDH | DEPDC1B | 0.645634 | 3 | 0 | 3 |
| L2HGDH | BCYRN1 | 0.640381 | 3 | 0 | 3 |
| L2HGDH | GEMIN2 | 0.638121 | 6 | 0 | 4 |
| L2HGDH | RNF41 | 0.62752 | 3 | 0 | 3 |
| L2HGDH | SAPCD2 | 0.620649 | 3 | 0 | 3 |
| L2HGDH | CYB5B | 0.615027 | 3 | 0 | 3 |
| L2HGDH | MRPL42 | 0.611436 | 6 | 0 | 5 |
| L2HGDH | SDR42E1 | 0.604317 | 3 | 0 | 3 |
| L2HGDH | SUV39H2 | 0.600719 | 4 | 0 | 4 |
| L2HGDH | CCDC138 | 0.590026 | 3 | 0 | 3 |
| L2HGDH | RBM28 | 0.586825 | 5 | 0 | 4 |
| L2HGDH | MRPS16 | 0.584434 | 8 | 0 | 6 |
| L2HGDH | ORC1 | 0.583574 | 5 | 0 | 3 |
| L2HGDH | TFAP2C | 0.579385 | 5 | 0 | 3 |
| L2HGDH | LRR1 | 0.578561 | 4 | 0 | 4 |
| L2HGDH | POLE2 | 0.578183 | 7 | 0 | 4 |
| L2HGDH | LINC00355 | 0.572824 | 4 | 0 | 3 |
| L2HGDH | PAXIP1 | 0.571969 | 4 | 0 | 3 |
| L2HGDH | CNIH1 | 0.570956 | 7 | 0 | 4 |
| L2HGDH | ALYREF | 0.557494 | 4 | 0 | 3 |
For details and further investigation, click here
