| Full name: lipase A, lysosomal acid type | Alias Symbol: LAL|CESD | ||
| Type: protein-coding gene | Cytoband: 10q23.31 | ||
| Entrez ID: 3988 | HGNC ID: HGNC:6617 | Ensembl Gene: ENSG00000107798 | OMIM ID: 613497 |
| Drug and gene relationship at DGIdb | |||
Expression of LIPA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIPA | 3988 | 201847_at | 0.6117 | 0.0965 | |
| GSE20347 | LIPA | 3988 | 201847_at | 0.2886 | 0.1083 | |
| GSE23400 | LIPA | 3988 | 201847_at | 0.7247 | 0.0000 | |
| GSE26886 | LIPA | 3988 | 201847_at | 0.0137 | 0.9633 | |
| GSE29001 | LIPA | 3988 | 201847_at | 0.4406 | 0.1501 | |
| GSE38129 | LIPA | 3988 | 201847_at | 0.4627 | 0.0068 | |
| GSE45670 | LIPA | 3988 | 201847_at | 0.1855 | 0.3048 | |
| GSE53622 | LIPA | 3988 | 6719 | 0.4518 | 0.0000 | |
| GSE53624 | LIPA | 3988 | 6719 | 0.5628 | 0.0000 | |
| GSE63941 | LIPA | 3988 | 201847_at | 0.0609 | 0.9353 | |
| GSE77861 | LIPA | 3988 | 201847_at | 0.1163 | 0.8141 | |
| GSE97050 | LIPA | 3988 | A_23_P97860 | 0.7426 | 0.1170 | |
| SRP007169 | LIPA | 3988 | RNAseq | 0.9436 | 0.1009 | |
| SRP008496 | LIPA | 3988 | RNAseq | 0.6405 | 0.0488 | |
| SRP064894 | LIPA | 3988 | RNAseq | 1.4477 | 0.0000 | |
| SRP133303 | LIPA | 3988 | RNAseq | 0.9443 | 0.0000 | |
| SRP159526 | LIPA | 3988 | RNAseq | 0.5379 | 0.3744 | |
| SRP193095 | LIPA | 3988 | RNAseq | -0.0894 | 0.6430 | |
| SRP219564 | LIPA | 3988 | RNAseq | 1.3914 | 0.0235 | |
| TCGA | LIPA | 3988 | RNAseq | 0.1913 | 0.0009 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LIPA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LIPA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIPA | 3988 | 2 | 7 | 21 | |
| GSE20123 | LIPA | 3988 | 2 | 6 | 22 | |
| GSE43470 | LIPA | 3988 | 0 | 8 | 35 | |
| GSE46452 | LIPA | 3988 | 0 | 11 | 48 | |
| GSE47630 | LIPA | 3988 | 2 | 14 | 24 | |
| GSE54993 | LIPA | 3988 | 7 | 0 | 63 | |
| GSE54994 | LIPA | 3988 | 1 | 11 | 41 | |
| GSE60625 | LIPA | 3988 | 0 | 0 | 11 | |
| GSE74703 | LIPA | 3988 | 0 | 6 | 30 | |
| GSE74704 | LIPA | 3988 | 1 | 4 | 15 | |
| TCGA | LIPA | 3988 | 8 | 27 | 61 |
Total number of gains: 23; Total number of losses: 94; Total Number of normals: 371.
Somatic mutations of LIPA:
Generating mutation plots.
Highly correlated genes for LIPA:
Showing top 20/1051 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIPA | CERKL | 0.735275 | 3 | 0 | 3 |
| LIPA | AGPAT5 | 0.722006 | 3 | 0 | 3 |
| LIPA | LANCL2 | 0.697511 | 3 | 0 | 3 |
| LIPA | KDM1B | 0.684083 | 3 | 0 | 3 |
| LIPA | PPP1CA | 0.683527 | 3 | 0 | 3 |
| LIPA | TUBGCP4 | 0.682701 | 3 | 0 | 3 |
| LIPA | ZNF469 | 0.682526 | 4 | 0 | 3 |
| LIPA | CSRP2 | 0.678969 | 3 | 0 | 3 |
| LIPA | PSMA2 | 0.67806 | 9 | 0 | 8 |
| LIPA | SUSD1 | 0.676682 | 4 | 0 | 3 |
| LIPA | MEPCE | 0.67529 | 3 | 0 | 3 |
| LIPA | FAM160B1 | 0.675187 | 3 | 0 | 3 |
| LIPA | TLK2 | 0.671376 | 3 | 0 | 3 |
| LIPA | HSPA14 | 0.665 | 4 | 0 | 3 |
| LIPA | HAVCR2 | 0.663539 | 4 | 0 | 3 |
| LIPA | FMNL3 | 0.66133 | 5 | 0 | 4 |
| LIPA | U2SURP | 0.660648 | 3 | 0 | 3 |
| LIPA | HSD3B7 | 0.657303 | 4 | 0 | 4 |
| LIPA | SH3PXD2B | 0.657054 | 4 | 0 | 3 |
| LIPA | ST8SIA4 | 0.655434 | 5 | 0 | 5 |
For details and further investigation, click here
