| Full name: phosphopantothenoylcysteine decarboxylase | Alias Symbol: MDS018|FLJ14585 | ||
| Type: protein-coding gene | Cytoband: 15q24.2 | ||
| Entrez ID: 60490 | HGNC ID: HGNC:28107 | Ensembl Gene: ENSG00000138621 | OMIM ID: 609854 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PPCDC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPCDC | 60490 | 219066_at | -0.6773 | 0.1968 | |
| GSE20347 | PPCDC | 60490 | 219066_at | -0.7113 | 0.0000 | |
| GSE23400 | PPCDC | 60490 | 219066_at | -0.3409 | 0.0000 | |
| GSE26886 | PPCDC | 60490 | 219066_at | -0.8325 | 0.0011 | |
| GSE29001 | PPCDC | 60490 | 219066_at | -0.2640 | 0.4633 | |
| GSE38129 | PPCDC | 60490 | 219066_at | -0.3649 | 0.0186 | |
| GSE45670 | PPCDC | 60490 | 219066_at | 0.0526 | 0.8622 | |
| GSE53622 | PPCDC | 60490 | 68754 | 0.1079 | 0.3343 | |
| GSE53624 | PPCDC | 60490 | 68754 | -0.0112 | 0.9026 | |
| GSE63941 | PPCDC | 60490 | 219066_at | 0.1232 | 0.8606 | |
| GSE77861 | PPCDC | 60490 | 219066_at | -0.4445 | 0.0582 | |
| SRP007169 | PPCDC | 60490 | RNAseq | -0.8773 | 0.0864 | |
| SRP064894 | PPCDC | 60490 | RNAseq | -0.1914 | 0.5394 | |
| SRP133303 | PPCDC | 60490 | RNAseq | -0.3695 | 0.0228 | |
| SRP159526 | PPCDC | 60490 | RNAseq | -0.7640 | 0.0057 | |
| SRP193095 | PPCDC | 60490 | RNAseq | -0.3538 | 0.0025 | |
| SRP219564 | PPCDC | 60490 | RNAseq | -0.3907 | 0.2873 | |
| TCGA | PPCDC | 60490 | RNAseq | -0.0508 | 0.5375 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPCDC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPCDC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPCDC | 60490 | 8 | 1 | 21 | |
| GSE20123 | PPCDC | 60490 | 8 | 1 | 21 | |
| GSE43470 | PPCDC | 60490 | 4 | 6 | 33 | |
| GSE46452 | PPCDC | 60490 | 3 | 7 | 49 | |
| GSE47630 | PPCDC | 60490 | 8 | 10 | 22 | |
| GSE54993 | PPCDC | 60490 | 5 | 6 | 59 | |
| GSE54994 | PPCDC | 60490 | 5 | 7 | 41 | |
| GSE60625 | PPCDC | 60490 | 4 | 0 | 7 | |
| GSE74703 | PPCDC | 60490 | 4 | 3 | 29 | |
| GSE74704 | PPCDC | 60490 | 4 | 1 | 15 | |
| TCGA | PPCDC | 60490 | 14 | 15 | 67 |
Total number of gains: 67; Total number of losses: 57; Total Number of normals: 364.
Somatic mutations of PPCDC:
Generating mutation plots.
Highly correlated genes for PPCDC:
Showing top 20/796 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPCDC | SLC7A4 | 0.72101 | 3 | 0 | 3 |
| PPCDC | USP54 | 0.708684 | 4 | 0 | 4 |
| PPCDC | TPRG1 | 0.708585 | 4 | 0 | 4 |
| PPCDC | KLB | 0.707645 | 4 | 0 | 4 |
| PPCDC | BACH1 | 0.697026 | 4 | 0 | 4 |
| PPCDC | AGFG2 | 0.693564 | 7 | 0 | 7 |
| PPCDC | SCYL2 | 0.691454 | 3 | 0 | 3 |
| PPCDC | B3GALT4 | 0.691064 | 5 | 0 | 4 |
| PPCDC | LRRC29 | 0.690753 | 3 | 0 | 3 |
| PPCDC | SHROOM3 | 0.686881 | 4 | 0 | 4 |
| PPCDC | CBR3-AS1 | 0.68358 | 3 | 0 | 3 |
| PPCDC | MFSD5 | 0.681422 | 6 | 0 | 6 |
| PPCDC | FAM3D | 0.675071 | 4 | 0 | 4 |
| PPCDC | LDHD | 0.674801 | 3 | 0 | 3 |
| PPCDC | TMEM50A | 0.6743 | 3 | 0 | 3 |
| PPCDC | ZNF823 | 0.671335 | 4 | 0 | 3 |
| PPCDC | KCNAB1 | 0.665764 | 3 | 0 | 3 |
| PPCDC | SH3GLB1 | 0.663141 | 7 | 0 | 7 |
| PPCDC | ANKRD13A | 0.663131 | 4 | 0 | 3 |
| PPCDC | CHMP2A | 0.661466 | 7 | 0 | 7 |
For details and further investigation, click here
