PARP1

 

Full name: poly(ADP-ribose) polymerase 1 Alias Symbol: PARP
Type: protein-coding gene Cytoband: 1q42.12
Entrez ID: 142 HGNC ID: HGNC:270 Ensembl Gene: ENSG00000143799 OMIM ID: 173870
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PARP1 involved pathways:

KEGG pathway Description View
hsa04210Apoptosis

 

Expression of PARP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PARP1 142 208644_at 1.2234 0.0086
GSE20347 PARP1 142 208644_at 0.9272 0.0000
GSE23400 PARP1 142 208644_at 0.8382 0.0000
GSE26886 PARP1 142 208644_at 0.8193 0.0004
GSE29001 PARP1 142 208644_at 0.8908 0.0002
GSE38129 PARP1 142 208644_at 0.8700 0.0000
GSE45670 PARP1 142 208644_at 0.7408 0.0001
GSE53622 PARP1 142 29470 0.5702 0.0000
GSE53624 PARP1 142 29470 0.7259 0.0000
GSE63941 PARP1 142 208644_at 1.1062 0.0248
GSE77861 PARP1 142 208644_at 0.7986 0.0021
GSE97050 PARP1 142 A_33_P3290338 0.2240 0.4373
SRP007169 PARP1 142 RNAseq 1.2873 0.0013
SRP008496 PARP1 142 RNAseq 1.2877 0.0000
SRP064894 PARP1 142 RNAseq 0.7246 0.0000
SRP133303 PARP1 142 RNAseq 0.7264 0.0002
SRP159526 PARP1 142 RNAseq 0.7937 0.0291
SRP193095 PARP1 142 RNAseq 0.7387 0.0000
SRP219564 PARP1 142 RNAseq 0.8112 0.0569
TCGA PARP1 142 RNAseq 0.1917 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by PARP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PARP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PARP1 142 11 0 19
GSE20123 PARP1 142 11 0 19
GSE43470 PARP1 142 7 1 35
GSE46452 PARP1 142 3 1 55
GSE47630 PARP1 142 15 0 25
GSE54993 PARP1 142 0 6 64
GSE54994 PARP1 142 16 0 37
GSE60625 PARP1 142 0 0 11
GSE74703 PARP1 142 7 1 28
GSE74704 PARP1 142 5 0 15
TCGA PARP1 142 46 3 47

Total number of gains: 121; Total number of losses: 12; Total Number of normals: 355.  

 

Somatic mutations of PARP1:

 

Generating mutation plots.

 

Highly correlated genes for PARP1:

 

Showing top 20/1909 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PARP1MSH60.78904413013
PARP1SNRPE0.78850512012
PARP1SNAP470.761941404
PARP1MCM30.76117312012
PARP1CERS20.758168909
PARP1CKS1B0.75583312012
PARP1C1orf1120.74761611011
PARP1GORAB0.745352707
PARP1RFC40.74189513013
PARP1MARCKSL10.74142511011
PARP1RUVBL10.73895112011
PARP1CDCA20.735774505
PARP1DTL0.73546313012
PARP1APMAP0.73412510010
PARP1DNMT10.73218413012
PARP1GINS20.72813211011
PARP1HEATR10.72772112011
PARP1E2F60.72747212011
PARP1COMMD70.726871303
PARP1MCM20.72620812010

For details and further investigation, click here