| Full name: notum, palmitoleoyl-protein carboxylesterase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 147111 | HGNC ID: HGNC:27106 | Ensembl Gene: ENSG00000185269 | OMIM ID: 609847 |
| Drug and gene relationship at DGIdb | |||
NOTUM involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of NOTUM:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NOTUM | 147111 | 228649_at | -0.0076 | 0.9826 | |
| GSE26886 | NOTUM | 147111 | 228649_at | 0.2910 | 0.0144 | |
| GSE45670 | NOTUM | 147111 | 228649_at | -0.1069 | 0.2901 | |
| GSE53622 | NOTUM | 147111 | 27940 | 0.1714 | 0.1743 | |
| GSE53624 | NOTUM | 147111 | 27940 | 1.8540 | 0.0000 | |
| GSE63941 | NOTUM | 147111 | 228649_at | 0.3189 | 0.1932 | |
| GSE77861 | NOTUM | 147111 | 228649_at | 0.0296 | 0.9365 | |
| SRP133303 | NOTUM | 147111 | RNAseq | 2.4609 | 0.0000 | |
| SRP159526 | NOTUM | 147111 | RNAseq | 3.4033 | 0.0000 | |
| SRP219564 | NOTUM | 147111 | RNAseq | 2.2448 | 0.0003 | |
| TCGA | NOTUM | 147111 | RNAseq | 0.8847 | 0.0097 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by NOTUM expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NOTUM:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NOTUM | 147111 | 4 | 4 | 22 | |
| GSE20123 | NOTUM | 147111 | 4 | 4 | 22 | |
| GSE43470 | NOTUM | 147111 | 3 | 5 | 35 | |
| GSE46452 | NOTUM | 147111 | 34 | 0 | 25 | |
| GSE47630 | NOTUM | 147111 | 9 | 2 | 29 | |
| GSE54993 | NOTUM | 147111 | 2 | 5 | 63 | |
| GSE54994 | NOTUM | 147111 | 10 | 6 | 37 | |
| GSE60625 | NOTUM | 147111 | 6 | 0 | 5 | |
| GSE74703 | NOTUM | 147111 | 3 | 3 | 30 | |
| GSE74704 | NOTUM | 147111 | 4 | 3 | 13 | |
| TCGA | NOTUM | 147111 | 25 | 12 | 59 |
Total number of gains: 104; Total number of losses: 44; Total Number of normals: 340.
Somatic mutations of NOTUM:
Generating mutation plots.
Highly correlated genes for NOTUM:
Showing top 20/48 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NOTUM | GAD1 | 0.666466 | 3 | 0 | 3 |
| NOTUM | CHST8 | 0.664346 | 3 | 0 | 3 |
| NOTUM | PEAR1 | 0.635581 | 3 | 0 | 3 |
| NOTUM | SIX3-AS1 | 0.633514 | 3 | 0 | 3 |
| NOTUM | KIF1A | 0.626463 | 4 | 0 | 3 |
| NOTUM | HBQ1 | 0.625988 | 4 | 0 | 3 |
| NOTUM | GRIN1 | 0.619875 | 5 | 0 | 5 |
| NOTUM | C9orf131 | 0.619631 | 4 | 0 | 4 |
| NOTUM | HCRTR2 | 0.618293 | 3 | 0 | 3 |
| NOTUM | ADAMTS10 | 0.612779 | 3 | 0 | 3 |
| NOTUM | CDH2 | 0.607989 | 4 | 0 | 3 |
| NOTUM | ZNF483 | 0.604541 | 4 | 0 | 3 |
| NOTUM | CDH15 | 0.591642 | 4 | 0 | 3 |
| NOTUM | HOXB9 | 0.590859 | 3 | 0 | 3 |
| NOTUM | CSNK1E | 0.590474 | 4 | 0 | 3 |
| NOTUM | NOXO1 | 0.588936 | 4 | 0 | 4 |
| NOTUM | BMP3 | 0.583322 | 4 | 0 | 4 |
| NOTUM | TRIM54 | 0.577029 | 4 | 0 | 3 |
| NOTUM | RHOBTB2 | 0.576044 | 4 | 0 | 3 |
| NOTUM | TLE6 | 0.574948 | 3 | 0 | 3 |
For details and further investigation, click here
