| Full name: metallothionein 2A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16q13 | ||
| Entrez ID: 4502 | HGNC ID: HGNC:7406 | Ensembl Gene: ENSG00000125148 | OMIM ID: 156360 |
| Drug and gene relationship at DGIdb | |||
Expression of MT2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MT2A | 4502 | 212185_x_at | 0.1750 | 0.8436 | |
| GSE20347 | MT2A | 4502 | 212185_x_at | 0.3520 | 0.2177 | |
| GSE23400 | MT2A | 4502 | 212185_x_at | -0.0605 | 0.6795 | |
| GSE26886 | MT2A | 4502 | 212185_x_at | 0.1803 | 0.7795 | |
| GSE29001 | MT2A | 4502 | 212185_x_at | -0.0714 | 0.8646 | |
| GSE38129 | MT2A | 4502 | 212185_x_at | 0.1323 | 0.6562 | |
| GSE45670 | MT2A | 4502 | 212185_x_at | -0.4320 | 0.2656 | |
| GSE53622 | MT2A | 4502 | 163358 | -0.0212 | 0.8989 | |
| GSE53624 | MT2A | 4502 | 163358 | 0.3823 | 0.0001 | |
| GSE63941 | MT2A | 4502 | 212185_x_at | -2.0311 | 0.1478 | |
| GSE77861 | MT2A | 4502 | 212185_x_at | -0.3862 | 0.4502 | |
| GSE97050 | MT2A | 4502 | A_23_P106844 | -0.2364 | 0.5932 | |
| SRP007169 | MT2A | 4502 | RNAseq | -2.5319 | 0.0084 | |
| SRP008496 | MT2A | 4502 | RNAseq | -2.1570 | 0.0091 | |
| SRP064894 | MT2A | 4502 | RNAseq | 0.6928 | 0.0817 | |
| SRP133303 | MT2A | 4502 | RNAseq | 0.7891 | 0.1228 | |
| SRP159526 | MT2A | 4502 | RNAseq | 0.2919 | 0.6259 | |
| SRP193095 | MT2A | 4502 | RNAseq | -0.0537 | 0.8737 | |
| SRP219564 | MT2A | 4502 | RNAseq | 1.3313 | 0.0375 | |
| TCGA | MT2A | 4502 | RNAseq | -0.2142 | 0.0629 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by MT2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MT2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MT2A | 4502 | 5 | 0 | 25 | |
| GSE20123 | MT2A | 4502 | 5 | 1 | 24 | |
| GSE43470 | MT2A | 4502 | 2 | 7 | 34 | |
| GSE46452 | MT2A | 4502 | 38 | 1 | 20 | |
| GSE47630 | MT2A | 4502 | 10 | 8 | 22 | |
| GSE54993 | MT2A | 4502 | 2 | 4 | 64 | |
| GSE54994 | MT2A | 4502 | 7 | 10 | 36 | |
| GSE60625 | MT2A | 4502 | 4 | 0 | 7 | |
| GSE74703 | MT2A | 4502 | 2 | 4 | 30 | |
| GSE74704 | MT2A | 4502 | 4 | 0 | 16 | |
| TCGA | MT2A | 4502 | 25 | 12 | 59 |
Total number of gains: 104; Total number of losses: 47; Total Number of normals: 337.
Somatic mutations of MT2A:
Generating mutation plots.
Highly correlated genes for MT2A:
Showing top 20/54 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MT2A | MT1G | 0.838757 | 10 | 0 | 9 |
| MT2A | MT1HL1 | 0.834743 | 11 | 0 | 9 |
| MT2A | MT1H | 0.825579 | 12 | 0 | 10 |
| MT2A | MT1X | 0.815936 | 13 | 0 | 11 |
| MT2A | MT1F | 0.814396 | 12 | 0 | 11 |
| MT2A | MT1B | 0.77364 | 3 | 0 | 3 |
| MT2A | MT1E | 0.655806 | 13 | 0 | 10 |
| MT2A | ELK3 | 0.607403 | 3 | 0 | 3 |
| MT2A | NUDCD2 | 0.584937 | 3 | 0 | 3 |
| MT2A | PEAR1 | 0.58106 | 4 | 0 | 3 |
| MT2A | DMRTA1 | 0.579785 | 4 | 0 | 3 |
| MT2A | KCNC4 | 0.574783 | 3 | 0 | 3 |
| MT2A | ST6GALNAC5 | 0.569764 | 4 | 0 | 3 |
| MT2A | ITGB1BP1 | 0.556542 | 4 | 0 | 3 |
| MT2A | KIFC3 | 0.554857 | 6 | 0 | 4 |
| MT2A | MICA | 0.554053 | 4 | 0 | 4 |
| MT2A | TNFRSF8 | 0.553754 | 4 | 0 | 3 |
| MT2A | SSR3 | 0.550574 | 5 | 0 | 3 |
| MT2A | HTRA2 | 0.550339 | 3 | 0 | 3 |
| MT2A | SMIM3 | 0.546899 | 5 | 0 | 3 |
For details and further investigation, click here
