ARHGAP11A

 

Full name: Rho GTPase activating protein 11A Alias Symbol: KIAA0013
Type: protein-coding gene Cytoband: 15q13.3
Entrez ID: 9824 HGNC ID: HGNC:15783 Ensembl Gene: ENSG00000198826 OMIM ID: 610589
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of ARHGAP11A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ARHGAP11A 9824 204492_at 0.6624 0.2777
GSE20347 ARHGAP11A 9824 204492_at 0.3313 0.0030
GSE23400 ARHGAP11A 9824 204492_at 0.0831 0.0048
GSE26886 ARHGAP11A 9824 204492_at -0.0823 0.7040
GSE29001 ARHGAP11A 9824 204492_at 0.3965 0.0551
GSE38129 ARHGAP11A 9824 204492_at 0.5403 0.0000
GSE45670 ARHGAP11A 9824 204492_at 0.5692 0.0229
GSE53622 ARHGAP11A 9824 58565 1.5425 0.0000
GSE53624 ARHGAP11A 9824 58565 1.4139 0.0000
GSE63941 ARHGAP11A 9824 204492_at 0.3913 0.5766
GSE77861 ARHGAP11A 9824 204492_at 0.0053 0.9725
GSE97050 ARHGAP11A 9824 A_33_P3339361 0.8154 0.3051
SRP007169 ARHGAP11A 9824 RNAseq 2.0516 0.0000
SRP008496 ARHGAP11A 9824 RNAseq 1.6256 0.0001
SRP064894 ARHGAP11A 9824 RNAseq 0.8869 0.0025
SRP133303 ARHGAP11A 9824 RNAseq 1.4056 0.0000
SRP159526 ARHGAP11A 9824 RNAseq 1.1004 0.0000
SRP193095 ARHGAP11A 9824 RNAseq 0.8011 0.0000
SRP219564 ARHGAP11A 9824 RNAseq 0.2544 0.6885
TCGA ARHGAP11A 9824 RNAseq 0.8200 0.0000

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by ARHGAP11A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ARHGAP11A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ARHGAP11A 9824 2 7 21
GSE20123 ARHGAP11A 9824 2 7 21
GSE43470 ARHGAP11A 9824 4 4 35
GSE46452 ARHGAP11A 9824 3 7 49
GSE47630 ARHGAP11A 9824 8 11 21
GSE54993 ARHGAP11A 9824 4 6 60
GSE54994 ARHGAP11A 9824 5 8 40
GSE60625 ARHGAP11A 9824 4 0 7
GSE74703 ARHGAP11A 9824 4 3 29
GSE74704 ARHGAP11A 9824 1 6 13
TCGA ARHGAP11A 9824 15 16 65

Total number of gains: 52; Total number of losses: 75; Total Number of normals: 361.  

 

Somatic mutations of ARHGAP11A:

 

Generating mutation plots.

 

Highly correlated genes for ARHGAP11A:

 

Showing top 20/763 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ARHGAP11AKNSTRN0.733481505
ARHGAP11ALSM40.728263404
ARHGAP11ATUBA1B0.720833505
ARHGAP11AOIP50.72051908
ARHGAP11AANLN0.718729606
ARHGAP11AKIF230.7023061109
ARHGAP11APRC10.7016561009
ARHGAP11ABUB10.701534908
ARHGAP11ACCNA20.699529909
ARHGAP11ATIMMDC10.695998303
ARHGAP11ACKAP2L0.695555606
ARHGAP11AMRPL510.695056404
ARHGAP11ACDCA70.693959303
ARHGAP11ACEP550.6873151008
ARHGAP11APGAM50.686619504
ARHGAP11ADTL0.684072807
ARHGAP11AMCM100.6838791008
ARHGAP11APLK40.68339212011
ARHGAP11AKDM1A0.682428505
ARHGAP11ARFC40.682427807

For details and further investigation, click here