| Full name: PCF11 cleavage and polyadenylation factor subunit | Alias Symbol: KIAA0824 | ||
| Type: protein-coding gene | Cytoband: 11q14.1 | ||
| Entrez ID: 51585 | HGNC ID: HGNC:30097 | Ensembl Gene: ENSG00000165494 | OMIM ID: 608876 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PCF11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCF11 | 51585 | 227622_at | -0.3877 | 0.5476 | |
| GSE20347 | PCF11 | 51585 | 203378_at | -0.4759 | 0.0179 | |
| GSE23400 | PCF11 | 51585 | 203378_at | -0.1650 | 0.0214 | |
| GSE26886 | PCF11 | 51585 | 227622_at | -0.1035 | 0.6830 | |
| GSE29001 | PCF11 | 51585 | 203378_at | -0.4870 | 0.1155 | |
| GSE38129 | PCF11 | 51585 | 203378_at | -0.5952 | 0.0006 | |
| GSE45670 | PCF11 | 51585 | 227622_at | -0.4185 | 0.0277 | |
| GSE63941 | PCF11 | 51585 | 227622_at | 0.1260 | 0.7600 | |
| GSE77861 | PCF11 | 51585 | 227622_at | 0.0693 | 0.6106 | |
| GSE97050 | PCF11 | 51585 | A_33_P3210139 | -0.5888 | 0.1065 | |
| SRP007169 | PCF11 | 51585 | RNAseq | -0.1314 | 0.7342 | |
| SRP008496 | PCF11 | 51585 | RNAseq | -0.3140 | 0.2049 | |
| SRP064894 | PCF11 | 51585 | RNAseq | -0.6554 | 0.0067 | |
| SRP133303 | PCF11 | 51585 | RNAseq | -0.7477 | 0.0000 | |
| SRP159526 | PCF11 | 51585 | RNAseq | -0.8860 | 0.0001 | |
| SRP193095 | PCF11 | 51585 | RNAseq | -0.5763 | 0.0000 | |
| SRP219564 | PCF11 | 51585 | RNAseq | -0.8102 | 0.0355 | |
| TCGA | PCF11 | 51585 | RNAseq | -0.1796 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PCF11 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PCF11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCF11 | 51585 | 2 | 9 | 19 | |
| GSE20123 | PCF11 | 51585 | 2 | 9 | 19 | |
| GSE43470 | PCF11 | 51585 | 3 | 4 | 36 | |
| GSE46452 | PCF11 | 51585 | 5 | 23 | 31 | |
| GSE47630 | PCF11 | 51585 | 3 | 18 | 19 | |
| GSE54993 | PCF11 | 51585 | 8 | 2 | 60 | |
| GSE54994 | PCF11 | 51585 | 6 | 18 | 29 | |
| GSE60625 | PCF11 | 51585 | 0 | 3 | 8 | |
| GSE74703 | PCF11 | 51585 | 2 | 3 | 31 | |
| GSE74704 | PCF11 | 51585 | 2 | 6 | 12 | |
| TCGA | PCF11 | 51585 | 18 | 36 | 42 |
Total number of gains: 51; Total number of losses: 131; Total Number of normals: 306.
Somatic mutations of PCF11:
Generating mutation plots.
Highly correlated genes for PCF11:
Showing top 20/55 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCF11 | NTN4 | 0.657469 | 3 | 0 | 3 |
| PCF11 | B3GALNT2 | 0.618789 | 3 | 0 | 3 |
| PCF11 | CDK19 | 0.618401 | 5 | 0 | 4 |
| PCF11 | SYF2 | 0.612135 | 4 | 0 | 4 |
| PCF11 | ACACB | 0.601207 | 3 | 0 | 3 |
| PCF11 | EID3 | 0.587813 | 3 | 0 | 3 |
| PCF11 | BEX4 | 0.576698 | 4 | 0 | 3 |
| PCF11 | CES1 | 0.564247 | 5 | 0 | 3 |
| PCF11 | DOCK3 | 0.562148 | 4 | 0 | 3 |
| PCF11 | PHF2 | 0.562066 | 4 | 0 | 3 |
| PCF11 | TRPC1 | 0.559064 | 4 | 0 | 3 |
| PCF11 | FAM149B1 | 0.550698 | 6 | 0 | 4 |
| PCF11 | AZI2 | 0.550578 | 3 | 0 | 3 |
| PCF11 | METTL7A | 0.549688 | 5 | 0 | 4 |
| PCF11 | GOLGA8N | 0.54883 | 7 | 0 | 5 |
| PCF11 | VPS13D | 0.548762 | 6 | 0 | 4 |
| PCF11 | CREBZF | 0.548544 | 3 | 0 | 3 |
| PCF11 | TLR5 | 0.548426 | 3 | 0 | 3 |
| PCF11 | USP9X | 0.548035 | 5 | 0 | 3 |
| PCF11 | AFF1 | 0.546299 | 6 | 0 | 4 |
For details and further investigation, click here
