| Full name: EF-hand domain family member D2 | Alias Symbol: MGC4342 | ||
| Type: protein-coding gene | Cytoband: 1p36.21 | ||
| Entrez ID: 79180 | HGNC ID: HGNC:28670 | Ensembl Gene: ENSG00000142634 | OMIM ID: 616450 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EFHD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EFHD2 | 79180 | 217992_s_at | 1.1640 | 0.0476 | |
| GSE20347 | EFHD2 | 79180 | 217992_s_at | 0.9296 | 0.0000 | |
| GSE23400 | EFHD2 | 79180 | 217992_s_at | 0.7418 | 0.0000 | |
| GSE26886 | EFHD2 | 79180 | 217992_s_at | 0.6573 | 0.0550 | |
| GSE29001 | EFHD2 | 79180 | 217992_s_at | 0.7776 | 0.0171 | |
| GSE38129 | EFHD2 | 79180 | 217992_s_at | 0.9156 | 0.0000 | |
| GSE45670 | EFHD2 | 79180 | 222483_at | 0.9468 | 0.0001 | |
| GSE53622 | EFHD2 | 79180 | 56543 | 0.7523 | 0.0000 | |
| GSE53624 | EFHD2 | 79180 | 56543 | 0.9159 | 0.0000 | |
| GSE63941 | EFHD2 | 79180 | 217992_s_at | 0.6350 | 0.2859 | |
| GSE77861 | EFHD2 | 79180 | 217992_s_at | 0.6756 | 0.2751 | |
| GSE97050 | EFHD2 | 79180 | A_23_P23443 | 1.2847 | 0.0700 | |
| SRP007169 | EFHD2 | 79180 | RNAseq | -0.3697 | 0.4600 | |
| SRP008496 | EFHD2 | 79180 | RNAseq | -0.3777 | 0.2170 | |
| SRP064894 | EFHD2 | 79180 | RNAseq | 0.8718 | 0.0004 | |
| SRP133303 | EFHD2 | 79180 | RNAseq | 0.8518 | 0.0001 | |
| SRP159526 | EFHD2 | 79180 | RNAseq | -0.0327 | 0.9292 | |
| SRP193095 | EFHD2 | 79180 | RNAseq | 0.4158 | 0.0832 | |
| SRP219564 | EFHD2 | 79180 | RNAseq | 0.5158 | 0.1830 | |
| TCGA | EFHD2 | 79180 | RNAseq | 0.0552 | 0.3675 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by EFHD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EFHD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EFHD2 | 79180 | 0 | 5 | 25 | |
| GSE20123 | EFHD2 | 79180 | 0 | 4 | 26 | |
| GSE43470 | EFHD2 | 79180 | 1 | 8 | 34 | |
| GSE46452 | EFHD2 | 79180 | 7 | 1 | 51 | |
| GSE47630 | EFHD2 | 79180 | 8 | 3 | 29 | |
| GSE54993 | EFHD2 | 79180 | 3 | 1 | 66 | |
| GSE54994 | EFHD2 | 79180 | 10 | 4 | 39 | |
| GSE60625 | EFHD2 | 79180 | 0 | 0 | 11 | |
| GSE74703 | EFHD2 | 79180 | 1 | 5 | 30 | |
| GSE74704 | EFHD2 | 79180 | 0 | 0 | 20 | |
| TCGA | EFHD2 | 79180 | 11 | 23 | 62 |
Total number of gains: 41; Total number of losses: 54; Total Number of normals: 393.
Somatic mutations of EFHD2:
Generating mutation plots.
Highly correlated genes for EFHD2:
Showing top 20/1409 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EFHD2 | RNF4 | 0.758245 | 3 | 0 | 3 |
| EFHD2 | PPP1CA | 0.7526 | 3 | 0 | 3 |
| EFHD2 | IFT52 | 0.728872 | 3 | 0 | 3 |
| EFHD2 | FMNL3 | 0.728554 | 4 | 0 | 4 |
| EFHD2 | INTS10 | 0.723686 | 4 | 0 | 3 |
| EFHD2 | NEIL2 | 0.709677 | 4 | 0 | 4 |
| EFHD2 | FOXC2 | 0.708377 | 3 | 0 | 3 |
| EFHD2 | TNPO1 | 0.708157 | 3 | 0 | 3 |
| EFHD2 | MAD2L2 | 0.707738 | 6 | 0 | 5 |
| EFHD2 | C1QC | 0.701933 | 3 | 0 | 3 |
| EFHD2 | ENTPD4 | 0.700457 | 3 | 0 | 3 |
| EFHD2 | LRRC8C | 0.700301 | 3 | 0 | 3 |
| EFHD2 | TBC1D2 | 0.694776 | 3 | 0 | 3 |
| EFHD2 | SMNDC1 | 0.692259 | 3 | 0 | 3 |
| EFHD2 | RALGAPA2 | 0.690627 | 3 | 0 | 3 |
| EFHD2 | GLIS3 | 0.687868 | 5 | 0 | 5 |
| EFHD2 | KIAA1324L | 0.686294 | 4 | 0 | 3 |
| EFHD2 | MTHFD1L | 0.682826 | 3 | 0 | 3 |
| EFHD2 | SIX4 | 0.682716 | 6 | 0 | 5 |
| EFHD2 | RPRD1B | 0.681592 | 4 | 0 | 3 |
For details and further investigation, click here
