| Full name: dynein light chain LC8-type 1 | Alias Symbol: hdlc1|DLC1|PIN|LC8|DLC8 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 8655 | HGNC ID: HGNC:15476 | Ensembl Gene: ENSG00000088986 | OMIM ID: 601562 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of DYNLL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DYNLL1 | 8655 | 200703_at | -0.2825 | 0.4619 | |
| GSE20347 | DYNLL1 | 8655 | 200703_at | -0.6177 | 0.0000 | |
| GSE23400 | DYNLL1 | 8655 | 200703_at | -0.3271 | 0.0000 | |
| GSE26886 | DYNLL1 | 8655 | 200703_at | -0.5483 | 0.0004 | |
| GSE29001 | DYNLL1 | 8655 | 200703_at | -0.5800 | 0.0294 | |
| GSE38129 | DYNLL1 | 8655 | 200703_at | -0.3352 | 0.0029 | |
| GSE45670 | DYNLL1 | 8655 | 200703_at | 0.0072 | 0.9566 | |
| GSE53622 | DYNLL1 | 8655 | 19718 | -0.2936 | 0.0003 | |
| GSE53624 | DYNLL1 | 8655 | 19718 | -0.2573 | 0.0000 | |
| GSE63941 | DYNLL1 | 8655 | 200703_at | 0.4320 | 0.0111 | |
| GSE77861 | DYNLL1 | 8655 | 200703_at | -0.3985 | 0.0486 | |
| GSE97050 | DYNLL1 | 8655 | A_24_P124672 | 0.0300 | 0.9113 | |
| SRP007169 | DYNLL1 | 8655 | RNAseq | -1.7339 | 0.0000 | |
| SRP008496 | DYNLL1 | 8655 | RNAseq | -1.5693 | 0.0000 | |
| SRP064894 | DYNLL1 | 8655 | RNAseq | -0.8408 | 0.0002 | |
| SRP133303 | DYNLL1 | 8655 | RNAseq | -0.6812 | 0.0000 | |
| SRP159526 | DYNLL1 | 8655 | RNAseq | -0.9164 | 0.0006 | |
| SRP193095 | DYNLL1 | 8655 | RNAseq | -1.2873 | 0.0000 | |
| SRP219564 | DYNLL1 | 8655 | RNAseq | -1.1791 | 0.0011 | |
| TCGA | DYNLL1 | 8655 | RNAseq | 0.1104 | 0.0425 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by DYNLL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DYNLL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DYNLL1 | 8655 | 6 | 2 | 22 | |
| GSE20123 | DYNLL1 | 8655 | 6 | 2 | 22 | |
| GSE43470 | DYNLL1 | 8655 | 2 | 2 | 39 | |
| GSE46452 | DYNLL1 | 8655 | 9 | 1 | 49 | |
| GSE47630 | DYNLL1 | 8655 | 9 | 3 | 28 | |
| GSE54993 | DYNLL1 | 8655 | 0 | 5 | 65 | |
| GSE54994 | DYNLL1 | 8655 | 7 | 6 | 40 | |
| GSE60625 | DYNLL1 | 8655 | 0 | 0 | 11 | |
| GSE74703 | DYNLL1 | 8655 | 2 | 1 | 33 | |
| GSE74704 | DYNLL1 | 8655 | 3 | 2 | 15 | |
| TCGA | DYNLL1 | 8655 | 20 | 11 | 65 |
Total number of gains: 64; Total number of losses: 35; Total Number of normals: 389.
Somatic mutations of DYNLL1:
Generating mutation plots.
Highly correlated genes for DYNLL1:
Showing top 20/816 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DYNLL1 | S100A16 | 0.738835 | 8 | 0 | 8 |
| DYNLL1 | ORMDL2 | 0.725209 | 9 | 0 | 8 |
| DYNLL1 | RAB11A | 0.706415 | 10 | 0 | 8 |
| DYNLL1 | PPP4R1 | 0.68796 | 8 | 0 | 8 |
| DYNLL1 | MRPL23 | 0.684114 | 5 | 0 | 5 |
| DYNLL1 | IL1RN | 0.683499 | 11 | 0 | 10 |
| DYNLL1 | TMED3 | 0.681556 | 10 | 0 | 10 |
| DYNLL1 | MFSD5 | 0.681434 | 11 | 0 | 8 |
| DYNLL1 | RAET1E | 0.677112 | 7 | 0 | 6 |
| DYNLL1 | NAGK | 0.676404 | 10 | 0 | 9 |
| DYNLL1 | GBP6 | 0.674 | 4 | 0 | 4 |
| DYNLL1 | ARPC3 | 0.673888 | 12 | 0 | 10 |
| DYNLL1 | DSC2 | 0.673065 | 12 | 0 | 11 |
| DYNLL1 | ELMO2 | 0.670234 | 9 | 0 | 9 |
| DYNLL1 | EVPL | 0.670159 | 11 | 0 | 9 |
| DYNLL1 | CLIC3 | 0.667865 | 10 | 0 | 9 |
| DYNLL1 | ACPP | 0.667853 | 11 | 0 | 10 |
| DYNLL1 | S100A14 | 0.665703 | 12 | 0 | 10 |
| DYNLL1 | CNFN | 0.664594 | 8 | 0 | 7 |
| DYNLL1 | SLCO2B1 | 0.66448 | 3 | 0 | 3 |
For details and further investigation, click here
