| Full name: par-6 family cell polarity regulator gamma | Alias Symbol: PAR-6G|PAR6gamma | ||
| Type: protein-coding gene | Cytoband: 18q23 | ||
| Entrez ID: 84552 | HGNC ID: HGNC:16076 | Ensembl Gene: ENSG00000178184 | OMIM ID: 608976 |
| Drug and gene relationship at DGIdb | |||
PARD6G involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04360 | Axon guidance | |
| hsa04530 | Tight junction |
Expression of PARD6G:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PARD6G | 84552 | 227204_at | 0.0444 | 0.9542 | |
| GSE26886 | PARD6G | 84552 | 227204_at | -0.9514 | 0.0000 | |
| GSE45670 | PARD6G | 84552 | 227204_at | 0.0769 | 0.7036 | |
| GSE53622 | PARD6G | 84552 | 11379 | -0.1667 | 0.2439 | |
| GSE53624 | PARD6G | 84552 | 11379 | -0.2971 | 0.0057 | |
| GSE63941 | PARD6G | 84552 | 227204_at | -0.7082 | 0.3263 | |
| GSE77861 | PARD6G | 84552 | 227204_at | 0.2530 | 0.3706 | |
| GSE97050 | PARD6G | 84552 | A_24_P74070 | 0.1724 | 0.5830 | |
| SRP007169 | PARD6G | 84552 | RNAseq | -1.2348 | 0.0006 | |
| SRP008496 | PARD6G | 84552 | RNAseq | -0.7565 | 0.0200 | |
| SRP064894 | PARD6G | 84552 | RNAseq | -0.2789 | 0.2304 | |
| SRP133303 | PARD6G | 84552 | RNAseq | -0.1779 | 0.2826 | |
| SRP159526 | PARD6G | 84552 | RNAseq | 0.0120 | 0.9762 | |
| SRP193095 | PARD6G | 84552 | RNAseq | -0.2857 | 0.2662 | |
| SRP219564 | PARD6G | 84552 | RNAseq | -1.1868 | 0.0090 | |
| TCGA | PARD6G | 84552 | RNAseq | 0.5945 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PARD6G expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PARD6G:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PARD6G | 84552 | 1 | 12 | 17 | |
| GSE20123 | PARD6G | 84552 | 1 | 12 | 17 | |
| GSE43470 | PARD6G | 84552 | 0 | 12 | 31 | |
| GSE46452 | PARD6G | 84552 | 1 | 26 | 32 | |
| GSE47630 | PARD6G | 84552 | 5 | 22 | 13 | |
| GSE54993 | PARD6G | 84552 | 9 | 0 | 61 | |
| GSE54994 | PARD6G | 84552 | 1 | 19 | 33 | |
| GSE60625 | PARD6G | 84552 | 0 | 4 | 7 | |
| GSE74703 | PARD6G | 84552 | 0 | 8 | 28 | |
| GSE74704 | PARD6G | 84552 | 0 | 9 | 11 | |
| TCGA | PARD6G | 84552 | 7 | 45 | 44 |
Total number of gains: 25; Total number of losses: 169; Total Number of normals: 294.
Somatic mutations of PARD6G:
Generating mutation plots.
Highly correlated genes for PARD6G:
Showing top 20/218 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PARD6G | GJB6 | 0.724695 | 4 | 0 | 4 |
| PARD6G | TGM1 | 0.71776 | 4 | 0 | 4 |
| PARD6G | CLIC3 | 0.717686 | 3 | 0 | 3 |
| PARD6G | RNPEP | 0.714492 | 3 | 0 | 3 |
| PARD6G | SULT2B1 | 0.693567 | 3 | 0 | 3 |
| PARD6G | FUT2 | 0.687408 | 3 | 0 | 3 |
| PARD6G | TMPRSS11D | 0.675327 | 5 | 0 | 4 |
| PARD6G | PRDM1 | 0.671152 | 4 | 0 | 3 |
| PARD6G | PI3 | 0.660869 | 5 | 0 | 4 |
| PARD6G | GRHL1 | 0.653906 | 5 | 0 | 4 |
| PARD6G | PTBP3 | 0.648437 | 4 | 0 | 4 |
| PARD6G | MREG | 0.646451 | 5 | 0 | 4 |
| PARD6G | TMEM134 | 0.645535 | 4 | 0 | 4 |
| PARD6G | EPHX3 | 0.645303 | 4 | 0 | 3 |
| PARD6G | VAMP8 | 0.643656 | 4 | 0 | 3 |
| PARD6G | USH1G | 0.643145 | 3 | 0 | 3 |
| PARD6G | GUCA1B | 0.641605 | 3 | 0 | 3 |
| PARD6G | C15orf48 | 0.641183 | 4 | 0 | 3 |
| PARD6G | TBC1D22B | 0.638535 | 3 | 0 | 3 |
| PARD6G | EIF4E | 0.637707 | 4 | 0 | 3 |
For details and further investigation, click here
