| Full name: pleckstrin homology domain containing A6 | Alias Symbol: PEPP3|KIAA0969 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 22874 | HGNC ID: HGNC:17053 | Ensembl Gene: ENSG00000143850 | OMIM ID: 607771 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHA6 | 22874 | 205093_at | -0.5139 | 0.3327 | |
| GSE20347 | PLEKHA6 | 22874 | 205093_at | -0.5694 | 0.0000 | |
| GSE23400 | PLEKHA6 | 22874 | 205093_at | -0.6661 | 0.0000 | |
| GSE26886 | PLEKHA6 | 22874 | 205093_at | -2.1617 | 0.0000 | |
| GSE29001 | PLEKHA6 | 22874 | 205093_at | -1.0275 | 0.0004 | |
| GSE38129 | PLEKHA6 | 22874 | 205093_at | -0.7451 | 0.0000 | |
| GSE45670 | PLEKHA6 | 22874 | 205093_at | -0.4605 | 0.0484 | |
| GSE53622 | PLEKHA6 | 22874 | 74080 | -2.2730 | 0.0000 | |
| GSE53624 | PLEKHA6 | 22874 | 74080 | -2.4398 | 0.0000 | |
| GSE63941 | PLEKHA6 | 22874 | 205093_at | -0.1552 | 0.7363 | |
| GSE77861 | PLEKHA6 | 22874 | 205093_at | -0.5007 | 0.0143 | |
| GSE97050 | PLEKHA6 | 22874 | A_23_P431268 | -0.8869 | 0.1143 | |
| SRP007169 | PLEKHA6 | 22874 | RNAseq | -4.5918 | 0.0000 | |
| SRP008496 | PLEKHA6 | 22874 | RNAseq | -4.1237 | 0.0000 | |
| SRP064894 | PLEKHA6 | 22874 | RNAseq | -2.9530 | 0.0000 | |
| SRP133303 | PLEKHA6 | 22874 | RNAseq | -1.7718 | 0.0000 | |
| SRP159526 | PLEKHA6 | 22874 | RNAseq | -2.5631 | 0.0000 | |
| SRP193095 | PLEKHA6 | 22874 | RNAseq | -1.3441 | 0.0016 | |
| SRP219564 | PLEKHA6 | 22874 | RNAseq | -0.0912 | 0.9247 | |
| TCGA | PLEKHA6 | 22874 | RNAseq | -1.3087 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by PLEKHA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHA6 | 22874 | 11 | 0 | 19 | |
| GSE20123 | PLEKHA6 | 22874 | 11 | 0 | 19 | |
| GSE43470 | PLEKHA6 | 22874 | 6 | 0 | 37 | |
| GSE46452 | PLEKHA6 | 22874 | 3 | 1 | 55 | |
| GSE47630 | PLEKHA6 | 22874 | 14 | 0 | 26 | |
| GSE54993 | PLEKHA6 | 22874 | 0 | 6 | 64 | |
| GSE54994 | PLEKHA6 | 22874 | 15 | 0 | 38 | |
| GSE60625 | PLEKHA6 | 22874 | 0 | 0 | 11 | |
| GSE74703 | PLEKHA6 | 22874 | 6 | 0 | 30 | |
| GSE74704 | PLEKHA6 | 22874 | 5 | 0 | 15 | |
| TCGA | PLEKHA6 | 22874 | 43 | 4 | 49 |
Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.
Somatic mutations of PLEKHA6:
Generating mutation plots.
Highly correlated genes for PLEKHA6:
Showing top 20/1661 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHA6 | MPP7 | 0.810565 | 6 | 0 | 6 |
| PLEKHA6 | SORT1 | 0.80386 | 10 | 0 | 10 |
| PLEKHA6 | PADI1 | 0.798358 | 8 | 0 | 8 |
| PLEKHA6 | RMND5B | 0.796586 | 11 | 0 | 11 |
| PLEKHA6 | ARHGEF10L | 0.789744 | 12 | 0 | 12 |
| PLEKHA6 | CGNL1 | 0.785132 | 7 | 0 | 7 |
| PLEKHA6 | EPB41L4A | 0.785032 | 7 | 0 | 7 |
| PLEKHA6 | PPP1R3C | 0.776904 | 10 | 0 | 10 |
| PLEKHA6 | CAPN14 | 0.775769 | 5 | 0 | 5 |
| PLEKHA6 | FNDC4 | 0.774961 | 10 | 0 | 9 |
| PLEKHA6 | GYS2 | 0.773292 | 10 | 0 | 10 |
| PLEKHA6 | SASH1 | 0.772154 | 11 | 0 | 10 |
| PLEKHA6 | CLEC3B | 0.76936 | 3 | 0 | 3 |
| PLEKHA6 | UPK1A | 0.767558 | 10 | 0 | 10 |
| PLEKHA6 | ACOX3 | 0.765285 | 11 | 0 | 11 |
| PLEKHA6 | CPEB3 | 0.764813 | 10 | 0 | 10 |
| PLEKHA6 | CAB39L | 0.762103 | 12 | 0 | 12 |
| PLEKHA6 | ACOX1 | 0.759889 | 10 | 0 | 10 |
| PLEKHA6 | STRADB | 0.757588 | 7 | 0 | 7 |
| PLEKHA6 | ECHDC2 | 0.754681 | 12 | 0 | 11 |
For details and further investigation, click here
