| Full name: patatin like phospholipase domain containing 1 | Alias Symbol: FLJ38755|dJ50J22.1 | ||
| Type: protein-coding gene | Cytoband: 6p21.31 | ||
| Entrez ID: 285848 | HGNC ID: HGNC:21246 | Ensembl Gene: ENSG00000180316 | OMIM ID: 612121 |
| Drug and gene relationship at DGIdb | |||
Expression of PNPLA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PNPLA1 | 285848 | 1553364_at | 0.2212 | 0.3125 | |
| GSE26886 | PNPLA1 | 285848 | 1553364_at | 0.1534 | 0.1424 | |
| GSE45670 | PNPLA1 | 285848 | 1553364_at | 0.3802 | 0.1122 | |
| GSE53622 | PNPLA1 | 285848 | 59775 | 2.2378 | 0.0000 | |
| GSE53624 | PNPLA1 | 285848 | 59775 | 2.4594 | 0.0000 | |
| GSE63941 | PNPLA1 | 285848 | 1553364_at | 0.0427 | 0.7276 | |
| GSE77861 | PNPLA1 | 285848 | 1553364_at | 0.0074 | 0.9387 | |
| GSE97050 | PNPLA1 | 285848 | A_32_P526255 | 0.1826 | 0.5480 | |
| SRP133303 | PNPLA1 | 285848 | RNAseq | 0.6031 | 0.0160 | |
| SRP193095 | PNPLA1 | 285848 | RNAseq | 1.1011 | 0.0002 | |
| TCGA | PNPLA1 | 285848 | RNAseq | -1.1211 | 0.0150 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by PNPLA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PNPLA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PNPLA1 | 285848 | 5 | 0 | 25 | |
| GSE20123 | PNPLA1 | 285848 | 5 | 0 | 25 | |
| GSE43470 | PNPLA1 | 285848 | 5 | 1 | 37 | |
| GSE46452 | PNPLA1 | 285848 | 2 | 9 | 48 | |
| GSE47630 | PNPLA1 | 285848 | 8 | 4 | 28 | |
| GSE54993 | PNPLA1 | 285848 | 3 | 1 | 66 | |
| GSE54994 | PNPLA1 | 285848 | 10 | 5 | 38 | |
| GSE60625 | PNPLA1 | 285848 | 1 | 0 | 10 | |
| GSE74703 | PNPLA1 | 285848 | 5 | 0 | 31 | |
| GSE74704 | PNPLA1 | 285848 | 2 | 0 | 18 | |
| TCGA | PNPLA1 | 285848 | 15 | 15 | 66 |
Total number of gains: 61; Total number of losses: 35; Total Number of normals: 392.
Somatic mutations of PNPLA1:
Generating mutation plots.
Highly correlated genes for PNPLA1:
Showing top 20/137 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PNPLA1 | MUCL1 | 0.663192 | 4 | 0 | 4 |
| PNPLA1 | CDSN | 0.648636 | 4 | 0 | 3 |
| PNPLA1 | CHST1 | 0.613378 | 6 | 0 | 6 |
| PNPLA1 | GPRIN1 | 0.604135 | 4 | 0 | 3 |
| PNPLA1 | LBX2-AS1 | 0.601743 | 4 | 0 | 3 |
| PNPLA1 | ABCA12 | 0.597278 | 5 | 0 | 4 |
| PNPLA1 | DPY19L4 | 0.594784 | 4 | 0 | 3 |
| PNPLA1 | U2SURP | 0.594446 | 3 | 0 | 3 |
| PNPLA1 | LRRC15 | 0.593687 | 5 | 0 | 4 |
| PNPLA1 | FARP1 | 0.59084 | 4 | 0 | 3 |
| PNPLA1 | KDM6B | 0.587851 | 3 | 0 | 3 |
| PNPLA1 | PDE7A | 0.586172 | 3 | 0 | 3 |
| PNPLA1 | SHF | 0.585683 | 3 | 0 | 3 |
| PNPLA1 | CCNA1 | 0.584694 | 4 | 0 | 3 |
| PNPLA1 | CYP27B1 | 0.582797 | 3 | 0 | 3 |
| PNPLA1 | ATP6V0D2 | 0.582013 | 3 | 0 | 3 |
| PNPLA1 | CFHR4 | 0.58144 | 4 | 0 | 3 |
| PNPLA1 | MMP11 | 0.580763 | 5 | 0 | 4 |
| PNPLA1 | ESM1 | 0.577817 | 4 | 0 | 4 |
| PNPLA1 | PLAUR | 0.576389 | 4 | 0 | 3 |
For details and further investigation, click here
