| Full name: metallothionein 1H | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16q13 | ||
| Entrez ID: 4496 | HGNC ID: HGNC:7400 | Ensembl Gene: ENSG00000205358 | OMIM ID: 156354 |
| Drug and gene relationship at DGIdb | |||
Expression of MT1H:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MT1H | 4496 | 206461_x_at | -0.0657 | 0.9455 | |
| GSE20347 | MT1H | 4496 | 206461_x_at | 0.0082 | 0.9786 | |
| GSE23400 | MT1H | 4496 | 206461_x_at | -0.3683 | 0.0064 | |
| GSE26886 | MT1H | 4496 | 206461_x_at | -0.3095 | 0.6180 | |
| GSE29001 | MT1H | 4496 | 206461_x_at | -0.5007 | 0.0827 | |
| GSE38129 | MT1H | 4496 | 206461_x_at | -0.1077 | 0.7115 | |
| GSE45670 | MT1H | 4496 | 206461_x_at | -0.6930 | 0.0326 | |
| GSE53622 | MT1H | 4496 | 79040 | -1.8570 | 0.0000 | |
| GSE53624 | MT1H | 4496 | 79040 | -1.4694 | 0.0000 | |
| GSE63941 | MT1H | 4496 | 206461_x_at | -1.8155 | 0.1466 | |
| GSE77861 | MT1H | 4496 | 206461_x_at | -0.8193 | 0.1055 | |
| GSE97050 | MT1H | 4496 | A_33_P3315314 | -0.6368 | 0.2540 | |
| SRP064894 | MT1H | 4496 | RNAseq | -3.6844 | 0.0000 | |
| SRP133303 | MT1H | 4496 | RNAseq | -3.1835 | 0.0000 | |
| SRP159526 | MT1H | 4496 | RNAseq | -3.6430 | 0.0001 | |
| TCGA | MT1H | 4496 | RNAseq | -2.0096 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by MT1H expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MT1H:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MT1H | 4496 | 5 | 0 | 25 | |
| GSE20123 | MT1H | 4496 | 5 | 1 | 24 | |
| GSE43470 | MT1H | 4496 | 2 | 7 | 34 | |
| GSE46452 | MT1H | 4496 | 38 | 1 | 20 | |
| GSE47630 | MT1H | 4496 | 10 | 8 | 22 | |
| GSE54993 | MT1H | 4496 | 2 | 4 | 64 | |
| GSE54994 | MT1H | 4496 | 7 | 10 | 36 | |
| GSE60625 | MT1H | 4496 | 4 | 0 | 7 | |
| GSE74703 | MT1H | 4496 | 2 | 4 | 30 | |
| GSE74704 | MT1H | 4496 | 4 | 0 | 16 | |
| TCGA | MT1H | 4496 | 25 | 13 | 58 |
Total number of gains: 104; Total number of losses: 48; Total Number of normals: 336.
Somatic mutations of MT1H:
Generating mutation plots.
Highly correlated genes for MT1H:
Showing top 20/82 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MT1H | MT1HL1 | 0.953235 | 11 | 0 | 11 |
| MT1H | MT1G | 0.907491 | 11 | 0 | 10 |
| MT1H | MT1X | 0.862067 | 13 | 0 | 12 |
| MT1H | MT1F | 0.833236 | 12 | 0 | 10 |
| MT1H | MT2A | 0.825579 | 12 | 0 | 10 |
| MT1H | MT1E | 0.746276 | 13 | 0 | 12 |
| MT1H | LEPROT | 0.69074 | 4 | 0 | 4 |
| MT1H | MT1B | 0.664267 | 3 | 0 | 3 |
| MT1H | SPATA3-AS1 | 0.642266 | 3 | 0 | 3 |
| MT1H | MT1M | 0.627199 | 12 | 0 | 10 |
| MT1H | KIFC3 | 0.612131 | 3 | 0 | 3 |
| MT1H | TMEM50A | 0.59672 | 4 | 0 | 3 |
| MT1H | FAM187B | 0.593609 | 4 | 0 | 3 |
| MT1H | STX4 | 0.591781 | 3 | 0 | 3 |
| MT1H | GLCE | 0.582352 | 3 | 0 | 3 |
| MT1H | FIGN | 0.576215 | 3 | 0 | 3 |
| MT1H | HSPA2 | 0.575978 | 6 | 0 | 4 |
| MT1H | VAMP3 | 0.572387 | 5 | 0 | 4 |
| MT1H | SOCS3 | 0.571661 | 4 | 0 | 3 |
| MT1H | ANKRD13C | 0.570797 | 3 | 0 | 3 |
For details and further investigation, click here
