| Full name: NFKB inhibitor interacting Ras like 2 | Alias Symbol: KBRAS2|DKFZP434N1526|kappaB-Ras2 | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 28511 | HGNC ID: HGNC:17898 | Ensembl Gene: ENSG00000168256 | OMIM ID: 604497 |
| Drug and gene relationship at DGIdb | |||
Expression of NKIRAS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NKIRAS2 | 28511 | 218240_at | 0.0417 | 0.9176 | |
| GSE20347 | NKIRAS2 | 28511 | 218240_at | -0.2976 | 0.0005 | |
| GSE23400 | NKIRAS2 | 28511 | 218240_at | -0.0559 | 0.2002 | |
| GSE26886 | NKIRAS2 | 28511 | 222105_s_at | 0.1675 | 0.2951 | |
| GSE29001 | NKIRAS2 | 28511 | 218240_at | -0.3023 | 0.2289 | |
| GSE38129 | NKIRAS2 | 28511 | 218240_at | -0.1481 | 0.1264 | |
| GSE45670 | NKIRAS2 | 28511 | 218240_at | 0.1673 | 0.1343 | |
| GSE53622 | NKIRAS2 | 28511 | 32432 | 0.2171 | 0.0000 | |
| GSE53624 | NKIRAS2 | 28511 | 32432 | -1.4768 | 0.0000 | |
| GSE63941 | NKIRAS2 | 28511 | 218240_at | 0.0594 | 0.8556 | |
| GSE77861 | NKIRAS2 | 28511 | 218240_at | 0.1714 | 0.4015 | |
| GSE97050 | NKIRAS2 | 28511 | A_23_P10135 | 0.1407 | 0.4621 | |
| SRP007169 | NKIRAS2 | 28511 | RNAseq | -0.7387 | 0.0174 | |
| SRP008496 | NKIRAS2 | 28511 | RNAseq | -0.8098 | 0.0000 | |
| SRP064894 | NKIRAS2 | 28511 | RNAseq | 0.0933 | 0.4203 | |
| SRP133303 | NKIRAS2 | 28511 | RNAseq | 0.1276 | 0.3927 | |
| SRP159526 | NKIRAS2 | 28511 | RNAseq | -0.0724 | 0.6923 | |
| SRP193095 | NKIRAS2 | 28511 | RNAseq | -0.0862 | 0.4765 | |
| SRP219564 | NKIRAS2 | 28511 | RNAseq | -0.4494 | 0.0606 | |
| TCGA | NKIRAS2 | 28511 | RNAseq | 0.1560 | 0.0013 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NKIRAS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NKIRAS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NKIRAS2 | 28511 | 6 | 2 | 22 | |
| GSE20123 | NKIRAS2 | 28511 | 6 | 2 | 22 | |
| GSE43470 | NKIRAS2 | 28511 | 1 | 2 | 40 | |
| GSE46452 | NKIRAS2 | 28511 | 34 | 0 | 25 | |
| GSE47630 | NKIRAS2 | 28511 | 8 | 1 | 31 | |
| GSE54993 | NKIRAS2 | 28511 | 3 | 4 | 63 | |
| GSE54994 | NKIRAS2 | 28511 | 8 | 5 | 40 | |
| GSE60625 | NKIRAS2 | 28511 | 4 | 0 | 7 | |
| GSE74703 | NKIRAS2 | 28511 | 1 | 1 | 34 | |
| GSE74704 | NKIRAS2 | 28511 | 4 | 1 | 15 | |
| TCGA | NKIRAS2 | 28511 | 23 | 6 | 67 |
Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.
Somatic mutations of NKIRAS2:
Generating mutation plots.
Highly correlated genes for NKIRAS2:
Showing top 20/156 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NKIRAS2 | NFAM1 | 0.694375 | 3 | 0 | 3 |
| NKIRAS2 | NDUFA13 | 0.684766 | 4 | 0 | 4 |
| NKIRAS2 | ILKAP | 0.681202 | 3 | 0 | 3 |
| NKIRAS2 | NOTCH2 | 0.666026 | 4 | 0 | 3 |
| NKIRAS2 | KRT18 | 0.659121 | 3 | 0 | 3 |
| NKIRAS2 | SURF1 | 0.655105 | 3 | 0 | 3 |
| NKIRAS2 | TMCC1 | 0.650506 | 3 | 0 | 3 |
| NKIRAS2 | TBCD | 0.64373 | 5 | 0 | 3 |
| NKIRAS2 | DLG2 | 0.637569 | 4 | 0 | 3 |
| NKIRAS2 | ELFN1 | 0.636426 | 3 | 0 | 3 |
| NKIRAS2 | FBXO3 | 0.634145 | 5 | 0 | 4 |
| NKIRAS2 | AKT1S1 | 0.631707 | 3 | 0 | 3 |
| NKIRAS2 | ULK1 | 0.630677 | 3 | 0 | 3 |
| NKIRAS2 | RNF10 | 0.630485 | 4 | 0 | 4 |
| NKIRAS2 | COASY | 0.628011 | 6 | 0 | 4 |
| NKIRAS2 | COX5B | 0.627582 | 4 | 0 | 3 |
| NKIRAS2 | TNFAIP1 | 0.626979 | 3 | 0 | 3 |
| NKIRAS2 | PLXNB2 | 0.619977 | 7 | 0 | 5 |
| NKIRAS2 | CDK9 | 0.618989 | 4 | 0 | 4 |
| NKIRAS2 | KLF16 | 0.614078 | 4 | 0 | 4 |
For details and further investigation, click here
