| Full name: pro-platelet basic protein | Alias Symbol: SCYB7|TGB|NAP-2-L1|LA-PF4|MDGF|LDGF|Beta-TG|CTAP3|CXCL7|PBP|b-TG1|TGB1|CTAPIII|NAP-2 | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 5473 | HGNC ID: HGNC:9240 | Ensembl Gene: ENSG00000163736 | OMIM ID: 121010 |
| Drug and gene relationship at DGIdb | |||
PPBP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of PPBP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPBP | 5473 | 214146_s_at | 0.3935 | 0.2813 | |
| GSE20347 | PPBP | 5473 | 214146_s_at | -0.0332 | 0.6278 | |
| GSE23400 | PPBP | 5473 | 214146_s_at | 0.0917 | 0.0728 | |
| GSE26886 | PPBP | 5473 | 214146_s_at | -0.1516 | 0.4923 | |
| GSE29001 | PPBP | 5473 | 214146_s_at | -0.0909 | 0.6505 | |
| GSE38129 | PPBP | 5473 | 214146_s_at | -0.2104 | 0.5202 | |
| GSE45670 | PPBP | 5473 | 214146_s_at | 2.1695 | 0.0076 | |
| GSE53622 | PPBP | 5473 | 43256 | 0.4667 | 0.0431 | |
| GSE53624 | PPBP | 5473 | 43256 | 0.7325 | 0.0000 | |
| GSE63941 | PPBP | 5473 | 214146_s_at | 0.2412 | 0.7131 | |
| GSE77861 | PPBP | 5473 | 214146_s_at | 0.2944 | 0.2827 | |
| GSE97050 | PPBP | 5473 | A_23_P121596 | -0.3241 | 0.7057 | |
| TCGA | PPBP | 5473 | RNAseq | 1.5957 | 0.0631 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PPBP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPBP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPBP | 5473 | 2 | 9 | 19 | |
| GSE20123 | PPBP | 5473 | 2 | 9 | 19 | |
| GSE43470 | PPBP | 5473 | 0 | 13 | 30 | |
| GSE46452 | PPBP | 5473 | 3 | 34 | 22 | |
| GSE47630 | PPBP | 5473 | 1 | 19 | 20 | |
| GSE54993 | PPBP | 5473 | 7 | 0 | 63 | |
| GSE54994 | PPBP | 5473 | 1 | 9 | 43 | |
| GSE60625 | PPBP | 5473 | 0 | 0 | 11 | |
| GSE74703 | PPBP | 5473 | 0 | 11 | 25 | |
| GSE74704 | PPBP | 5473 | 2 | 5 | 13 | |
| TCGA | PPBP | 5473 | 19 | 28 | 49 |
Total number of gains: 37; Total number of losses: 137; Total Number of normals: 314.
Somatic mutations of PPBP:
Generating mutation plots.
Highly correlated genes for PPBP:
Showing top 20/31 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPBP | DEFB124 | 0.688348 | 3 | 0 | 3 |
| PPBP | ADAT1 | 0.684339 | 3 | 0 | 3 |
| PPBP | ICAM1 | 0.669613 | 3 | 0 | 3 |
| PPBP | C18orf54 | 0.647485 | 3 | 0 | 3 |
| PPBP | SHCBP1 | 0.642185 | 3 | 0 | 3 |
| PPBP | GABRG2 | 0.595499 | 4 | 0 | 3 |
| PPBP | APLNR | 0.587943 | 3 | 0 | 3 |
| PPBP | IL36RN | 0.586976 | 3 | 0 | 3 |
| PPBP | XPO6 | 0.583459 | 3 | 0 | 3 |
| PPBP | CXCL3 | 0.58323 | 6 | 0 | 4 |
| PPBP | BFAR | 0.581046 | 3 | 0 | 3 |
| PPBP | TWISTNB | 0.580396 | 3 | 0 | 3 |
| PPBP | CXCL6 | 0.576341 | 4 | 0 | 3 |
| PPBP | CXCL10 | 0.573328 | 4 | 0 | 3 |
| PPBP | ARC | 0.563442 | 5 | 0 | 4 |
| PPBP | FABP7 | 0.561961 | 3 | 0 | 3 |
| PPBP | LRRC32 | 0.551477 | 3 | 0 | 3 |
| PPBP | PF4V1 | 0.547506 | 5 | 0 | 4 |
| PPBP | BCAM | 0.533893 | 3 | 0 | 3 |
| PPBP | DCTPP1 | 0.533377 | 3 | 0 | 3 |
For details and further investigation, click here
