| Full name: MORC family CW-type zinc finger 3 | Alias Symbol: ZCW5|NXP2|KIAA0136 | ||
| Type: protein-coding gene | Cytoband: 21q22.12 | ||
| Entrez ID: 23515 | HGNC ID: HGNC:23572 | Ensembl Gene: ENSG00000159256 | OMIM ID: 610078 |
| Drug and gene relationship at DGIdb | |||
Expression of MORC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MORC3 | 23515 | 213000_at | -0.2602 | 0.5431 | |
| GSE20347 | MORC3 | 23515 | 213000_at | -0.4347 | 0.0045 | |
| GSE23400 | MORC3 | 23515 | 213000_at | -0.2687 | 0.0018 | |
| GSE26886 | MORC3 | 23515 | 213000_at | -1.3139 | 0.0000 | |
| GSE29001 | MORC3 | 23515 | 213000_at | -0.3008 | 0.1975 | |
| GSE38129 | MORC3 | 23515 | 213000_at | -0.3449 | 0.0107 | |
| GSE45670 | MORC3 | 23515 | 213000_at | -0.0067 | 0.9745 | |
| GSE53622 | MORC3 | 23515 | 31917 | -0.5265 | 0.0000 | |
| GSE53624 | MORC3 | 23515 | 31917 | -0.6316 | 0.0000 | |
| GSE63941 | MORC3 | 23515 | 213000_at | -0.1056 | 0.7777 | |
| GSE77861 | MORC3 | 23515 | 213000_at | -0.7571 | 0.0180 | |
| GSE97050 | MORC3 | 23515 | A_23_P325501 | -0.2802 | 0.3330 | |
| SRP007169 | MORC3 | 23515 | RNAseq | -1.7589 | 0.0000 | |
| SRP008496 | MORC3 | 23515 | RNAseq | -1.2882 | 0.0000 | |
| SRP064894 | MORC3 | 23515 | RNAseq | -0.7061 | 0.0247 | |
| SRP133303 | MORC3 | 23515 | RNAseq | -0.4167 | 0.0100 | |
| SRP159526 | MORC3 | 23515 | RNAseq | -0.9659 | 0.0216 | |
| SRP193095 | MORC3 | 23515 | RNAseq | -0.6503 | 0.0000 | |
| SRP219564 | MORC3 | 23515 | RNAseq | -0.9878 | 0.0206 | |
| TCGA | MORC3 | 23515 | RNAseq | 0.0088 | 0.8611 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by MORC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MORC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MORC3 | 23515 | 2 | 8 | 20 | |
| GSE20123 | MORC3 | 23515 | 2 | 9 | 19 | |
| GSE43470 | MORC3 | 23515 | 1 | 11 | 31 | |
| GSE46452 | MORC3 | 23515 | 1 | 21 | 37 | |
| GSE47630 | MORC3 | 23515 | 6 | 17 | 17 | |
| GSE54993 | MORC3 | 23515 | 8 | 1 | 61 | |
| GSE54994 | MORC3 | 23515 | 2 | 9 | 42 | |
| GSE60625 | MORC3 | 23515 | 0 | 0 | 11 | |
| GSE74703 | MORC3 | 23515 | 1 | 8 | 27 | |
| GSE74704 | MORC3 | 23515 | 1 | 5 | 14 | |
| TCGA | MORC3 | 23515 | 9 | 39 | 48 |
Total number of gains: 33; Total number of losses: 128; Total Number of normals: 327.
Somatic mutations of MORC3:
Generating mutation plots.
Highly correlated genes for MORC3:
Showing top 20/1380 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MORC3 | ABHD14B | 0.788347 | 3 | 0 | 3 |
| MORC3 | ZNF92 | 0.78719 | 3 | 0 | 3 |
| MORC3 | PRPF38A | 0.784051 | 3 | 0 | 3 |
| MORC3 | RBM20 | 0.767408 | 3 | 0 | 3 |
| MORC3 | IFT46 | 0.756824 | 3 | 0 | 3 |
| MORC3 | WBP2 | 0.743227 | 3 | 0 | 3 |
| MORC3 | COG5 | 0.73622 | 3 | 0 | 3 |
| MORC3 | ZNF823 | 0.734724 | 6 | 0 | 5 |
| MORC3 | MNS1 | 0.734528 | 3 | 0 | 3 |
| MORC3 | ZNF70 | 0.734182 | 3 | 0 | 3 |
| MORC3 | TRIM6 | 0.729319 | 7 | 0 | 7 |
| MORC3 | MAGI3 | 0.726585 | 5 | 0 | 4 |
| MORC3 | ZNF514 | 0.724369 | 3 | 0 | 3 |
| MORC3 | CRBN | 0.718755 | 4 | 0 | 4 |
| MORC3 | PITHD1 | 0.714865 | 6 | 0 | 6 |
| MORC3 | MRPL46 | 0.711273 | 4 | 0 | 3 |
| MORC3 | CLIP1 | 0.711143 | 11 | 0 | 11 |
| MORC3 | TAB3 | 0.708335 | 7 | 0 | 7 |
| MORC3 | EXOC4 | 0.703047 | 4 | 0 | 4 |
| MORC3 | FCHO2 | 0.699893 | 7 | 0 | 6 |
For details and further investigation, click here
