PMAIP1

 

Full name: phorbol-12-myristate-13-acetate-induced protein 1 Alias Symbol: APR|NOXA
Type: protein-coding gene Cytoband: 18q21.32
Entrez ID: 5366 HGNC ID: HGNC:9108 Ensembl Gene: ENSG00000141682 OMIM ID: 604959
Drug and gene relationship at DGIdb

 

PMAIP1 involved pathways:

KEGG pathway Description View
hsa04115p53 signaling pathway
hsa04210Apoptosis

 

Expression of PMAIP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PMAIP1 5366 204285_s_at 0.1555 0.9194
GSE20347 PMAIP1 5366 204285_s_at 0.4501 0.1992
GSE23400 PMAIP1 5366 204285_s_at 0.2540 0.1248
GSE26886 PMAIP1 5366 204286_s_at -1.4805 0.0014
GSE29001 PMAIP1 5366 204285_s_at 0.3380 0.5163
GSE38129 PMAIP1 5366 204285_s_at 1.0132 0.0057
GSE45670 PMAIP1 5366 204285_s_at 1.0174 0.0015
GSE53622 PMAIP1 5366 24037 0.7051 0.0000
GSE53624 PMAIP1 5366 24037 0.6430 0.0000
GSE63941 PMAIP1 5366 204285_s_at 1.6927 0.0071
GSE77861 PMAIP1 5366 204285_s_at 0.8105 0.2287
GSE97050 PMAIP1 5366 A_33_P3619171 0.2760 0.5143
SRP007169 PMAIP1 5366 RNAseq -0.8064 0.1197
SRP008496 PMAIP1 5366 RNAseq -1.1235 0.0133
SRP064894 PMAIP1 5366 RNAseq 0.3086 0.4915
SRP133303 PMAIP1 5366 RNAseq 0.7964 0.0295
SRP159526 PMAIP1 5366 RNAseq 0.1427 0.6841
SRP193095 PMAIP1 5366 RNAseq -0.5482 0.1306
SRP219564 PMAIP1 5366 RNAseq 0.1110 0.8799
TCGA PMAIP1 5366 RNAseq 0.7458 0.0000

Upregulated datasets: 3; Downregulated datasets: 2.  

 

Survival by PMAIP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PMAIP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PMAIP1 5366 1 9 20
GSE20123 PMAIP1 5366 1 9 20
GSE43470 PMAIP1 5366 0 5 38
GSE46452 PMAIP1 5366 1 26 32
GSE47630 PMAIP1 5366 5 20 15
GSE54993 PMAIP1 5366 10 0 60
GSE54994 PMAIP1 5366 1 17 35
GSE60625 PMAIP1 5366 0 4 7
GSE74703 PMAIP1 5366 0 5 31
GSE74704 PMAIP1 5366 1 6 13
TCGA PMAIP1 5366 9 44 43

Total number of gains: 29; Total number of losses: 145; Total Number of normals: 314.  

 

Somatic mutations of PMAIP1:

 

Generating mutation plots.

 

Highly correlated genes for PMAIP1:

 

Showing top 20/58 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PMAIP1NME90.658204303
PMAIP1RPRD1A0.643672303
PMAIP1RASGEF1B0.633486303
PMAIP1RNGTT0.63005404
PMAIP1GSTA30.629307303
PMAIP1GRPEL10.611956303
PMAIP1GGH0.608644504
PMAIP1PPAT0.597667303
PMAIP1LPAR30.595351303
PMAIP1GNL3L0.592475303
PMAIP1EDEM10.586262303
PMAIP1WTAP0.579895303
PMAIP1TUBGCP40.571529403
PMAIP1UCK20.567005303
PMAIP1CCNB20.557993704
PMAIP1POLR1C0.556383303
PMAIP1CEP850.554714503
PMAIP1JAG10.553498303
PMAIP1KIF20A0.553179503
PMAIP1BIRC50.547039604

For details and further investigation, click here