| Full name: mannose-P-dolichol utilization defect 1 | Alias Symbol: SL15|Lec35|PQLC5|CDGIf|SLC66A5 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 9526 | HGNC ID: HGNC:7207 | Ensembl Gene: ENSG00000129255 | OMIM ID: 604041 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MPDU1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MPDU1 | 9526 | 209208_at | 0.0658 | 0.9307 | |
| GSE20347 | MPDU1 | 9526 | 209208_at | -0.1395 | 0.5491 | |
| GSE23400 | MPDU1 | 9526 | 209208_at | 0.0853 | 0.1661 | |
| GSE26886 | MPDU1 | 9526 | 209208_at | -0.8023 | 0.0039 | |
| GSE29001 | MPDU1 | 9526 | 209208_at | -0.1857 | 0.4729 | |
| GSE38129 | MPDU1 | 9526 | 209208_at | 0.2493 | 0.1905 | |
| GSE45670 | MPDU1 | 9526 | 209208_at | 0.1047 | 0.5641 | |
| GSE53622 | MPDU1 | 9526 | 3997 | 0.1169 | 0.3309 | |
| GSE53624 | MPDU1 | 9526 | 47956 | 0.2656 | 0.0000 | |
| GSE63941 | MPDU1 | 9526 | 209208_at | 0.8554 | 0.0711 | |
| GSE77861 | MPDU1 | 9526 | 209208_at | 0.1204 | 0.5281 | |
| GSE97050 | MPDU1 | 9526 | A_24_P198844 | 0.5754 | 0.1753 | |
| SRP007169 | MPDU1 | 9526 | RNAseq | -0.6591 | 0.1339 | |
| SRP008496 | MPDU1 | 9526 | RNAseq | -0.6032 | 0.0173 | |
| SRP064894 | MPDU1 | 9526 | RNAseq | 0.1044 | 0.7152 | |
| SRP133303 | MPDU1 | 9526 | RNAseq | -0.0314 | 0.8561 | |
| SRP159526 | MPDU1 | 9526 | RNAseq | 0.1144 | 0.5150 | |
| SRP193095 | MPDU1 | 9526 | RNAseq | -0.2157 | 0.1394 | |
| SRP219564 | MPDU1 | 9526 | RNAseq | 0.6220 | 0.1769 | |
| TCGA | MPDU1 | 9526 | RNAseq | -0.0593 | 0.3718 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MPDU1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MPDU1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MPDU1 | 9526 | 4 | 2 | 24 | |
| GSE20123 | MPDU1 | 9526 | 4 | 3 | 23 | |
| GSE43470 | MPDU1 | 9526 | 1 | 5 | 37 | |
| GSE46452 | MPDU1 | 9526 | 34 | 1 | 24 | |
| GSE47630 | MPDU1 | 9526 | 7 | 1 | 32 | |
| GSE54993 | MPDU1 | 9526 | 4 | 3 | 63 | |
| GSE54994 | MPDU1 | 9526 | 5 | 8 | 40 | |
| GSE60625 | MPDU1 | 9526 | 4 | 0 | 7 | |
| GSE74703 | MPDU1 | 9526 | 1 | 2 | 33 | |
| GSE74704 | MPDU1 | 9526 | 2 | 1 | 17 | |
| TCGA | MPDU1 | 9526 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 47; Total Number of normals: 358.
Somatic mutations of MPDU1:
Generating mutation plots.
Highly correlated genes for MPDU1:
Showing top 20/46 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MPDU1 | AGPAT2 | 0.693471 | 3 | 0 | 3 |
| MPDU1 | CLECL1 | 0.676706 | 3 | 0 | 3 |
| MPDU1 | TBC1D10C | 0.649199 | 3 | 0 | 3 |
| MPDU1 | MAPK13 | 0.633509 | 4 | 0 | 3 |
| MPDU1 | CPNE5 | 0.632463 | 3 | 0 | 3 |
| MPDU1 | ZNF620 | 0.623054 | 3 | 0 | 3 |
| MPDU1 | GPATCH3 | 0.618309 | 3 | 0 | 3 |
| MPDU1 | ERBB2 | 0.614555 | 3 | 0 | 3 |
| MPDU1 | STXBP2 | 0.60882 | 6 | 0 | 4 |
| MPDU1 | PHLDB3 | 0.59263 | 3 | 0 | 3 |
| MPDU1 | SLC35B1 | 0.587302 | 6 | 0 | 5 |
| MPDU1 | MAL2 | 0.583652 | 5 | 0 | 3 |
| MPDU1 | EMC6 | 0.581088 | 6 | 0 | 5 |
| MPDU1 | ZDHHC13 | 0.578554 | 4 | 0 | 3 |
| MPDU1 | TM9SF2 | 0.574648 | 5 | 0 | 4 |
| MPDU1 | SLC25A39 | 0.566322 | 4 | 0 | 3 |
| MPDU1 | PPP1CA | 0.560703 | 8 | 0 | 5 |
| MPDU1 | ALDH16A1 | 0.560135 | 5 | 0 | 3 |
| MPDU1 | NCF4 | 0.557382 | 5 | 0 | 3 |
| MPDU1 | TRIM16 | 0.550342 | 6 | 0 | 4 |
For details and further investigation, click here
