| Full name: matrix metallopeptidase 13 | Alias Symbol: CLG3 | ||
| Type: protein-coding gene | Cytoband: 11q22.2 | ||
| Entrez ID: 4322 | HGNC ID: HGNC:7159 | Ensembl Gene: ENSG00000137745 | OMIM ID: 600108 |
| Drug and gene relationship at DGIdb | |||
Expression of MMP13:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP13 | 4322 | 205959_at | 3.4204 | 0.0054 | |
| GSE20347 | MMP13 | 4322 | 205959_at | 2.5853 | 0.0001 | |
| GSE23400 | MMP13 | 4322 | 205959_at | 1.2945 | 0.0000 | |
| GSE26886 | MMP13 | 4322 | 205959_at | 3.4807 | 0.0001 | |
| GSE29001 | MMP13 | 4322 | 205959_at | 2.5104 | 0.0028 | |
| GSE38129 | MMP13 | 4322 | 205959_at | 2.5903 | 0.0000 | |
| GSE45670 | MMP13 | 4322 | 205959_at | 2.8733 | 0.0125 | |
| GSE53622 | MMP13 | 4322 | 38014 | 2.7849 | 0.0000 | |
| GSE53624 | MMP13 | 4322 | 38014 | 4.3168 | 0.0000 | |
| GSE63941 | MMP13 | 4322 | 205959_at | 1.5619 | 0.3937 | |
| GSE77861 | MMP13 | 4322 | 205959_at | 0.1697 | 0.3093 | |
| GSE97050 | MMP13 | 4322 | A_33_P3221203 | 1.4724 | 0.1581 | |
| SRP007169 | MMP13 | 4322 | RNAseq | 10.5111 | 0.0000 | |
| SRP008496 | MMP13 | 4322 | RNAseq | 8.9600 | 0.0000 | |
| SRP133303 | MMP13 | 4322 | RNAseq | 8.4951 | 0.0000 | |
| SRP159526 | MMP13 | 4322 | RNAseq | 5.5596 | 0.0000 | |
| SRP219564 | MMP13 | 4322 | RNAseq | 10.1970 | 0.0000 | |
| TCGA | MMP13 | 4322 | RNAseq | 4.2326 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by MMP13 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP13:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP13 | 4322 | 4 | 8 | 18 | |
| GSE20123 | MMP13 | 4322 | 5 | 8 | 17 | |
| GSE43470 | MMP13 | 4322 | 5 | 5 | 33 | |
| GSE46452 | MMP13 | 4322 | 5 | 24 | 30 | |
| GSE47630 | MMP13 | 4322 | 2 | 19 | 19 | |
| GSE54993 | MMP13 | 4322 | 9 | 1 | 60 | |
| GSE54994 | MMP13 | 4322 | 6 | 18 | 29 | |
| GSE60625 | MMP13 | 4322 | 0 | 3 | 8 | |
| GSE74703 | MMP13 | 4322 | 3 | 4 | 29 | |
| GSE74704 | MMP13 | 4322 | 5 | 4 | 11 | |
| TCGA | MMP13 | 4322 | 10 | 44 | 42 |
Total number of gains: 54; Total number of losses: 138; Total Number of normals: 296.
Somatic mutations of MMP13:
Generating mutation plots.
Highly correlated genes for MMP13:
Showing top 20/834 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP13 | MMP10 | 0.720477 | 12 | 0 | 11 |
| MMP13 | SCYL1 | 0.719349 | 3 | 0 | 3 |
| MMP13 | COA4 | 0.692809 | 3 | 0 | 3 |
| MMP13 | INHBA | 0.683765 | 11 | 0 | 11 |
| MMP13 | TBX15 | 0.68078 | 4 | 0 | 3 |
| MMP13 | FBLIM1 | 0.67811 | 7 | 0 | 6 |
| MMP13 | GTF2E2 | 0.67351 | 3 | 0 | 3 |
| MMP13 | ZNF574 | 0.670626 | 3 | 0 | 3 |
| MMP13 | MMP1 | 0.667186 | 13 | 0 | 11 |
| MMP13 | ATAD3A | 0.6613 | 4 | 0 | 4 |
| MMP13 | COL5A2 | 0.656946 | 12 | 0 | 11 |
| MMP13 | SLC24A2 | 0.65652 | 3 | 0 | 3 |
| MMP13 | SNX5 | 0.652349 | 4 | 0 | 3 |
| MMP13 | MRPL14 | 0.651297 | 4 | 0 | 3 |
| MMP13 | GPX8 | 0.647877 | 6 | 0 | 6 |
| MMP13 | CD276 | 0.647179 | 5 | 0 | 4 |
| MMP13 | PLAU | 0.646965 | 13 | 0 | 11 |
| MMP13 | MRGBP | 0.646953 | 9 | 0 | 8 |
| MMP13 | RRP12 | 0.642136 | 3 | 0 | 3 |
| MMP13 | FNDC1 | 0.641162 | 6 | 0 | 5 |
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