| Full name: TNF receptor superfamily member 18 | Alias Symbol: AITR|GITR|CD357 | ||
| Type: protein-coding gene | Cytoband: 1p36.33 | ||
| Entrez ID: 8784 | HGNC ID: HGNC:11914 | Ensembl Gene: ENSG00000186891 | OMIM ID: 603905 |
| Drug and gene relationship at DGIdb | |||
Expression of TNFRSF18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFRSF18 | 8784 | 223851_s_at | 0.7370 | 0.2038 | |
| GSE26886 | TNFRSF18 | 8784 | 224553_s_at | 1.4990 | 0.0009 | |
| GSE45670 | TNFRSF18 | 8784 | 223851_s_at | 0.8737 | 0.0022 | |
| GSE53622 | TNFRSF18 | 8784 | 77874 | 2.1491 | 0.0000 | |
| GSE53624 | TNFRSF18 | 8784 | 77874 | 2.2732 | 0.0000 | |
| GSE63941 | TNFRSF18 | 8784 | 223851_s_at | 0.4829 | 0.4453 | |
| GSE77861 | TNFRSF18 | 8784 | 223851_s_at | 0.4424 | 0.1036 | |
| SRP007169 | TNFRSF18 | 8784 | RNAseq | 2.5370 | 0.0005 | |
| SRP064894 | TNFRSF18 | 8784 | RNAseq | 3.2415 | 0.0000 | |
| SRP133303 | TNFRSF18 | 8784 | RNAseq | 1.8612 | 0.0000 | |
| SRP159526 | TNFRSF18 | 8784 | RNAseq | 2.9874 | 0.0000 | |
| SRP193095 | TNFRSF18 | 8784 | RNAseq | 2.1199 | 0.0000 | |
| SRP219564 | TNFRSF18 | 8784 | RNAseq | 1.1006 | 0.0600 | |
| TCGA | TNFRSF18 | 8784 | RNAseq | 1.9973 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by TNFRSF18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFRSF18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFRSF18 | 8784 | 3 | 7 | 20 | |
| GSE20123 | TNFRSF18 | 8784 | 3 | 6 | 21 | |
| GSE43470 | TNFRSF18 | 8784 | 3 | 5 | 35 | |
| GSE46452 | TNFRSF18 | 8784 | 7 | 1 | 51 | |
| GSE47630 | TNFRSF18 | 8784 | 8 | 4 | 28 | |
| GSE54993 | TNFRSF18 | 8784 | 2 | 2 | 66 | |
| GSE54994 | TNFRSF18 | 8784 | 15 | 2 | 36 | |
| GSE60625 | TNFRSF18 | 8784 | 0 | 0 | 11 | |
| GSE74703 | TNFRSF18 | 8784 | 3 | 3 | 30 | |
| GSE74704 | TNFRSF18 | 8784 | 3 | 0 | 17 | |
| TCGA | TNFRSF18 | 8784 | 14 | 20 | 62 |
Total number of gains: 61; Total number of losses: 50; Total Number of normals: 377.
Somatic mutations of TNFRSF18:
Generating mutation plots.
Highly correlated genes for TNFRSF18:
Showing top 20/1058 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFRSF18 | PIK3CD | 0.737908 | 3 | 0 | 3 |
| TNFRSF18 | NEIL2 | 0.731489 | 3 | 0 | 3 |
| TNFRSF18 | ENPEP | 0.719936 | 3 | 0 | 3 |
| TNFRSF18 | PSMB3 | 0.69439 | 5 | 0 | 5 |
| TNFRSF18 | ADAMTS12 | 0.691453 | 5 | 0 | 5 |
| TNFRSF18 | LOXL2 | 0.687892 | 5 | 0 | 4 |
| TNFRSF18 | RAB15 | 0.687468 | 5 | 0 | 5 |
| TNFRSF18 | P2RY6 | 0.684226 | 3 | 0 | 3 |
| TNFRSF18 | TTYH3 | 0.683491 | 5 | 0 | 4 |
| TNFRSF18 | PLA2G7 | 0.679314 | 4 | 0 | 3 |
| TNFRSF18 | KNSTRN | 0.678645 | 5 | 0 | 4 |
| TNFRSF18 | SYT1 | 0.677305 | 3 | 0 | 3 |
| TNFRSF18 | C12orf75 | 0.67684 | 5 | 0 | 4 |
| TNFRSF18 | BID | 0.676661 | 6 | 0 | 5 |
| TNFRSF18 | CHEK1 | 0.676261 | 4 | 0 | 3 |
| TNFRSF18 | BCL2A1 | 0.676057 | 4 | 0 | 4 |
| TNFRSF18 | RHBDD2 | 0.673607 | 5 | 0 | 5 |
| TNFRSF18 | MMP11 | 0.673503 | 4 | 0 | 4 |
| TNFRSF18 | ADAMTS2 | 0.672596 | 4 | 0 | 4 |
| TNFRSF18 | FANCB | 0.672503 | 3 | 0 | 3 |
For details and further investigation, click here
