| Full name: PGAM family member 5, mitochondrial serine/threonine protein phosphatase | Alias Symbol: MGC5352|BXLBv68 | ||
| Type: protein-coding gene | Cytoband: 12q24.33 | ||
| Entrez ID: 192111 | HGNC ID: HGNC:28763 | Ensembl Gene: ENSG00000247077 | OMIM ID: 614939 |
| Drug and gene relationship at DGIdb | |||
PGAM5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04668 | TNF signaling pathway |
Expression of PGAM5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PGAM5 | 192111 | 1555943_at | 1.0350 | 0.1276 | |
| GSE26886 | PGAM5 | 192111 | 1555943_at | 0.2964 | 0.1250 | |
| GSE45670 | PGAM5 | 192111 | 1555943_at | 0.5160 | 0.0096 | |
| GSE53622 | PGAM5 | 192111 | 9074 | 0.5088 | 0.0000 | |
| GSE53624 | PGAM5 | 192111 | 9074 | 0.5014 | 0.0000 | |
| GSE63941 | PGAM5 | 192111 | 1555943_at | 1.3114 | 0.0012 | |
| GSE77861 | PGAM5 | 192111 | 1555943_at | 0.1196 | 0.3361 | |
| GSE97050 | PGAM5 | 192111 | A_23_P319719 | 0.3573 | 0.3228 | |
| SRP007169 | PGAM5 | 192111 | RNAseq | 0.3515 | 0.2807 | |
| SRP008496 | PGAM5 | 192111 | RNAseq | 0.2500 | 0.3160 | |
| SRP064894 | PGAM5 | 192111 | RNAseq | 0.5003 | 0.0097 | |
| SRP133303 | PGAM5 | 192111 | RNAseq | 0.4361 | 0.0069 | |
| SRP159526 | PGAM5 | 192111 | RNAseq | 0.5821 | 0.0032 | |
| SRP193095 | PGAM5 | 192111 | RNAseq | 0.5580 | 0.0000 | |
| SRP219564 | PGAM5 | 192111 | RNAseq | 0.1713 | 0.6318 | |
| TCGA | PGAM5 | 192111 | RNAseq | 0.2598 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PGAM5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PGAM5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PGAM5 | 192111 | 4 | 5 | 21 | |
| GSE20123 | PGAM5 | 192111 | 4 | 5 | 21 | |
| GSE43470 | PGAM5 | 192111 | 3 | 3 | 37 | |
| GSE46452 | PGAM5 | 192111 | 8 | 3 | 48 | |
| GSE47630 | PGAM5 | 192111 | 9 | 3 | 28 | |
| GSE54993 | PGAM5 | 192111 | 0 | 6 | 64 | |
| GSE54994 | PGAM5 | 192111 | 4 | 8 | 41 | |
| GSE60625 | PGAM5 | 192111 | 1 | 0 | 10 | |
| GSE74703 | PGAM5 | 192111 | 2 | 3 | 31 | |
| GSE74704 | PGAM5 | 192111 | 2 | 3 | 15 | |
| TCGA | PGAM5 | 192111 | 21 | 15 | 60 |
Total number of gains: 58; Total number of losses: 54; Total Number of normals: 376.
Somatic mutations of PGAM5:
Generating mutation plots.
Highly correlated genes for PGAM5:
Showing top 20/869 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PGAM5 | CDC37 | 0.718876 | 4 | 0 | 4 |
| PGAM5 | PKMYT1 | 0.718484 | 4 | 0 | 4 |
| PGAM5 | VRK1 | 0.717724 | 5 | 0 | 5 |
| PGAM5 | LSM4 | 0.713792 | 4 | 0 | 4 |
| PGAM5 | RFC2 | 0.713347 | 5 | 0 | 5 |
| PGAM5 | AP2M1 | 0.71194 | 4 | 0 | 4 |
| PGAM5 | DNAJC9 | 0.70027 | 5 | 0 | 4 |
| PGAM5 | STIL | 0.697747 | 7 | 0 | 7 |
| PGAM5 | TMPO | 0.694277 | 3 | 0 | 3 |
| PGAM5 | TRAIP | 0.691352 | 5 | 0 | 5 |
| PGAM5 | NUP160 | 0.690541 | 3 | 0 | 3 |
| PGAM5 | IFI16 | 0.688602 | 3 | 0 | 3 |
| PGAM5 | EIF2S1 | 0.687651 | 3 | 0 | 3 |
| PGAM5 | ARHGAP11A | 0.686619 | 5 | 0 | 4 |
| PGAM5 | NCAPH | 0.685553 | 4 | 0 | 4 |
| PGAM5 | MCMBP | 0.684327 | 5 | 0 | 5 |
| PGAM5 | RNASEH2A | 0.681934 | 8 | 0 | 7 |
| PGAM5 | PAM16 | 0.681259 | 3 | 0 | 3 |
| PGAM5 | CDC20 | 0.681241 | 7 | 0 | 7 |
| PGAM5 | BCL2L12 | 0.680097 | 7 | 0 | 6 |
For details and further investigation, click here
