| Full name: metallothionein 1E | Alias Symbol: MTD | ||
| Type: protein-coding gene | Cytoband: 16q13 | ||
| Entrez ID: 4493 | HGNC ID: HGNC:7397 | Ensembl Gene: ENSG00000169715 | OMIM ID: 156351 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MT1E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MT1E | 4493 | 212859_x_at | -0.2320 | 0.7977 | |
| GSE20347 | MT1E | 4493 | 212859_x_at | -0.3322 | 0.4326 | |
| GSE23400 | MT1E | 4493 | 212859_x_at | -0.5553 | 0.0013 | |
| GSE26886 | MT1E | 4493 | 212859_x_at | 0.2717 | 0.6874 | |
| GSE29001 | MT1E | 4493 | 212859_x_at | -0.4592 | 0.1738 | |
| GSE38129 | MT1E | 4493 | 212859_x_at | -0.6280 | 0.0591 | |
| GSE45670 | MT1E | 4493 | 212859_x_at | -0.7709 | 0.0454 | |
| GSE53622 | MT1E | 4493 | 149297 | -0.8028 | 0.0000 | |
| GSE53624 | MT1E | 4493 | 149297 | -0.3653 | 0.0006 | |
| GSE63941 | MT1E | 4493 | 212859_x_at | -1.8865 | 0.2373 | |
| GSE77861 | MT1E | 4493 | 212859_x_at | -0.9674 | 0.1798 | |
| GSE97050 | MT1E | A_21_P0000671 | -0.6945 | 0.1399 | ||
| SRP007169 | MT1E | 4493 | RNAseq | -2.5100 | 0.0868 | |
| SRP008496 | MT1E | 4493 | RNAseq | -2.3967 | 0.0090 | |
| SRP064894 | MT1E | 4493 | RNAseq | -0.5543 | 0.2371 | |
| SRP133303 | MT1E | 4493 | RNAseq | -0.5601 | 0.2081 | |
| SRP159526 | MT1E | 4493 | RNAseq | -0.2551 | 0.6952 | |
| SRP193095 | MT1E | 4493 | RNAseq | -1.2820 | 0.0004 | |
| SRP219564 | MT1E | 4493 | RNAseq | -0.9892 | 0.1490 | |
| TCGA | MT1E | 4493 | RNAseq | -0.6095 | 0.0022 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by MT1E expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MT1E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MT1E | 4493 | 5 | 0 | 25 | |
| GSE20123 | MT1E | 4493 | 5 | 1 | 24 | |
| GSE43470 | MT1E | 4493 | 2 | 7 | 34 | |
| GSE46452 | MT1E | 4493 | 38 | 1 | 20 | |
| GSE47630 | MT1E | 4493 | 10 | 8 | 22 | |
| GSE54993 | MT1E | 4493 | 2 | 4 | 64 | |
| GSE54994 | MT1E | 4493 | 7 | 10 | 36 | |
| GSE60625 | MT1E | 4493 | 4 | 0 | 7 | |
| GSE74703 | MT1E | 4493 | 2 | 4 | 30 | |
| GSE74704 | MT1E | 4493 | 4 | 0 | 16 | |
| TCGA | MT1E | 4493 | 25 | 12 | 59 |
Total number of gains: 104; Total number of losses: 47; Total Number of normals: 337.
Somatic mutations of MT1E:
Generating mutation plots.
Highly correlated genes for MT1E:
Showing top 20/54 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MT1E | MT1B | 0.854346 | 3 | 0 | 3 |
| MT1E | MT1H | 0.746276 | 13 | 0 | 12 |
| MT1E | MT1G | 0.725432 | 10 | 0 | 9 |
| MT1E | MT1HL1 | 0.722735 | 11 | 0 | 11 |
| MT1E | MT1F | 0.699544 | 12 | 0 | 10 |
| MT1E | MT1M | 0.688695 | 12 | 0 | 11 |
| MT1E | MT1X | 0.678666 | 13 | 0 | 11 |
| MT1E | BCAS2 | 0.660456 | 3 | 0 | 3 |
| MT1E | SNCA | 0.66036 | 4 | 0 | 4 |
| MT1E | AGL | 0.658637 | 3 | 0 | 3 |
| MT1E | MT2A | 0.655806 | 13 | 0 | 10 |
| MT1E | MT1A | 0.651948 | 4 | 0 | 3 |
| MT1E | VPS37A | 0.648307 | 3 | 0 | 3 |
| MT1E | WDR73 | 0.647215 | 3 | 0 | 3 |
| MT1E | KCTD9 | 0.639359 | 4 | 0 | 3 |
| MT1E | HOOK3 | 0.618567 | 3 | 0 | 3 |
| MT1E | CDC42EP3 | 0.611727 | 3 | 0 | 3 |
| MT1E | C4orf36 | 0.611608 | 3 | 0 | 3 |
| MT1E | ATOX1 | 0.609328 | 3 | 0 | 3 |
| MT1E | GPSM2 | 0.593835 | 4 | 0 | 3 |
For details and further investigation, click here
