OSMR

 

Full name: oncostatin M receptor Alias Symbol: OSMRB
Type: protein-coding gene Cytoband: 5p13.1
Entrez ID: 9180 HGNC ID: HGNC:8507 Ensembl Gene: ENSG00000145623 OMIM ID: 601743
Drug and gene relationship at DGIdb

 

OSMR involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04630Jak-STAT signaling pathway

 

Expression of OSMR:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 OSMR 9180 1554008_at 0.3997 0.5780
GSE20347 OSMR 9180 205729_at 0.5349 0.0108
GSE23400 OSMR 9180 205729_at 0.6206 0.0000
GSE26886 OSMR 9180 1554008_at 2.1051 0.0000
GSE29001 OSMR 9180 205729_at 0.5535 0.0047
GSE38129 OSMR 9180 205729_at 0.8478 0.0001
GSE45670 OSMR 9180 1554008_at 1.0674 0.0169
GSE53622 OSMR 9180 25690 1.1650 0.0000
GSE53624 OSMR 9180 25690 1.0927 0.0000
GSE63941 OSMR 9180 1554008_at 0.3977 0.7628
GSE77861 OSMR 9180 1554008_at 0.7505 0.1111
GSE97050 OSMR 9180 A_23_P156289 1.1678 0.0892
SRP007169 OSMR 9180 RNAseq 2.6032 0.0000
SRP008496 OSMR 9180 RNAseq 1.9958 0.0000
SRP064894 OSMR 9180 RNAseq 0.6528 0.0376
SRP133303 OSMR 9180 RNAseq 1.0709 0.0001
SRP159526 OSMR 9180 RNAseq 0.5457 0.1142
SRP193095 OSMR 9180 RNAseq 1.4989 0.0000
SRP219564 OSMR 9180 RNAseq 0.6234 0.1177
TCGA OSMR 9180 RNAseq 0.2200 0.0136

Upregulated datasets: 8; Downregulated datasets: 0.  

 

Survival by OSMR expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of OSMR:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 OSMR 9180 10 0 20
GSE20123 OSMR 9180 10 0 20
GSE43470 OSMR 9180 17 0 26
GSE46452 OSMR 9180 5 22 32
GSE47630 OSMR 9180 6 12 22
GSE54993 OSMR 9180 5 4 61
GSE54994 OSMR 9180 25 2 26
GSE60625 OSMR 9180 0 0 11
GSE74703 OSMR 9180 13 0 23
GSE74704 OSMR 9180 9 0 11
TCGA OSMR 9180 55 5 36

Total number of gains: 155; Total number of losses: 45; Total Number of normals: 288.  

 

Somatic mutations of OSMR:

 

Generating mutation plots.

 

Highly correlated genes for OSMR:

 

Showing top 20/973 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
OSMRDCBLD10.726581706
OSMRZNF1140.712629404
OSMRCD2760.686217404
OSMRSPOCD10.68562505
OSMRLOXL20.6784611010
OSMRITGB40.67835610010
OSMRFBLIM10.677992606
OSMRPLAU0.67501911010
OSMRSLC19A10.673616303
OSMRFMNL20.671431807
OSMRTTYH30.670495706
OSMRLAMC20.66857612011
OSMRSERPINE10.66781612010
OSMRBGN0.665297908
OSMRCDCA20.66215404
OSMRCOL27A10.661743505
OSMRUHRF10.653169605
OSMRWDR660.652568706
OSMRINHBA0.65251611010
OSMRTRIP130.65248511010

For details and further investigation, click here