LIG1

 

Full name: DNA ligase 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 19q13.33
Entrez ID: 3978 HGNC ID: HGNC:6598 Ensembl Gene: ENSG00000105486 OMIM ID: 126391
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of LIG1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LIG1 3978 202726_at 0.7311 0.1068
GSE20347 LIG1 3978 202726_at 0.4105 0.0016
GSE23400 LIG1 3978 202726_at 0.3534 0.0000
GSE26886 LIG1 3978 202726_at 0.2363 0.1507
GSE29001 LIG1 3978 202726_at 0.5241 0.0487
GSE38129 LIG1 3978 202726_at 0.7161 0.0000
GSE45670 LIG1 3978 202726_at 0.4390 0.0054
GSE53622 LIG1 3978 73184 0.5017 0.0000
GSE53624 LIG1 3978 141564 0.5859 0.0000
GSE63941 LIG1 3978 202726_at 0.9942 0.0062
GSE77861 LIG1 3978 202726_at 0.1828 0.2176
GSE97050 LIG1 3978 A_23_P39116 0.6929 0.1239
SRP007169 LIG1 3978 RNAseq 1.8090 0.0008
SRP008496 LIG1 3978 RNAseq 2.0896 0.0000
SRP064894 LIG1 3978 RNAseq 0.9933 0.0004
SRP133303 LIG1 3978 RNAseq 0.4869 0.0315
SRP159526 LIG1 3978 RNAseq 1.0030 0.0144
SRP193095 LIG1 3978 RNAseq 0.5373 0.0000
SRP219564 LIG1 3978 RNAseq 1.0631 0.0387
TCGA LIG1 3978 RNAseq 0.5216 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by LIG1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LIG1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LIG1 3978 4 4 22
GSE20123 LIG1 3978 4 3 23
GSE43470 LIG1 3978 3 10 30
GSE46452 LIG1 3978 45 1 13
GSE47630 LIG1 3978 8 7 25
GSE54993 LIG1 3978 17 4 49
GSE54994 LIG1 3978 4 14 35
GSE60625 LIG1 3978 9 0 2
GSE74703 LIG1 3978 3 7 26
GSE74704 LIG1 3978 4 1 15
TCGA LIG1 3978 15 19 62

Total number of gains: 116; Total number of losses: 70; Total Number of normals: 302.  

 

Somatic mutations of LIG1:

 

Generating mutation plots.

 

Highly correlated genes for LIG1:

 

Showing top 20/814 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LIG1C19orf480.725521303
LIG1IQGAP30.695828505
LIG1SPC250.695085909
LIG1PAFAH1B30.69277412011
LIG1MCM50.69048311010
LIG1UCN20.688708303
LIG1XXYLT10.688601404
LIG1FANCD20.688461505
LIG1ZNF6230.686214403
LIG1TRIM280.68475611010
LIG1RNASEH2A0.68305610010
LIG1TICRR0.682865404
LIG1UHRF10.682374707
LIG1SYT140.679128303
LIG1POLD10.6750621108
LIG1MKI670.6734531007
LIG1NDUFB90.67306303
LIG1CDCA80.67172311011
LIG1TOP2A0.67078911011
LIG1EXO10.6696071009

For details and further investigation, click here