| Full name: neuregulin 4 | Alias Symbol: HRG4 | ||
| Type: protein-coding gene | Cytoband: 15q24.2 | ||
| Entrez ID: 145957 | HGNC ID: HGNC:29862 | Ensembl Gene: ENSG00000169752 | OMIM ID: 610894 |
| Drug and gene relationship at DGIdb | |||
NRG4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04012 | ErbB signaling pathway |
Expression of NRG4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NRG4 | 145957 | 242426_at | 0.1769 | 0.5735 | |
| GSE26886 | NRG4 | 145957 | 242426_at | -0.2346 | 0.0474 | |
| GSE45670 | NRG4 | 145957 | 242426_at | 0.0297 | 0.8275 | |
| GSE53622 | NRG4 | 145957 | 40071 | -0.2201 | 0.3920 | |
| GSE53624 | NRG4 | 145957 | 18027 | -0.7768 | 0.0000 | |
| GSE63941 | NRG4 | 145957 | 242426_at | 0.8603 | 0.1100 | |
| GSE77861 | NRG4 | 145957 | 242426_at | -0.1786 | 0.1039 | |
| GSE97050 | NRG4 | 145957 | A_23_P334727 | -0.1401 | 0.6907 | |
| SRP064894 | NRG4 | 145957 | RNAseq | -0.1441 | 0.6228 | |
| SRP133303 | NRG4 | 145957 | RNAseq | 0.0966 | 0.7180 | |
| SRP159526 | NRG4 | 145957 | RNAseq | -0.0233 | 0.9731 | |
| SRP193095 | NRG4 | 145957 | RNAseq | -0.3082 | 0.3034 | |
| SRP219564 | NRG4 | 145957 | RNAseq | -0.5423 | 0.5033 | |
| TCGA | NRG4 | 145957 | RNAseq | -0.9727 | 0.0094 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NRG4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NRG4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NRG4 | 145957 | 8 | 1 | 21 | |
| GSE20123 | NRG4 | 145957 | 8 | 1 | 21 | |
| GSE43470 | NRG4 | 145957 | 4 | 6 | 33 | |
| GSE46452 | NRG4 | 145957 | 3 | 7 | 49 | |
| GSE47630 | NRG4 | 145957 | 8 | 10 | 22 | |
| GSE54993 | NRG4 | 145957 | 5 | 6 | 59 | |
| GSE54994 | NRG4 | 145957 | 5 | 6 | 42 | |
| GSE60625 | NRG4 | 145957 | 4 | 0 | 7 | |
| GSE74703 | NRG4 | 145957 | 4 | 3 | 29 | |
| GSE74704 | NRG4 | 145957 | 4 | 1 | 15 | |
| TCGA | NRG4 | 145957 | 14 | 15 | 67 |
Total number of gains: 67; Total number of losses: 56; Total Number of normals: 365.
Somatic mutations of NRG4:
Generating mutation plots.
Highly correlated genes for NRG4:
Showing top 20/41 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NRG4 | ZNRF2 | 0.754601 | 3 | 0 | 3 |
| NRG4 | OPN3 | 0.708744 | 3 | 0 | 3 |
| NRG4 | HOXD9 | 0.702298 | 3 | 0 | 3 |
| NRG4 | LUZP1 | 0.700563 | 3 | 0 | 3 |
| NRG4 | WDSUB1 | 0.695994 | 3 | 0 | 3 |
| NRG4 | NYNRIN | 0.69342 | 3 | 0 | 3 |
| NRG4 | ZBTB46 | 0.668033 | 3 | 0 | 3 |
| NRG4 | NCKAP5 | 0.666296 | 4 | 0 | 3 |
| NRG4 | HES2 | 0.658861 | 4 | 0 | 3 |
| NRG4 | HSF2BP | 0.653721 | 3 | 0 | 3 |
| NRG4 | SOX30 | 0.648079 | 3 | 0 | 3 |
| NRG4 | CARD6 | 0.645221 | 5 | 0 | 4 |
| NRG4 | DNAJB2 | 0.643677 | 3 | 0 | 3 |
| NRG4 | ABAT | 0.642056 | 4 | 0 | 3 |
| NRG4 | RIPK4 | 0.635072 | 4 | 0 | 4 |
| NRG4 | ESPL1 | 0.632103 | 3 | 0 | 3 |
| NRG4 | ICAM3 | 0.63068 | 3 | 0 | 3 |
| NRG4 | SFTA2 | 0.621252 | 3 | 0 | 3 |
| NRG4 | PFN4 | 0.619858 | 4 | 0 | 3 |
| NRG4 | MAP3K9 | 0.616233 | 5 | 0 | 4 |
For details and further investigation, click here
